ABSTRACT
Helichrysum caespititium is a valuable and well-known medicinal plant in south and central Africa. The current studyexamined ethnomedicinal uses, chemical and biological properties of H. caespititium. Information on medicinal uses,phytochemistry, and biological activities of H. caespititium were assembled from several internet sources whichincluded Scopus, Google Scholar, Elsevier, Science Direct, Web of Science, Pubmed, SciFinder, and BMC. Additionalinformation was sourced from journal articles, scientific reports, theses, books, and book chapters gathered from theUniversity library. The current study showed that H. caespititium is used for treating several medical conditions,particularly respiratory infections, sexually transmitted infections, nausea, headache, wounds, ulceration, and usedas an aphrodisiac. The pharmacological research showed that H. caespititium extracts and compounds isolated fromthe species have antibacterial, antigonorrhea, antimycobacterial, antifungal, antioxidant, and cytotoxicity activities.This research showed that H. caespititium is an integral part of indigenous pharmacopeia in southern Africa, but thereis lack of alignment between the ethnomedicinal uses and existing biological screening. Therefore, future researchshould focus on evaluation of the chemical and pharmacological properties of H. caespititium extracts and compoundsisolated from the species.