ABSTRACT
Objective Hemapoietic stem cell (HSC) is a kind of pluripotent cell which can differentiate into different kinds of cells,including blood cells and immune cells.Hemapoietic stem cell transplantation(HSCT) is to destory abnormal bone marrow hematopoietic cells,and imbed healthy stem cells to reconstruct hematopoiesis and immune system,and it is an effective therapy for the treatment of hematopoietic malignances,genetic and metabolic disease,autoimmune disease and solid tumor.At present,it has been widely used to treat the patients with hematologial malignant tumors,such as lymphoma and leukemia.Clinical investigation showed that patients with leukemia and psoriasis after HSCT,both leukemia and psoriasis were cured.In this review,the immunopathogenesis of psoriasis,the possible mechanism of psoriasis associated with leukemia,the immunopathogenesis of HSCT and the theory basis of treating psoriasis and the application of HSCT in the treatment of psoriasis with leukemia were comprehensively discussed.
ABSTRACT
Objective To compare the efficiencies of Fenwal CS-3000 plus and Cobe Spectra blood cell separators in collecting peripheral blood stem cells. Methods Thirty-eight stem cell apheresis procedures were performed on 31 patients using Fenwal CS-3000 plus cell separator and 65 procedures performed on 45 patients using Cobe Spectra cell separator. The white blood cell counts and the percentages of mononuclear cells and CD 34 positive cells in the apheresis products of the two groups were compared. Results The WBC counts of the two groups had no significant difference. The mononuclear cell percentage was significantly higher with Fenwal CS-3000 plus than with Cobe Spectra. The mononuclear cell percentage declined with increasing WBC count when using Cobe Spectra. There was no significant difference between CD 34 positive cell percentages of the two groups. There were no significant correlations between the WBC count and the percent of CD 34 cells, between the percent of mononuclear and the percent of CD 34 cells of the apheresis products. Conclusion There is no difference between the collection efficiencies of the two blood cell separators in the collection of peripheral blood stem cells.