Research progress of heparanase in malignant tumor / 国际外科学杂志

Heparanase, an endo- β- D- glucuronidase, that cleaves heparan sulfate chains in heparan sulfate proteoglycans, has recently been found in mammalian. It may play a key role in tumor progression and metastasis. Here we disscuss its molecular structure, biochemical properties, expression in malignant tumor,mechanism in accelerating tumor metastasis and application in heparanase inhibitor.