ABSTRACT
Background: Hepatic complex can be vulnerable to numerous diseases ascribed to the intake of few drugs, alcohol, or infectionswhich manifests itself in oral cavity.Materials and Methods: The patients diagnosed as acute or chronic liver disease by clinical examination, liver function tests,and morphological examination which was selected. Detailed dental and oral examination was done and manifestations suchas the presence of gingival bleeding, oral lichen planus, xerostomia, sialadenitis, stomatitis, periodontal disease, and otherswere noted. The data were then subjected to statistical analysis.Results: Jaundice due to viral hepatitis (44.7%), alcoholic liver diseases (28%), alcoholic cirrhosis (18.7%), cirrhosis of liver(16%), hepatomegaly (14.7%), hepatic carcinoma (7.3%), and hepatitis B (6%) were the various liver disorders encountered.On oral examination, a significantly higher number of study subjects were detected with one or more oral abnormalities whencompared to subjects (P ≤ 0.05). Oral manifestations include periodontitis, halitosis, xerostomia, bald tongue, fissured tongue,hyperpigmentation, candidiasis, and oral lichen planus.Conclusion: The complex mechanism of liver and its susceptibility to a variety of dysfunction can not only have systemic butalso many oral manifestations.
ABSTRACT
The results of this study revealed that there was less discoid cell and more pseudopodium, more thrombocytes tended to agglutinate with increased proportion of hyper - glycogenic platelets. There were also platelets sticking to RBC. WBC and lymphocytes. The glanules within the platelates were decreased or even fused together, unable to differentiate them. The vascular system were dilated and proliferated. Abnormal granules were seen with its size similar to a - granules, covered with membrane, with cytoplasm and metabolites inside. Under the revulsion of ADP, there was 70. 28% agglutining body. Most intercellular spaces revealed unclear bridge - form connection or even disappeared with fusion of cellular membrane. All these changes were more distinctive than that in the control group, demonstrating the changes in ultrasturcture and agglutination function might be one of the causes of blood stasis in hepatopathy.
ABSTRACT
Serum gamma-glutamyl transpeptidase (gamma-glutamyl transferase EC 2.3.2.2) and alkaline phosphatase (EC 3.1.3.1) activities from 115 adults with various hepatic diseases were compared to 200 normal adults. Although the values of both enzymes are significantly above normal in the same liver disorders, the first enzyme is much more sensitive in liver cirrhosis. The two enzymes are correlated very well (r = 0.648, p < 0.0005) in hepatic patients.