ABSTRACT
Rasayogas in Ayurveda have a wide range of therapeutic utility since they are fast acting even in smaller doses. Acharya Charaka mentioned, Jwara is the foremost of all diseases, so it need a special attention. There are various herbal and herbomineral preparation mentioned for Jwara chikitsa mentioned in Brihat trayees, Laghu trayees. Wide variety of Rasa yogas were mentioned in classics for Jwara and Jwarankusa rasa is one among them. Herbomineral preparations mentioned for Jwara have specific mode of action including Ama pachana, Agni vardana, Sroto sodhana and Jwara hara properties. Jwarankusa rasa is a well known herbo mineral formulation specially indicated for Vishama jwara and it is mentioned on Bhaishajya Ratnavali Jwara chikitsa. There are various references available for Jwarankusa rasa with various ingredients and different method of preparation such as Rasendra sara sangraha, Rasa Prakasha sudharakara, Sharangadhara Samhita, Vrinda nigantu ratnakara, Rasa chandamsu. In certain references Jwarankusa rasa consists of only non-herbal ingredients and in other references we can find it as herbomineral combination. Majority of the Yogas contains ingredients such as Parada, Gandhaka, Tankana, Haritala, Manasila among the non-herbal ingredients and Vatsanabha, Sunti, Danti beeja, Dattura beeja among the herbal ingredients. It is mainly indicated in diseases such as Jwara, Jwaratisara, Vishama jwara, Vishoochika. Rasa dravyas are Rasayana yogavahi and possess Amadosha nirharana property. Preparation and observations during preparation of Jwarankusa rasa mentioned in Bhaishajya Ratnavali Jwara chikitsa is emphasized in this humble work.
ABSTRACT
Ayurveda-The traditional medicinal science in India has holistic approach and practiced widely in the subcontinent. Large parts of the Ayurvedic drugs are heromineral preparations. These preparations are broad spectrum as far as its indications are concerned. Definite mode of action of these drugs are inexplicable. Vyadhividhwansana Rasa is an herbomineral preparation used for treating acute fever, interrupted fever, fever of unknown origin, ascites, splenomegaly, colic pain, Vata vyadhi, Aama jwara (first stage of fever) and Vishama jwara (irregular fever). In view of its therapeutic indications an antimicrobial study was designed to ascertain its probable mode of action. The present study aims to evaluate the antimicrobial activity of Vyadhividhwansana Rasa against test organisms at different concentration. Vyadhividhwansana Rasa was prepared as per Ayurvedic texts. Positive control Streptomycin [5mg(w/v)] and negative control 20% dimethyl sulfoxide (DMSO) were prepared. Solution of Vyadhividhwansana Rasa were prepared in three concentrations at 50 mg/ml, 100 mg/ml and 150 mg/ml in DMSO and was tested for its antimicrobial activity against Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi by agar-well diffusion method. The measured Inhibition Zone ranged from 4-34 mm for all the sensitive bacteria. All the bacteria except Salmonella typhi were found Susceptible (S) against Vyadhividhwansana Rasa compared to standard. Salmonella typhi was found Intermediate sensitive (I). The antimicrobial activity of the extracts increased when the solution is more concentrated.