ABSTRACT
Ayurvedic texts are mentioned this Vedic sastra as a science of life. Ayurveda mainly targeted lifestyle of human being as well as mentioned number of drugs on various disorders. Among these disorders, diabetes is a major disorder. Due to which people are suffering lot. Diabetes is a major metabolic as well as lifestyle related disease. Anti-diabetic drugs from modern science can treat this disorder but at the cost of heavy side effects. Diabetic patients are using the modern drugs at higher doses plus these drugs are much costlier. Need of today’s era is to use alternate therapies for diabetes. Among all alternative therapies Ayurveda gives ray of hope by using the Anti-diabetic drugs as mentioned in ancient texts. Ayurveda uses many drugs for diabetes especially herbal and herbomineral preparations. The review paper focuses on various Ayurvedic drugs herbal, herbomineral either in single or compound preparations studied at several research organizations. The paper focuses on antidiabetic properties of Ayurvedic drugs mentioned in Ayurvedic texts as well as their pharmacological, phytochemical properties and their scientific studies.
ABSTRACT
Background: Reverse pharmacology for drug development has been highly productive and cost-effective in recent past as it is based on the documented therapeutic effects of plants in ancient texts. Afrodet Plus® is formulated for the treatment of male infertility, which contains ancient herbo-minerals. Its effi cacy and safety are validated through this animal study in reverse pharmacology mode. Objectives: This study was undertaken to evaluate effi cacy and safety of an Ayurvedic formulation Afrodet Plus® in adult male rats. Materials and Methods: Twelve male rats (Holtzman) between 8 and 10 weeks of age were randomly selected and animals were assigned to a control and two treatment groups. Dosing was performed daily. Various parameters such as weekly body weight, hematology, serum testosterone levels, epididymal sperm count, and effi ciency of Daily Sperm Production (DSP) were evaluated. Results: It was found that epididymal sperm count had signifi cantly increased in both low-dose (+27.39%) and high-dose (+40.5%) groups as compared to control group. The DSP also showed an increase of 43.7% at high dose of 180 mg/kg body weight as compared to the control group. An increase in sperm motility and especially progressive motility was observed when evaluated by Computer Assisted Semen Analyzer. Histological evaluation of testicular tissue for spermatogenic index revealed that the index had increased in treatment group as compared to control group. Conclusion: This study revealed that oral administration of Afrodet Plus® resulted in signifi cant increase in DSP in the testis along with increase in epididymal sperm count and progressive motility as compared to control group without producing any treatment-related adverse effects. These fi ndings provide the documentary evidence that the use of Afrodet Plus® at 90 and 180 mg/kg body weight is effective and safe for the treatment of male infertility especially to improve sperm count and progressive motility.