ABSTRACT
The hereditary multiple osteochondromatosis is a hereditary disorder characterized by gradual development of numerous osteocartilagenous masses from the metaphyseal region of long bones. The abnormality is transmitted as an autosomal dominant trait and its etiology is unknown but many theories of pathogenesis have been advanced. Four members of a family with hereditary multiple osteochondromatosis who are much shorter in height are presented with a brief review of literatures.
Subject(s)
Humans , Exostoses, Multiple HereditaryABSTRACT
Multiple osteochondromatosis is a hereditary disorder affecting the endochondral skeleton during period of growth. We have studied a family which have multiple osteochondromatosis clinically and radiologically. In this family, eight of ten members could traceable, have the lesions of multiple osteochondromatosis. The most common site of the lesions was in femur, and the next common site was in tibia, especially, near the knee joint.