ABSTRACT
Background: Heterotopic gastric mucosa of upper esophagus (HGMUE) earned attention gradually in recent years, and the incidences of esophageal stenosis, esophageal net, dysplasia and adenocarcinoma of upper esophagus caused by HGMUE increased gradually. Aims: To summarize the clinicopathological features of HGMUE patients and analyze its possible risk factors. Methods: A total of 150 HGMUE patients from September 2018 to October 2019 at the People's Hospital of Xinjiang Autonomous Region were collected, and 150 non-HGMUE patients were served as controls. Univariate analysis and multivariate analysis were used to analyze the risk factors of HGMUE. Results: Univariate analysis showed that the incidences of alcohol consumption (P=0.029), Barrett's esophagus (P=0.003) and reflux esophagitis (P=0.001) were significantly increased in HGMUE group than in control group. Unconditional multivariate Logistic regression analysis showed that alcohol consumption, Barrett's esophagus and reflux esophagitis were the independent risk factors of HGMUE (P<0.05). Conclusions: Alcohol consumption, Barrett's esophagus and reflux esophagitis can increase the risk of HGMUE.