ABSTRACT
Background: Ischemic Stroke is a common cause of morbidity and mortality. Various parameters, both clinical and laboratory have been studied as markers of Early Neurological Deterioration (END) out of which CRP has been the most important. This retrospective study of ours is an attempt to study its influence on END by minimizing other variables as much as possible.Methods: 50 patients were chosen retrospectively strictly according to laid down inclusion and exclusion criteria, their data recorded and analyzed with 17.0 SPSS software. Any p value <0.05 was taken as significant.Results: Significantly raised CRP values were found in elderly patients (p=0.0001) and in males (p=0.003). Higher incidences of ENDs were also found in elderly patients (p=0.326) and males (p=0.846) and patients with raised CRP levels (p=0.057).Conclusions: Higher Values of CRP are associated with increased frequency of ENDs. But in patients with multiple factors which can influence both CRP and END, CRP alone should not be thought of as the only culprit.
ABSTRACT
Background: C-reactive protein (CRP) is a systemic inflammatory marker used extensively. QTc interval representsboth ventricular depolarization and repolarization. Hypertension is one of the foremost leading causes ofmorbidity and mortality globally.Objectives: To explore the relationship of systolic blood pressure with QTc interval and CRP levels. Likewise toinvestigate the association of diastolic blood pressure with QTc interval and CRP levels.Materials and Methods: The study was carried out on 100 randomly selected subjects in the age group of 20-45years. Both genders were included. Hypertensive subjects on treatment were also included. Three records ofblood pressure in the supine position were obtained with 2 minute interval between each and average wasconsidered. QT interval and RR interval were measured from standard 12 lead electrocardiogram (ECG). Tangentmethod was used for QT interval and later it was corrected for heart rate to arrive at QTc interval using Bazett’sformula. CRP levels were obtained using high sensitivity (hs-CRP) assay kits.Results: There was a positive and significant association for systolic blood pressure with both QTc and CRP.Likewise we also found a positive and significant association for diastolic blood pressure with both QTc andCRP.Discussion: The inflammatory modulatory processes are altered in hypertension, thereby increasing CRP levels.CRP increases endothelin-1 and reduces nitric oxide leading to vasoconstriction and hypertension. Further CRPcauses autonomic imbalances by increasing sympathetic activity that lead to hypertension and indirectlyprolonging QTc interval. QTc interval is also lengthened by left ventricular hypertrophy as a complication ofhypertension.Conclusion: Hypertension with left ventricular hypertrophy can cause cardiac arrhythmias and sudden cardiacdeath. This may be prevented by early detection of high risk hypertensive subjects or even those prone todevelop hypertension using QTc and CRP indicators. Further these markers are cheap and widely used and theyprovide valuable diagnostic and prognostic features especially in developing countries like India.
ABSTRACT
Safety and effectiveness of powered food made from <i>Agaricus blazei Murill</i> was evaluated by a randomized human study. 45 healthy subjects were divided into 3 groups in sequence: control, 1 pack and 3 packs/day-administered groups. Each group had 15 persons. They had each packs for 28 days, and followed, in every two weeks, by the evaluation with CTCAE v3.0, QOL (SF36-v2), and biochemical examinations including liver/lung/kidney function, insulin resistance and NK activity and high-sensitivity CRP. None of them had adverse events nor biochemical/lung abnormal examinations. 1 and 3 packs-administered groups improved their QOL, high-sensitivity CRP and NK activity in a dose-dependent manner. These results ascertained safety, and effectiveness of the powdered food made from <i>Agaricus blazei Murill</i> against presymptomatic disorders including metabolic syndrome.
ABSTRACT
Objective To investigate the significance of changes of serum high-sensitivity C-reactive protein (hs-CRP),tumor necrosis factor-alpha (TNF-α),interleukin 6 (IL-6) and urinary microalbumine levels in patients with diabetic kidney disease.Methods Serum hs-CRP,TNF-α,IL-6 and urinary microalbumine levels were measured with RIA in 60 type 2 diabetic patients and 20 controls.The 60 diabetic patients were divided into three groups based on urine albumin excretion rate.Group A:without alblminuria ( UAER ＜ 20 μg/ min,n =20 ) ; Group B:micro-albuminuria ( UAER ＜ 200 μg/min,n =20 ) ; Group C:macro-albuminuria ( UAER ＞ 200 μg/min,n =20 ).The serum levels of hs-CRP,TNF-α,IL-6 of patients in the four groups were measured.Results The serum levels of hs-CRP,TNF-α,IL-6 of patients in the healthy group were ( 1.21 ± 0.87 ) mg/L,( 1.27 ± 0.93 ) ng/L and ( 4.31 ± 1.72 ) ng/L,in the nonalbuminuria group were ( 2.31 ± 1.07 ) mg/L,( 1.95 ± 1.34 ) ng/L and ( 5.79 ± 1.68 ) ng/L,in the microalbuminuria group were ( 3.47 ± 1.25 ) mg/L,(2.86 ± 1.26) ng/L,(7.13 ± 1.57 ) ng/L,in the macroalbuminuria group were (4.83 ± 1.47 ) mg/L,(4.03 ±1.43)ng/L,(9.14 ±2.43)ng/L Serum levels of hs-CRP,TNF-α and IL-6 were significantly higher in all the patients with type 2 diabetes than those in the control group (P ＜ 0.01 ).Serum levels of hs-CRP,TNF-α and IL-6 were significantly higher in type 2 diabetic patients with microalbuminuria than those in patients without albuminuria (P ＜0.05).Serum levels of hs-CRP,TNF-α and IL-6 were significantly higher in diabetic patients with macroalbuminuria than those in patients with micrealbuminuria (P ＜ 0.01 ).The levels of hs-CRP,TNF-αand IL-6 were positively related to the urinary microalbumine levels ( rs =0.67,0.64,0.75,P ＜ 0.01 ).Conclusion Determination of serum hs-CRP,TNF-α and IL-6 levels might be helpful for early detection of diabetic kidney disease and monitoring the progress of the disease process.