ABSTRACT
Objective:To observe the clinical efficacy and side effects of highly agglutinative staphylococcin injection at high dose combined with oxaliplatin or cisplatin with intraperitoneal perfusion in the treatment of malignant peritoneal effusion. Methods:Totally 60 patients with malignant peritoneal effusion were divided into two groups,32 cases in group A,and 28 cases in group B. Group A was treated with staphylococcin at high dose combined with oxaliplatin with intraperitoneal infusion after peritoneal cavity catheter drainage,and group B was treated with staphylococcin at high dose combined with cisplatin with intraperitoneal infusion after peritoneal cavity catheter drainage. All patients underwent the treatment once a week,and continuous four weeks for a courese. The clinical efficacy and adverse drug reactions were compared between the two groups. Results:The complete response rate of group A was 18. 8% ,and the total effective rate was 90. 7% ,which were both significantly higher than those of group B(P 0. 05). Conclusion:Staphylococcin at high dose combined with oxaliplatin with intraperitoneal perfusion is more effective than staphylococcin at high dose combined with cisplatin. Although abdominal pain in group A is obvious,the patients are able to tolerate with it after the symptomatic treatment,therefore,staphylococcin at high dose combined with oxaliplatin with intraperitoneal perfusion can be used as one of effective methods for the treatment of malignant peritoneal effusion.
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Objective To summarize the nursing experience of combination therapy of highly agglutinative staphylococcin (HASL) with cisplatin for patients with malignant pleural effusions. Methods After fully draining of pleural fluid in 62 cases with malignant pleural effusion through pleural puncture through central venous catheters and simply suction bottles, we injected HASL and cisplatin into the patients' pleural cavities. During the therapeutic process, firstly, we drained the pleural fluid fully before injection, secondly, we directed the patients to cooperate well and alter the positions properly, and thirdly, we closely observed the patients' condition and adverse reactions. Results 54 of 62 cases were effective after the therapies. The effective rate was 87.1%.Conclusions In order to achieve a satisfled curative effect and reduce the adverse reactions, we need the cooperation of the patients, fully draining of the pleural fluid before injection and proper alternation of the patients' positions during the treatment process.
ABSTRACT
OBJECTIVE: To observe the clinical efficacy of highly agglutinative staphylococcin (HAS) combined with cisplatin in the treatment of malignant hydrothorax after straining and inserting central venous catheter in thoracic cavity. METHODS: 90 patients with malignant hydrothorax combined with lung cancer were randomly divided into A、B、C 3 groups. Central venous catheter was inserted in thoracic cavity for strainage. Group A were intrapleural injected with 5 000 U HAS, group B 40 mg?m-2 cisplatin and group C 5 000 U HAS combined with 40 mg?m-2 cisplatin once a week. Clinical efficacies of 3 groups were evaluated after 3 weeks of treatment. RESULTS: The total effective rate of group A, B and C were 43.0%, 46.7% and 80.0% respectively. There was obvious difference between group C and A as well as group B(P