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Objective:To explore the clinicaland pathological characteristics of aortitisin order to improve the understanding of this rare conditionand improve correct diagnostic rate.Methods:Twenty-four cases of active aortitis were identified from a total of 1 838 cases of ascending aorta specimens in the last 6 years at Wuhan Asia General Hospital. Clinical data including medical history, laboratory and imaging data were collected and the treatment with immunosuppressive and hormonal treatment as well as follow-up data were analyzed. Pathological data including gross findings, microscopic features of the aortic valve and aorta were analyzed. Continuous variables were expressed as mean±standard deviation. Frequencies were described as percentages. Results:Among the 24 cases of active aortitis, 1 case was clinically diagnosed as aortitis before operation, 7 cases were suspected aortitis before operation, and the other 16 cases were diagnosed as aortitis after pathological examination. Among those 16 cases, one case was Behcet′s syndrome, 2 cases were infectious aortitis, 3 cases were Takayasu aortitis, and 10 cases were clinically isolated aortitis. None case had aortic stenosis, while 21 cases had aortic valve insufficiency. Eleven cases of aortitis showed coagulation necrosis. In the 5 cases of Behcet′s syndrome, 3 had acute noninfectious endocarditis of aortic valve.Conclusions:Most of the aortitis in this study was found accidentally in pathological examination. All of the clinically isolated aortitiswere misdiagnosed before pathological examination. Most of the patients with aortitis had simple aortic valve insufficiency. Coagulation necrosis is an important clue for the diagnosis of aortitis. Acute noninfectious endocarditis is an important clue for the diagnosis of Behcet′s syndrome.
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Objective To investigate the value of lung adenocarcinoma classification developed by International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society ( IASLC/ATS/ERS) in predicting the effect of three-dimensional radiotherapy ( 3DRT) after surgery for locally advanced lung adenocarcinoma.Methods The clinical data of 150 patients with invasive lung adenocarcinoma who underwent radical resection and systematic lymph node dissection in Tianjin Medical University from 2010 to 2013 were analyzed, and according to the IASLC/ATS/ERS classification, they were divided into lepidic predominant group (LEP group), acinar predominant group (ACN group), papillary predominant group (PAP group), micropapillary predominant group (MIP group), and solid predominant group (SOL group), and further divided into LEP group, CAN/PAP group, and MIP/SOL group.The overall survival ( OS) and disease-free survival ( DFS) rates were compared between groups.The Kaplan-Meier method was used to calculate survival rates, the log-rank test was used for survival difference analysis and univariate prognostic analysis, and the Cox proportional hazards model was used for multivariate prognostic analysis.Results Among all the patients, the median OS and DFS rates were 30.8 and 25.8 months, respectively.For the patients in the LEP group, ACN/PAP group, and MIP/SOL group, the median OS rates were 40.0, 32.2, and 28.4 months, respectively ( P=0.005) , and the median DFS rates were 29.2, 25.8, and 24.2 months, respectively ( P=0.011) .For the ACN/PAP group, the patients who received or did not receive radiotherapy had a median OS rate of 37.4 or 25.3 months ( P=0.000) and a DFS rate of 31.1 or 25.2 months (P=0.000).For the MIP/SOL group, the patients who received or did not receive radiotherapy had a median OS rate of 28.3 or 27.4 months ( P=0.783) and a DFS rate of 25.3 or 24.0 months ( P=0.732 ) .Conclusions The IASLC/ATS/ERS classification helps to predict the prognosis of patients with locally advanced invasive lung adenocarcinoma who receive postoperative radiotherapy.Postoperative radiotherapy can be performed for ACN and PAP patients, while there is no need to perform radiotherapy for MIP and SOL patients .
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Los meningiomas son neoplasias primarias frecuentes del sitema nervioso central, usualmente benignas y susceptibles de curación mediante cirugía. Se presentan los hallazgos clínicos y morfológicos en una casuística de 580 meningiomas diagnosticados durante el período 1980 a 2003. Estos tumores representaron el 16 por ciento de las neoplasias del sistema nervioso central y la gran mayoría fueron únicos (85 por ciento de los casos), con localización intracraneana preferente y manifestaciones clínicas relacionadas con el tamaño y localización del tumor. Afectaron con mayor frecuencia a mujeres (relación 2.4:1) y a pacientes con edades comprendidas entre los 30 a 59 años (67 por ciento de los casos). Según la clasificación histológicas de la Organización Mundial de la Salud, 80 por ciento de los meningiomas correspondieron al grado histológico I (beningnos), 17 por ciento al grado II (atípicos) y apenas 3 por ciento al grado (malignos). El subtipo histológico más frecuente fue la variante transicional. Resulta importante para el patólogo reconocer y clasificar adecuadamente a los meningiomas, puesto que de ello depende el tratamiento y pronóstico de este tipo frecuente de neoplasia
Meningiomas are frequent primary neoplasms of the central nervous system, usually benign and susceptible to healing through surgery. The clinical and morphological discoveries are presented in a study of 580 meningiomas diagnosed during the period 1980-2003. These tumors represented a 16% of the neoplasms of the central nervous system and most of them were unique (85% of the cases), with preferential intracranial localization and clinical manifestations related to the size and localization of the tumor. Women were affected more frequently (the rate female/male of 2.4:1) and patients with ages among 30 and 59 years (67% of the cases). According to the histologic classification of the World Health Organization, 80% of the meningiomas corresponded to histological grade I (benign), 17% to grade II (atypical) andonly 3% to grade III (malignant). The most frequent histological subtype was the transitional variant. It is important for the pathologist to recognize and classify adequately the meningiomas, since upon this depends the treatment and prognosis of this frequent kind of neoplasm
Subject(s)
Humans , Male , Adult , Female , Middle Aged , Eosine Yellowish-(YS)/analysis , Hematoxylin/analysis , Meningeal Neoplasms/surgery , Meningeal Neoplasms/pathology , Central Nervous System Neoplasms/surgery , Central Nervous System Neoplasms/pathology , Paraffin/analysis , Recurrence/prevention & control , Biopsy/methods , Meningioma/classificationABSTRACT
PURPOSE: The prognostic factors for carcinoma of the Ampulla of Vater have not been fully identified. This study was undertaken in order to determine whether or not immunohistochemical staining can be used identify the potential diagnostic and prognostic markers for carcinoma of the Ampulla of Vater. METHODS: We studied twenty four patients with carcinoma of the Ampulla of Vater who underwent curative resection from September 1995 to February 2003 at the Department of Surgery, Dong-A University Medical Center. All the specimens were reviewed by an expert pathologist, and immunohistochemical stains were used to differentiate the pathologic type. RESULTS: The overall 5-year survival rate was 58.3%, and survival was closely correlated with the pathologic differentiation. For the immunohistochemical stains, CK20 and MUC2 were significantly effective to differentiate the intestinal type and the pancreaticobiliary type of carcinoma for the Ampulla of Vater (P=0.0162 and P=0.0001, respectively). CONCLUSION: Further investigations with a larger number of cases would enable us to use immunohistochemical stains to improve the differentiation of carcinoma of the Ampulla of Vater.
Subject(s)
Humans , Academic Medical Centers , Ampulla of Vater , Classification , Coloring Agents , Survival RateABSTRACT
BACKGROUND: In general, chronic myelogenous leukemia (CML) are classified according to the criteria established by the International Bone Marrow Transplant Registry. However, when a marrow aspirate cannot be obtained because of myelofibrosis or other causes, bone marrow biopsy specimens can be used to provide diagnostic information. As compared with the marrow aspirate, the assessment of the blasts is a major difficulty with biopsy specimen. Anti-CD34 is a monoclonal antibody that reacts with leukemic blasts and bone marrow progenitor cells, immunohistochemical staining for CD34 can be used to classify three phases of CML when the aspirates of bone marrow is inadequate. METHODS: The authors studied 38 bone marrow biopsy specimens, it were diagnosed as CML, representing three phases of disease (chronic, accelerated, and blastic crisis). Immunohistochemical staining for CD34 was performed using CD34 monoclonal antibody in paraffin- embedded tissue. We assess a correlation between the clinical phases of CML and the proportion of CD34 positive cells. RESULTS: The proportion of CD34 positive cells among chronic, accelerated, blastic phases, and indeterminate group of CML were 4.3 (1.7~9.0)%, 10.1 (7.4~12.7)%, 31.2 (10.2~87.3)%, and 13.35 (8.7~20.0)%, respectively. The differences in CD34 positivity between various phases of CML were highly significant (P=0.0001). We classified CML according to bone marrow histology; granulocytic types and granulocytic/megakaryocytic (mixed) type. The differences in CD34 positivity among histologic types were significant high proportion of CD34 positive cells (P=0.0191) in granulocytic type of blastic phase. CONCLUSION: This study demonstrated that CD34 immunohistochemical staining represents a reliable method for classifying CML in cases in where a bone marrow aspirate is not available, and further studies are needed in order to find out the relationship between a degree of CD34 positivity and histologic classification.