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Introducción: El Cáncer de tiroides es la neoplasia maligna más frecuente del sistema endócrino. Durante las últimas décadas se ha observado un aumento de su incidencia de forma progresiva en numerosos países y regiones del mundo. Objetivos: Determinar la prevalencia de Cáncer de tiroides y, los tipos histológicos, en 3 hospitales de referencia en Paraguay. Materiales y métodos: Estudio observacional, descriptivo, retrospectivo, de corte transversal. Se incluyó a todos los pacientes sometidos a tiroidectomía parcial o total en el Hospital de Clínicas, Instituto de Previsión Social e Instituto Nacional del Cáncer, entre los años 2011 y 2015. Resultados: La prevalencia de cáncer de tiroides fue de 23,7% de 1913 pacientes sometidos a tiroidectomía. El 85,7% fueron del sexo femenino. La edad media fue de 43±14 años. El 85,4 % de los pacientes presentó Carcinoma Papilar; el 9,5% Carcinoma Folicular; el 3,1% Carcinoma Medular; el 1,6% Carcinoma Anaplásico y el 0,4% Carcinoma Papilar + Carcinoma Folicular en el mismo paciente. El sexo femenino fue más frecuente en todos los tipos histológicos y, el Carcinoma Medular resultó igual en ambos sexos. La edad media de los pacientes con Carcinoma Papilar fue de 42±13 años, Carcinoma Medular 49±15 años, del Carcinoma Folicular 50±18 años y Carcinoma Anaplásico 69±11 años. El tamaño promedio del Carcinoma Papilar fue de 19±17 mm, del Carcinoma Folicular 53±24 mm, del Carcinoma Medular 40±22 mm, y el Carcinoma Anaplásico 50±35 mm. Conclusión: Aproximadamente 1 de cada 4 pacientes sometidos a tiroidectomía presentó cáncer de tiroides, siendo más frecuente en el sexo femenino y, el Carcinoma Papilar es el tipo histológico más frecuente.
Introduction: Thyroid cancer is the most frequent malignant neoplasm of the endocrine system. During the last decades, an increase in its incidence has been observed progressively in many countries and regions of the world. Objectives: To determine the prevalence of thyroid cancer and its histological types in thyroidectomies carried out in reference hospitals in Paraguay. Materials and methods: Observational, descriptive, retrospective, cross-sectional study. All patients undergoing partial or total thyroidectomy at the Hospital de Clínicas, Instituto de Previsión Social and Instituto Nacional del Cáncer between 2011 and 2015 were included. Results: The prevalence of thyroid cancer was 23.7% of 1913 patients undergoing thyroidectomy. 85.7% were female. The mean age was 43 ± 14 years. 85.4% of the patients presented Papillary Carcinoma; 9.5% Follicular Carcinoma; 3.1% Medullary Carcinoma; 1.6% Anaplastic Carcinoma and 0.4% Papillary Carcinoma + Follicular Carcinoma in the same patient. The mean age of the patients with Papillary Carcinoma was 42 ± 13 years, Medullary Carcinoma 49 ± 15 years, Follicular Carcinoma 50 ± 18 years, and Anaplastic Carcinoma 69 ± 11 years. The average size of Papillary Carcinoma was 19 ± 17 mm, Medullary Carcinoma 40 ± 22 mm, Anaplastic Carcinoma 50 ± 35 mm, and Follicular Carcinoma 53 ± 24 mm. Conclusion: About 1 in 4 patients undergoing thyroidectomy has thyroid cancer, it is more frequent in women, and the most frequent histological type is Papillary Carcinoma.
Subject(s)
Thyroid Neoplasms , Thyroid Neoplasms/pathology , Paraguay , PrevalenceABSTRACT
Background: Malignant epithelial tumours are the most common ovarian cancers and also the most lethal gynaecological malignancies. This study was undertaken to analyse histomorphological spectrum and clinicopathological correlation of ovarian tumours. Methods: This retrospective study was done for the period of one year at Department of Pathology, New Civil Hospital, Surat, which is a tertiary health care center. Here we studied 55 cases of ovarian mass received in formalin, which were subjected to histopathological examination and immunohistochemistry as and when required. Results: In total, 55 ovarian tumour specimens were examined. Out of which 28 cases (51%) were benign, 3 cases (5%) were borderline and 24 cases (44%) were malignant. Most common histological type was surface epithelial tumours (60%) followed by germ cell tumours (13%). The commonest benign tumour was mucinous cystadenoma and commonest malignant tumour was serous adenocarcinoma. Malignancy was quite common in ovarian masses in our institute. Conclusions: Ovarian tumours are quite common in our set up and epithelial tumours are the commonest variety of ovarian tumours. The histological type of ovarian tumour correlates with the prognosis of the tumour.
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Objective To investigate the correlation of extent and pattern of computed tomography ( CT) enhancement of tumor lesions and histological types in advanced gastric carcinoma .Methods A total of 121 ca-ses of advanced gastric carcinoma were included in this study .Tri-phase enchanced 64-slice spiral CT scan-ning was performed before operation for every patient .We judged the extent lesions′of and pattern of enhance-ment using axial images combined with reconstruction of VR ,MPR and MIP.Then the radiographic result of every subject was compared with its corresponding postoperative histological type after operation .Results In the pres-ent study,the correlation of extent of CT enhancement of tumor lesions and histological types were as follows :ade-nocarcinoma patients were mostly with moderate enhancement ( n=57,61.3%),mucinous adenocarcinoma pa-tients were mostly with mild enhancement (n=7,46.7%).While obvious enhancement were mostly observed in patients with signet ring cell carcinoma(n=8,61.5%).The correlation of pattern of CT enhancement of tumor lesions and histological types were as follows:adenocarcinoma patients were mostly with well -distributed en-hancement(n=58,62.4%),while endothecium obvious enhancement were mostly seen in patients with mucinous adenocarcinoma(n=13,86.7%)and signet ring cell carcinoma (n=7,58.3%).Conclusions There are signif-icant correlation between advanced gastric carcinoma′s tri-phases enhancement characteristics with 64-slice spiral CT and its histological types .Judging histological type using 64-slice spiral CT before operation is useful for formulating and optimizing the therapeutic regimen for gastric cancer patients ,and it is significant for observing the tumors′biological behavior and judging the curative effect .
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Introducción: El carcinoma basocelular (CBC) corresponde a la neoplasia maligna más común en la población humana. Sus tasas de incidencia están aumentando en todo el mundo. Objetivo: El propósito de esta investigación fue analizar la localización anatómica del CBC facial y cuero cabelludo, por sexo y agresividad histológica. Metodología: Se analizaron 1732 casos de CBC (958 mujeres, 774 hombres), provenientes de 4 hospitales públicos de Santiago, Chile, durante los años 2005-2009. Las localizaciones analizadas fueron: cuero cabelludo, la frente, los párpados, la zona del ojo, las orejas, la mejilla izquierda, mejilla derecha, región medio facial y el mentón. Los subtipos histológicos Micronodular, Morfeiforme y Metatípico fueron clasificados como histológicamente agresivos, mientras que los tipos histológicos Sólido, Queratótico, Quístico, Adenoideo y Superficial se clasificaron como histológicamente no agresivos. El análisis estadístico se realizó mediante la prueba de Chi cuadrado. Resultados: Se observó una mayor frecuencia de CBC en la región medio facial (42,8 por ciento) seguida de la frente (11,3 por ciento), el párpado (10 por ciento), las orejas (7,5 por ciento), el cuero cabelludo (4,21 por ciento) y el mentón (1,85 por ciento). Discusión: Estos resultados están de acuerdo en su gran mayoría con los obtenidos en publicaciones internacionales. La distribución del CBC en cara está relacionada directamente con el grado de exposición a la radiación ultravioleta de cada sitio anatómico. En cuanto al género, la frecuencia de CBC fue mayor en mujeres que en hombres en todos los lugares anatómicos en el rostro. En el cuero cabelludo, los hombres mostraron una mayor proporción de CBC. En cuanto a la agresividad de los tumores, no hubo diferencias significativas en los lugares observados. Además, los histológicamente no agresivos fueron mayores en frecuencia en todas las localizaciones dentro de la cabeza...
Introduction: Basal cell carcinoma (BCC) of the skin is now the most common malignancy in the human population. Its incidence rates are increasing worldwide. Objective: The purpose of this research was to analyze the anatomical location of facial and scalp BCC, per gender and histological aggressiveness. Methodology: A total of 1732 (958 females, 774 males), BCC from 4 state hospitals from Santiago, Chile (2005-2009) was studied. The analyzed subsides were: scalp, forehead, eyelid, eye zone, ears, left cheek, right cheek, middle face and chin. Micronodular, Morpheiform and Metatipical histological subtypes were classified as aggressive and Superficial, Keratotic, Adenoid, Nodular were classified as non-aggressive histological subtypes. The statistical analysis was performed by the Chi square test. Results: We observed a highest frequency of BCC in middle face (42.8 percent) followed by forehead (11.3 percent), eyelid (10 percent), ears (7.5 percent), scalp (4.21 percent) and chin (1.85 percent). Discussion: These results are mainly in agreement with those obtained in other populations reported in the international literature; the BCC distribution in the head is related to ultraviolet radiation exposure of each anatomical site. Regarding the gender, the frequency of BCC was higher in females than in males in all anatomical locations within the face. In the scalp, males showed a higher proportion of BCC. Regarding the aggressitivity of the tumours, no differences within the locations were observed. Also, non-aggressive histological tumors were higher in frequency in all locations within the head. This investigation helps to identify the possible risk zones of BCC within the face and scalp in the Chilean population.
Subject(s)
Humans , Male , Adolescent , Adult , Female , Young Adult , Middle Aged , Aged, 80 and over , Carcinoma, Basal Cell/epidemiology , Carcinoma, Basal Cell/pathology , Head and Neck Neoplasms/epidemiology , Head and Neck Neoplasms/pathology , Chile , Hospitals, Public/statistics & numerical data , Neoplasm Invasiveness , Facial Neoplasms/epidemiology , Facial Neoplasms/pathology , Sex DistributionABSTRACT
In carcinoma ex pleomorphic adenoma (CXPA), pleomorphic adenoma (PA) and diverse carcinoma components showing luminal (ductal) or non-luminal (myoepithelial) differentiation coexist. To elucidate the clinicopathological implications of cellular differentiation in CXPA and the potential role of p53, vascular endothelial growth factor (VEGF), c-erbB-2, c-kit, and glucose transporter 1 (Glut-1) in carcinogenesis, we analyzed 11 CXPAs with luminal differentiation (CXPAs-LD) and 6 CXPAs with non-luminal differentiation (CXPAs-NLD) and compared protein expressions in residual PAs and carcinomas by immunohistochemistry. Among the CXPAs-LD, 5 were invasive and 8 were histologically high-grade tumors. The 5-year survival rate was 72.7%. P53, c-erbB-2, VEGF, and Glut-1 were more immunoreactive in carcinoma components than in PAs (P = 0.008, 0.004, 0.002, and 0.024, respectively); c-erbB-2 overexpression was associated with high histological grade (P = 0.024). Carcinoma components frequently lacked c-kit expression (P = 0.009). CXPAs-NLD were all low-grade and invasive with a larger mean tumor size (5.2 cm) than CXPAs-LD (3.3 cm) (P = 0.040). The patients remained disease-free without significant immunohistochemical expression. The immunoprofiles and clinical course of CXPA differed according to cellular differentiation. Therefore, it is important to report the histological subtype and to assess potential biomarkers in diagnostic and therapeutic trials.