ABSTRACT
Objective@#To improve the diagnostic quality of hepatolenticular degeneration by summarizing the clinicopathological features.@*Methods@#A retrospective analysis of 21 cases that were diagnosed as hepatolenticular degeneration with liver biopsy in our hospital from January 2013 to August 2018 was reviewed, and then their clinicopathologic features were analyzed. The pathomorphological differences between liver biopsy and liver biopsy after transplantation, and the relationship between histopathological patterns and biopsy types and clinical indicators were analyzed by Fisher's exact test.@*Results@#Of the 21 patients with hepatolenticular degeneration, 10 patients had liver biopsy, and 11 patients underwent liver biopsy after liver transplantation. Among them, four cases were presented as simple fatty liver pattern (19.0%, 4/21), eight cases as steatohepatitis pattern (38.1%, 8/21), four cases as inflammatory necrosis without cirrhosis pattern (19.0%, 4/21), and five cases as inflammatory necrosis with cirrhosis pattern (23.9%, 5/21). Twelve cases had copper deposition in the liver (57.1%, 12/21), and the pattern of copper distribution in the liver was uneven.@*Conclusion@#A clinicalpathological features of hepatolenticular degeneration mainly manifests in four patterns, but lack characteristic changes. Hence, comprehensive judgment should rely on clinical history, laboratory examination, genetic test results and liver histopathological changes.
ABSTRACT
Odontogenic tumours encompass a diverse group of uncommon tumours that are frequently aggressive in their biological behaviour. They comprise 2.4% of all the lesions biopsied in the dental office. Odontogenic tumours have for years been recognized for presenting clinical & histopathological challenges arising from epithelial, ectomesenchymal and/or mesenchymal elements of tooth forming tissues. Understanding of the most common and rare odontogenic tumours will be of great use in their study and clinical management. Histological patterns and sub-patterns are characteristic of particular tumours, hence serve as a proverbial beacon to arrive at a confirmatory histopathological diagnosis. The molecular mechanisms of Epithelial Mesenchymal Interaction have long been studied as a basis for these versatile tumour patterns. Morphogenesis and cell differentiation in the developing tooth are controlled by a series of reciprocal interactions between the epithelial and mesenchymal tissues. In these rare neoplasms, there is lack of information about ectomesenchymal interactions which is involved in the pathogenesis of these tumours. Our paper aims to assess the validity of tumour pattern as a unique prognostic parameter for odontogenic tumours.
ABSTRACT
BACKGROUND: Clinical features of malignant melanoma (MM) are known to be different according to racial and environmental factors. Recently, there have been reports of an increase of MM. OBJECTIVE: We evaluated the incidence of tumors, age and sex distribution, tumor sites, and histopathological patterns. METHODS: Clinical records were reviewed for 35 cases of MM with a histologically confirmed diagnosis for patients who visited the Department of Dermatology, Chungnam National University Hospital during the 20 years from 1980 to 1999. Histopathologic and clinical characteristics were also reviewed. RESULTS: A total of 35 malignant melanoma cases diagnosed at Chungnam National University Hospital during the past 20 years from 1980 to 1999 were included for the clinico-histopathologic study. The ratio of man to woman with MM was 1 : 1.33 with a mean age of 55 years. Acral lentigenous melanoma was the most common clinico-histopathologic pattern. CONCLUSION: The incidence of MM has increased during the past 20 years. The common site, and histopathologic patterns show a significant difference from Caucasians.