ABSTRACT
Objective: To explore the correlation of quantitative features of shear wave elastography (SWE) of breast cancer with its molecular subtypes and histopathological features. Methods: The 107 lesions of 106 cases of breast cancer confirmed by pathology were examined by conventional ultrasonography and SWE before surgery. The maximum elasticity values (E Max) and elasticity ratio (E ratio) were recorded. We also recorded the immunohistochemical features including clinical pathological features and molecular subtypes (Luminal A, Luminal B, Erb-B2 overexpression and Basal-like), and analyzed its correlation with E Max and E ratio. Results: There were significant differences in mass size, pathological grade, BI-RADS classification, E Max and E ratio between the 4 subtypes (P<0.05). As for hardness among the 4 subtypes, the largest one was Erb-B2 overexpression, followed by Luminal-like and the smallest was Basal-like, with statistically significant differences among the subgroups (P<0.05). The stiffness of various pathological types of breast cancer was disparate, among which mucous carcinoma was the hardest, followed by ductal carcinoma and medullary carcinoma, and lobular carcinoma was the softest. The E Max and E ratio increased with the increase of mass size with linear correlation. The higher the pathological grade and BI-RADS classification of the lesion, the greater value of E Max and E ratio, with significant differences (P<0.05). Conclusion: There is a certain degree of correlation between the stiffness of breast cancer and its molecular subtypes and histopathological features. The evaluation of lesions by SWE can provide important reference for endocrine therapy and prognosis evaluation of breast cancer.
ABSTRACT
Objective To investigate the pathological features and prognostic analysis in endoscopic strip-ping microflap excision of vocal cords leukoplakia.Methods A total of 186 cases with vocal cord leukoplakia and treated by endoscopic stripping microflap excision were retrospectively analyzed,calculated the ratios of recurrence and malignant transformation on keratosis without dysplasia,mild dysplasia,moderate dysplasia and severe dysplasia and carcinoma in situ.Then,the association of histopathological classification with recurrence and malignant transformation in vocal cord leukoplakia were evaluated.Results 87 cases of all 186 patients with vocal cord leukoplakia were kera-tosis without dysplasia,17 cases were recurrenced and 3 cases were developed to carcinoma;64 cases were mild dysplasia,15 cases were recurrenced and 7 cases were developed to carcinoma;29 cases were moderate dysplasia, 13 cases were recurrenced and 10 cases were developed to carcinoma;6 cases were severe dysplasia and carcinoma in situ,all 6 cases were recurrenced and 5 cases were developed to carcinoma.Conclusion The histopathological classi-fication is predictive factor for the risk of recurrence and malignant transformation in vocal cord leukoplakia.