The common histopathological findings of colon biopsies in Northern Saudi Arabia

Background: Colorectal cancer is considered as the most prevalent cancer among men and the third mostfrequent cancer among women in Saudi Arabia. Consequently, we aimed to assess the commonhistopathological findings of colon biopsies in Northern Saudi Arabia. Methodology: This study hasinvestigated the histopathological diagnosis of 88 patients subjected for colon and small intestine biopsies, theirages ranging from 18 to 99 years with a mean age of 48 years old at the Department of Pathology at KingKhalid Hospital, Hail, Northern Saudi Arabia. Results: Out of the 88 patients, 53(60.2%) were males and35(39.8%) were females. Diagnoses were reached in 77/88(87.5%) of the patients and could not be ascertainedin 11/88(12.5%). Adenocarcinoma was diagnosed in 10/77(13%) of the patients (9/10(90%) in colon-site and1/9(10%) in the small intestine. Conclusion: Colorectal precancerous and cancerous lesions are relativelyprevalent among patients referred to colorectal diagnostic biopsy. There is a substantial percentage ofinflammatory bowel cases among those referred to colorectal biopsies in Saudi Arabia.

Comments to “A Case of Lipoatrophia Semicircularis Confirmed by Ultrasonography” / 대한피부과학회지

No abstract available.

A Clinical and Histopathological Study of 17 Cases of Cutaneous Pseudolymphoma / 대한피부과학회지

BACKGROUND: Although it is important to be aware of the clinicopathological features of pseudolymphoma of the skin to avoid misdiagnosis, there are few comprehensive studies on this disease entity in the Korean dermatologic literature. OBJECTIVE: The purpose of this study was to evaluate the clinical and histopathological features of pseudolymphoma. METHODS: We reviewed the medical records, photographs and histopathological slides of 17 patients, who had been diagnosed with cutaneous pseudolymphoma, between March 2001 and August 2011. RESULTS: The ratio of males to females was 1:3.3, and the mean age of onset was 47.8 years old. Ten patients (59%) had no symptom and the most commonly involved site was the head and neck (59%). Ten patients (59%) had a solitary lesion. Nobody had a family history or past history of pseudolymphoma or lymphoma. Of the 17 cases, 16 (94%) were idiopathic. The common microscopic feature of pseudolymphoma was diffuse and dense lymphocytic infiltration in the reticular dermis. In the immunohistochemical staining of 15 cases (88%), the infiltrating cells were positive for both B cell and T cell marker. The treatment included intralesional steroid injection, systemic steroids and excision. An average follow-up period was 38.4 months (from 2 to 107 months) for 13 patients. During this period, no recurrence or malignant transformation was observed in these patients. CONCLUSION: Our findings demonstrate that cutaneous pseudolymphoma is most common in middle-aged female, and it has a good response to steroid treatment or simple excision, without malignant transformation.

Changes of Histopathological Findings with Time in the Dermographism Lesion / 대한피부과학회지

Changes of histopathological findings with time were studied after scratching the skin of 37 patients with dermographism. Biopsies were also done in 13 normal healthy controls for comparison with unstroked skin of the patients. 1. Biopsies of unscratched skin of the patients showed no histologic difference from those of the skin from controls. 2. Neutrophils increased in number with time after scratching and maximum neutrophil count (mean 16.08+/-24.17/HPF) was observed at 90 minutes after scratching 3. Eosinophilic infiltration was also similar to that of neutrophils. Maximum eosinophil count (mean 324+/-4.76/HPF) was found at 60 minutes after scratching. 4. L ymphohistiocytic infiltration showed a similar tendency to that of neutrophils, but the degree of change was not so prorninent. 5. Before scratching, mast cell count in patients with dermographism showed no difference in number when compared with norrnal controls. In patients with dermographism, mast; cell count inclined to decrease after scratching. 6. Edema and lymphatic dilatation in the upper dermis were most prominent at 5 minutes after scratching and disappeared slowly thereafter.

Clinical and Histopathological Observation of Porokeratosis / 대한피부과학회지

We observed clinical and histopathological findings of porokeratosis in 16 cases which comprised 2 linear types, 4 superficial disseminat:ed forms, 4 disseminated superficial actinic porokeratosis and 6 plaque types. From the observation, the following results were obtained. l. Clinical results 1) Eleven cases were men, 5 cases were women, and the sex ratio was 2. 2 to 1, age distribution was from 6 to 61 years (mean age: 34. 2years), and the distribution of age of onsets was from 2 to 52 years(mean age of onset' 23. lyears). 2) Four cases had family history of porokeratosis, but linear forms did not. 3) Nine cases had pruritus especially, all cases of DSAP and DSP except 1 case complained pruritus. 4) Tmo cases of DSAP had tendency of summer exacerbations. 2. Histopathological results 1) Cornoid lamellae were prominent in all cases of plaque types and linear types, and minimal in all cases of DSAP and DSP except 1 case. 2) Epidermis between the cornoid lamellae were normal or acanthotic in all cases except 1 case of plaque types and linear types, and were atrophic in 5 cases of 8 cases in DSAP and DSP.