Acroqueratosis Verruciforme de Hopf: A propósito de un caso / Hopf Verruciform Acrokeratosis: A purpose of a case

RESUMEN La acroqueratosis verruciforme de Hopf (AV) es una enfermedad genética de transmisión autosómica dominante, una entidad poco frecuente, caracterizada, desde el punto de vista epidemiológico, por presentaruna distribución mundial, yafectara todas las razas, puede iniciarse en la infancia o de forma tardía en la edad adulta, con predominio del sexo masculino, caracterizada por pápulas queratósicas, aisladas, localizadas en dorso de manos, pies, brazos, codos y rodillas. El diagnostico se confirma con la histopatología existiendo en la actualidad varias alternativas terapéuticas. Se reporta el caso de un paciente, de sexo masculino, de 24 años de edad, quienpresenta una dermatosis de 8 años de evolución, caracterizada por lesiones papulosas queratósicasasimétricas, asintomáticas, localizadas en miembro superior derecho.

ABSTRACT Hopfverruciformacroqueratosis (VA) is a dominant autosomal transmitted genetic disease. It is an infrequent entity, characterized, from the epidemiological point of view, for presenting a worldwide distribution affecting all races, it begins in childhood or late in adulthood, with a predominance of males, caracterized by keratotic papules, isloted, located on the back, on the hands, feet, arms, elbows and knees. The diagnosis is confirmed with histopathology and there are currently several therapeutic alternatives. The case of a 24 year-old male that present a dermatological condition of 8 years of evolution, it is characterized by asimmetricalqueratotic papules lesions, located on the right upper limb, asymptomatics.

Non-familial Acrokeratosis Verruciformis of Hopf

Acrokeratosis verruciformis of Hopf is a rare genodermatosis with an autosomal dominant mode of inheritance. It is a disorder of keratinization, characterized by multiple, flat-topped, skin-colored keratotic lesions resembling plane warts typically observed on the dorsum of the hands and feet. Histopathologically, the lesion shows considerable hyperkeratosis, acanthosis, and papillomatosis, mimicking a "church spire", and a thickened granular layer. It arises in early life, often at birth or infancy. Herein, we report on a rare sporadic case of acrokeratosis verruciformis of Hopf. A 44-year-old Caucasian man presented with multiple, grouped, hyperkeratotic, whitish, flat papules on his shins and feet, which had been present for more than one year. Histopathological examination showed typical findings of acrokeratosis verruciformis of Hopf. Our case is unique in that the patient had no familial history of similar skin lesions.

Tasa de crecimiento poblacional del rotífero Brachionus rotundiformis (Rotifera: Brachionidae) en un quimiostato de dos cámaras

Population growth rate of the rotifer Brachionus rotundiformis (Rotifera: Brachionidae) in two-stage chemostat. The population growth rates of Brachionus rotundiformis were estimated in two-stage chemostat cultures. Chlorella sorokiniana was supplied continuously from a steady state culture growing with constant illumination on limiting nitrate. Rotifer growth in the second stage was limited by the rate of algal supply. The algal supply rate and rotifer population growth rate were determined by the second-stage dilution rate. The maximum population growth rate in the transient state of B. rotundiformis (1.96 day-1) was observed at 2.5 x 106 cel/ml of the algae whereas in the steady state the maximum population growth rate (1.09 day-1) was similar to the point Hopf’s bifurcation predicted by Fussmann and was observed at 1 x 106 cel/ml of the algae. In the transient state, the rotifer’s growth rate increased and the duplication time decreased at higher algal concentrations, until reaching a peak where the population growth rate begins to decrease. In the steady state, the opposite was true. The growth rates observed in this work are among the highest recorded for this rotifer in continuous cultures. Rev. Biol. Trop. 56 (3): 1149-1157. Epub 2008 September 30.

Se estimaron las tasas de crecimiento poblacionales de Brachionus rotundiformis en un quimiostato de dos cámaras. Suministramos Chlorella sorokiniana continuamente a partir de un cultivo en estado estacionario con iluminación constante y nitrato como nutriente limitante. El crecimiento del rotífero en la segunda cámara estuvo limitado por la tasa de suministro del alga. La tasa de suministro del alga y la tasa de crecimiento poblacional del rotífero fueron determinadas a partir de la tasa de dilución en la segunda cámara. La tasa máxima poblacional de crecimiento en estado de transición de B. rotundiformis (1.96 día-1) se obtuvo a 2.5 x106 cel/ml del alga, mientras que en estado estacionario la tasa máxima (1.09 día-1) fue similar al punto de bifurcación de Hopf predicho en Fussmann et al., (2000) y se obtuvo a 1 x106 cel/ml del alga. En la fase de transición se observó que a mayor concentración del alga, mayor era la tasa de crecimiento del rotífero y menor su tiempo de duplicación, hasta alcanzar un pico donde comienza a decrecer. En la fase estacionaria se observó lo contrario. Los valores obtenidos se encuentran entre los más altos reportados hasta ahora para este rotífero en cultivos continuos.

A Case of Acrokeratosis Verruciformis of Hopf / 대한피부과학회지

Acrokeratosis verruciformis of Hopf is a localized disorder of keratinization affecting the distal extremities. It develops during infancy or early childhood with no sexual predilection. The disease seems to be inherited in an autosomal dominant fashion. We describe a 55-year-old male with multiple, flat-topped papules on the left dorsum of the hand. The histologic findings showed marked hyperkeratosis, acanthosis, papillomatosis of the epidermis and circumscribed elevation of the epidermis which characteristically resembled "church spires". This case is unusual in that the patient had late onset of the lesions and no family history of the condition.