ABSTRACT
Polycystic ovarian syndrome (PCOS) is a physiological disorder that causes many negative effects involving a variety of systems in the body, such as the endocrine, metabolic, psychological, and reproductive systems. An individual may present with a variety of reproductive, metabolic, and psychological problems. Method In this descriptive cross-sectional study, women of reproductive age group (15–35 yrs), presenting with infertility, irregular menstruation, acne, hirsuitism and obesity were included. Consecutive sample method and total 139 patients were included. Detailed history with specific emphasis on history of infertility, age, menstrual history (oligomenorrhoea; regular or irregular menses), and obesity was done. Serum FSH, LH, and LH:FSH ratio levels were estimated. TVS/TA, increase in number of follicles in ovary (multiple follicles), and increase in ovarian volume were noted. Result Out of the 139 patients studied at PRH, maximum patients (88.5%) had normal levels of Sr. LH. These normal levels were of follicular and luteal phase. Remaining 16 (11.5%) had increased levels of Sr. LH. Out of the 139 patients studied at PRH, majority (99.3%) of the patients had normal levels of Sr. FSH. These normal levels were of follicular and luteal phase. Only 1(0.7%) patient had decreased level of Sr. FSH. Of the 139 patients studied at PRH with evidence of PCOS, 58 (41.7%) patients had increased ratio of Sr. LH:Sr. FSH (i.e., ≥2:1). Remaining 81(58.3%) patients had normal ratio. In the present study of 139 patients, 65 patients had exclusive USG findings, 13 (9.4%) patients had exclusive hormonal evidence and 45 patients had combined USG and hormonal evidence. Overall 16 (11.5%) patients had neither of the evidence (although they had clinical features of PCOS). Conclusion Hormonal evidence of PCOS was present. Of these serums, LH levels were raised in majority of the cases and also raised LH:FSH ratio despite the values of hormones being in normal range. Both, i.e., USG alone and USG combined hormonal, were good evaluators for clinically suspected cases of PCOS.
ABSTRACT
Evaluar el efecto de las recomendaciones dietéticas en la regresión de la telarquia prematura en lactantes y preescolares (entre 3 meses y 5 años y 11 meses de edad). Se estudiaron 80 pacientes con diagnóstico de telarquia prematura divididas en: grupo A de 31 pacientes (con dieta exenta de productos avícolas, tubérculos y soya) y grupo B de 41 pacientes (sin dieta). Servicio de Ginecología Infantil y Juvenil. Hospital de Niños "Dr. JM de los Ríos". Caracas. No hubo diferencia estadísticamente significativa en la edad de las pacientes: grupos A y B respectivamente (31,56 ± 22,40 meses vs. 43,44 ± 26,47 meses; P = 0,09). No se obtuvo variación significativa entre los grupos con respecto a la longitud del útero, (25,32 ± 5,09 mm vs. 28,20 ± 6,69 mm; P = 0,09) y al volumen ovárico derecho (0,52 ± 0,33 cm³ vs. 0,79 ± 0,69 cm³, P = 0,09). Se encontró diferencia estadísticamente significativa en el volumen ovárico izquierdo (0,45 ± 0,29 cm³ vs. 0,91 ± 1,40 cm³; P = 0,01). Se encontró aumento en los niveles de FSH para la edad de las pacientes (3,27 ± 2,29 mUI/mL vs. 2,88 ± 1,74 mUI/mL; P = 0,50). Los niveles de LH se encontraron dentro de límites normales (0,50 ± 0,81 mUI/mL vs. 0,51 ± 0,57 mUI/mL; P = 0,05). Las cifras de estradiol resultaron ligeramente elevadas (16,60 ± 12,12 pg/mL vs. 16,44 ± 8,79 pg/mL P = 0,95). El tiempo de regresión fue menor en el grupo B: 16 ± 6,19 meses vs. 10,75 ± 1,75 meses; (P = 0,01). La dieta de restricción de productos avícolas, tubérculos y soya no resultó de utilidad en la regresión de la telarquia prematura en las pacientes incluidas en este estudio
To evaluate the effect of dietary restriction in the regression of premature thelarche in infants (3 months to 2 years old) and preschooler children (2 to 5 years and 11 months old). 80 patients with diagnostic of premature thelarche divided into: group A with 31 patients (with diet exempt of avian products, tubercles and soybean) and group B with 41 patients (without diet). Servicio de Ginecologia Infantil y Juvenil. Hospital de Niños "Dr. JM de los Rios". Caracas. There was no significative statistical difference in age of patients: groups A and B respectively (31.56 ± 22.40 months vs. 43.44 ± 26.47 months; P = 0.09). There was no significative variation between groups in uterus length (25.32 ± 5.09 mm vs. 28.20 ± 6.69 mm; P = 0.09) and right ovarian volume (0.52 ± 0.33 cm³ vs. 0.79 ± 0.69 cm³, P = 0,09). There was a significative statistical difference in left ovarian volume (0.45 ± 0.29 cm³ vs. 0.91 ± 1.40 cm³; P = 0.11). An increase of FSH levels for age of patients was found (3.27 ± 2.29 mUI/mL vs. 2.88 ± 1.74 mUI/mL; P = 0.50). LH levels were within normal limits (0.50 ± 0.81 mUI/mL vs. 0.51 ± 0.57 mUI/mL; P = 0.96). Estradiol values resulted lightly increased (16.60 ± 12.12 pg/mL vs. 16.44 ± 8.79 pg/mL P = 0.95). The regression time was shorter in the group B: 16 ± 6.19 months vs. 10.75 ± 1.75 months; (P = 0.01). The diet with restriction of avian products, tubercles and soybean was no useful in the regression of premature thelarche in the patients included in this study