ABSTRACT
Prosopis cineraria (L.) Druce is a deep rooted, nitrogen fixing, multipurpose tree endemic to the hot deserts of India. Its synonym is Prosopis spicigera. It belongs to the family Leguminosae and subfamily Mimosoideae. In view of its medicinal importance, the present research was focused on the analgesic properties of roots of P. cineraria by in vitro approach in rats. The analgesic activity of root of Prosopis cineraria was studied using hot-plate method and tail-immersion method in rats. Doses of the ethanolic extract of 200mg/kg & 300mg/kg, orally were selected for analgesic activity. The extract at all the doses used and the Diclofenac sodium significantly inhibited both the analgesic activity for hot plate and tail immersion method. The present study demonstrates the potential analgesic effect of ethanolic extracts of Prosopis cineraria roots. The dose of 200mg/kg b.w is very effective than 300mg/kg b.w in both above pharmacological models.