ABSTRACT
GH/IGF-1 axis is involved in the whole process of human's growth,and its trait of activity would change in varied ages that might affect human longevity.Humanin is a novel mitochondriai-associated polypeptide which has wide-spectrum neural and cellular protection.Hormone and its derivatives play a positive role on a variety of age-related diseases,such as stroke,myocardial ischemia reperfusion,atherosclerosis,diabetes,etc.Recently,relevant studies show a negative correlation between the plasma level of Hormone and the activity of GH/IGF-1 axis,while a positive correlation between the plasma level of Hormone and human longevity.Additionally,evidences have demonstrated that Hormone and its derivatives can protect the beta cells as well as improve insulin sensitivity,which is greatly expected to become an effective means of prevention and treatment to diabetes in the future.