Analysis of 1019 cases with rabies exposure and prophylaxis / 中华实验和临床病毒学杂志

Objective@#To understand the prophylaxis of population exposed to rabies, and provide a basis for prevention and control of rabies.@*Methods@#The registration data of 1 019 cases with rabies exposure in Beijing Ditan Hospital Affiliated to Capital Medical University from Mar, 2017 to Feb, 2018 were analyzed using the descriptive epidemiologic method.@*Results@#Among the 1 019 cases of rabies exposure, the sex ratio of men to women was 0.90∶1, with the highest proportion of them were between 26 and 46 years of age old, accounting for 46.5%. Rabies exposure reached its peak (46.9%) between June and September. In addition, 63.3% of the injuries were caused by dogs and 36.7% by cats. Most of the wounds (55.1%) occurred in hands; and the second was lower limbs (26.6%). Most of the cases (60.7%) had grade II wounds; followed by grade III wounds (39.1%); 69.3% of the cases completed immunization with rabies vaccine. In grade III exposure, 73.7% of the patients were immunized with rabies immunoglobulin. Most of the persons of grade III exposure (73.7%) received inoculation with human rabies immunoglobulin (HRIG).@*Conclusions@#Measures to control rabies should be focused on the management of dogs and cats and the standardization of rabies post-exposure prophylaxis.

Analysis of the early immune effects of rabies vaccine combined with human rabies immunoglobulin / 中华实验和临床病毒学杂志

Objective@#To investigate the early immune effects of rabies vaccine combined with human rabies immunoglobulin (HRIG).@*Methods@#Rapid fluorescent focus inhibition test (RFFIT) was used to test the titers of rabies virus neutralizing antibodies (RVNA). The titers of RVNA of persons who had exposed to rabies at degree III on day 0, day 1, day 7, day 14 and day 45 were compared. The dynamic curves and seroconversion rates (SCR) of RVNA in persons of different genders, age and vaccine regimens (Essen and Zagreb) groups were analyzed.@*Results@#No significant differences of SCR among different genders, age and vaccine regimens groups were observed on the same day. SCR could be 100% on day14 in different groups. The dynamic curves of RVNA within the first 14 days showed the models of gradual rise, rapid rise and rapid decline.@*Conclusions@#The dynamic curves of RVNA within the first 14 days varied when rabies vaccines were used in combination with HRIG, and not all subjects were proved to be protected based on the RVNA detection within this period.

Epidemiological analysis on the open- patient cases of rabies admitted to CDC clinic of Fujian province in 2007 / 中国人兽共患病学报

To analyze the epidemiological factors of the open patient cases admitted to the clinic of Fujian CDC in 2007 for the purpose of prevention of rabies. The descriptive research methods in this study was used, including the gender, age, time admitted to out-patient department(OPD), level of exposure, treatment for the bitten wound, timeliness of inoculating rabies vaccine and therapy with human rabies immunoglobulins ,and the species of attacking animal . Data analysis showed that, in 2007, the OPD for dog injury of Fujian CDC had accepted 4128 cases bitten by dogs, among which children under 10 years old and adults of 21-41 years old constituted majority of cases who were bitten and injured by animals. The exposed cases which were sent to hospitals or OPD within 5 hours only 14.22%;while the percentage of cases received human rabies immunoglobulins was only 14.27%. However, the percentage of cases which were bitten and hurt by pet dogs was 64.27%. Those results indicate the need of strengthen people's knowledge and public education on rabies control and prevention, and the dog feeding management, includes cleaning of wound immediately after bitten by animals, especially the immediate use of rabies immunoglubulins and inoculation with rabies vaccine.

An Epidemiological Investigation on Post-exposure Prophylaxis after Biting by Dogs and Other Animals in the Rabies Endemic Area,Cixi City / 中国疫苗和免疫

Objective To better understand the treament effect of postexposure after biting by dogs and other animals in,Cixi city,and to provide evidence for rabies control.Methods The people,who were bitten by dogs and other animals,were investigated.All related information was collected such as the date and site of bite,animal species,postexposure treatment including vaccination and anti-rabies serum or human anti-rabies immune globulin.Results Total 21,504 cases had received the postexposure treatment from January to September in 2007.Among 21,504 people,95% were attributed to dog bites.62% of people had received the treatment within 12 hours after exposure.All people had received five doses of vaccine.Total 783 people had been administered anti-rabies serum.Furthermore,no sever side effect and rabies cases occurred among these people.Conclusions The injury caused by dogs was still a major potential factor to cause rabies in the rabies endemic area.The timely and correct postexposure treatment with good quality of vaccine could prevent from rabies.