ABSTRACT
Objective The objective of this study was to explore the association between human papillomavirus( HPV) and prognosis of lung cancer by meta-analysis. Methods The PubMed,Embase and Cochrane literature databases studies were searched using a combination of subject terms and free words. As of October 2018,a total of 123 related documents were obtained. After screen-ing the literature according to inclusion and exclusion criteria,the basic information of the study,HPV detection methods,lung cancer patients,hazard ratio(HR)values and 95% confidence interval(CI)were extracted from each study. The meta-analysis of random effects models was used to evaluate the correlation between HPV infection and prognosis in patients with lung cancer. Heterogeneity was assessed using the Q test and I2statistics,and publication bias was tested using Egger′s linear regression test and Begg′s rank cor-relation test. Results The study finally included 11 articles(9 in Asia,2 in Europe and US),and 1439 patients with lung cancer. Meta-analysis using a random-effects model showed no significant association between HPV infection and prognosis of lung cancer (HR=0. 90,95% CI:0. 71~1. 13). A stratified analysis of lung cancer pathological subtypes showed that the prognosis of patients with HPV-infected lung adenocarcinoma was significantly better than that in patients without HPV-infected lung adenocarcinoma (HR=0. 65,95% CI:0. 49~0. 85). Sensitivity analysis was performed by sequentially removing the included studies,and the results were not statistically significant. The results of Egger′s test(P=0. 708)and Begg′s test(P=0. 784)suggest that there is no publica-tion bias in this study. Conclusion HPV infection may be related to the prognostic of patients with lung adenocarcinoma. More basic and clinical studies are needed to further explore the association between HPV infection and lung adenocarcinoma as well as the corre-sponding mechanisms in the future.
ABSTRACT
Objective To determine the rate of human papillomavirus virus (HPV)infection and HPV subtypes distribution in women from Yingtan,so as to provide more reliable and scientific clinical data for the prevention and control of cervical carcinoma. Methods 4 165 women were retrospectively analyzed,who were outpatients or physical examination people of Railroad Branch of People′s Hospital of Yingtan from January 2011 to June 2013.23 types of HPV genotypes were detected in cervical samples by u-sing the nucleic acid amplification and reverse dot hybridization technology.Results 1 311 HPV positive samples were found in 4 165 women (31.48%),of which 20.86% with single HPV genotype infection,6.27% with double HPV genotypes infection, 2.76% with triple HPV genotypes infection,0.84% with quadriad HPV genotypes infection,and 0.72% with more than quadriad HPV genotypes infection.HPV52 had the highest infection rate,accounting for 12.43%,following with HPV43,58,16.>20-25 age group had the highest infection rate(43.19%).Conclusion Women have high HPV infection rate in Yingtan,and HPV subtypes such as HPV52,43,58,16 are superior infection genotypes.