ABSTRACT
Objective To investigate the efficacy and safety of ALA-PDT combined with Quxietang douc-hing in the treatment of cervical HPV infection.Methods 208 female cervical PCR-HPV positive patients were randomly divided into treatment group and control group,each group had 104 cases.The control group received 10%(ALA)in cervical for 3 hours,then red light for 30 minutes once a week,a total of 3 times.Treatment group was given 10% (ALA)in cervical for 3 hours,then red light for 30 minutes once a week,a total of 3 times,and douching vagina with Quxietang,one day at a time,stay 3 weeks.After treatment for 3 months,every month,a cervical PCR-HPV check was conducted,summarized virus removal efficiency.Results The virus removal efficiency of treatment group was 89.42%,that of the control group was 73.08%,the difference was statistically significant (χ2 =7.471,P<0.05 ).The patients in the treatment group had light local mild erythema,swelling,burning pain,without treatment subside.Conclusion ALA -PDT combined with Quxietang douching method is efficient,with mild adverse reactions,the treatment group was better than the control group in removing cervical HPV infection and effectively eliminating the hidden trouble of cervical HPV.
ABSTRACT
Objective To study the relationship between the level of HPV (hs -HPV)infection in the cervical lavage fluid and the virus clearance.Methods 89 cases of hs -HPV infection were selected as research subjects.According to the different outcomes of 1 year,the patients were divided into persistent infection group (23 cases)and negative group (66 cases).The cervical lavage fluid immunoglobulin (IgA,IgM,IgG)in the two groups were detected,and 37 normal people were selected as control group.The relationship between cervical lavage protein immunoglobulin (IgA,IgM,IgG)level and the removal of hs-HPV was studied.Results Of 89 cases of different types of hs-HPV infection,16 type and 18 type accounted for 55.1%,20.2%;different type of hs-HPV infected cervical lavage fluid,the immunoglobulin IgA,IgM,IgG by the analysis of variance showed no significant difference (P0.05 )concen-tration had no significant difference,persistent infection group [IgA(17 ±3.1)μg/mL,IgG(86.2 ±5.4)μg/mL,IgM (14.8 ±3.1)μg/mL].The negative group [IgA(18.6 ±3.6)μg/mL,IgG(93.8 ±6.7)μg/mL,IgM(15.8 ± 3.3)μg/mL]were higher than those of the normal control group [IgA(14.6 ±2.6)μg/mL,IgM(81.3 ±8.5)μg/mL, IgG(11.2 ±2.3)μg/mL],the differences were statistically significant (F=6.547,6.928,10.217,all P<0.05). Conclusion The immune defense of the vaginal mucosa is closely related to the high risk of HPV,especially the sIgA plays an important role in the outcome of infection.