Efficacy and Safety of Hydrotalcite Combined with Omeprazole versus Omeprazole for Gastric Ulcer ：A Meta-analysis / 中国药房

OBJECTIVE： To systematically evaluate the efficacy and safety of hydrotalcite combined with omeprazole for gastric ulcer， and to provide evidence-based reference for clinical treatment. METHODS： Retrieved from PubMed， Embase， Medline， the Cochrane library， CNKI， VIP and Wanfang database， randomized controlled trials （RCTs） about hydrotalcite combined with omeprazole （trial group） versus omeprazole alone （control group） for gastric ulcer during the database establishment to Aug. 2018. After data extraction of included literatures met inclusion criteria， and quality evaluation with Cochrane evaluator manual 5.0.1， Meta-analysis was performed for response rate， the incidence of ADR， recurrence rate of gastric ulcer bleeding， needed time of clinical symptom improvement and hospitalization stays by using Rev Man 5.3 statistical software. RESULTS： A total of 16 RCTs， involving 1 802 patients were included. The results of Meta-analysis showed that response rate [RR＝1.24， 95％CI（1.19，1.29）， P＜0.001] of trial group was significantly higher than that of control group； recurrence rate of gastric ulcer [RR＝0.27，95％CI（0.17，0.45），P＜0.001]， clinical symptom improvement time [MD＝－2.04，95％CI（－2.25，       －1.83），P＜0.001] and hospitalization time [MD＝－4.25，95％CI（－4.55，－3.95），P＜0.001] of trial group were significantly lower or shorter than those of control group， with statistical significance. There was no statistical significance in the incidence of ADR [RR＝0.68，95％CI（0.46，1.02），P＝0.06] between 2 groups. CONCLUSIONS： Compared with omeprazole alone， hydrotalcite combined with omeprazole for gastric ulcer can obviously increase the clinical response rate， decrease the recurrence rate of gastric ulcer and shorten the needed time of clinical symptom improvement and hospitalization time， but do not increase the incidence of ADR.

Mechanism underlying the inhibitory effects of Hydrotalcite on Helicobacter pylori / 中华消化杂志

Objective To explore the mechanism underlying the inhibitory effects of Hydrotalcite on Helicobacter pylori (H.pylori).Methods H.pylori international standard strain 26695 was resuscitated and incubated in Columbia solid culture medium and brucella broth.It was divided int6 blank control group,H.pylori injured group and H.pylori with Hydrotalcite group.H.pylori were treated by Hydrotalcite,and the viability changes of H.pylori were observed.The morphological changes of H.pylori were detected by Gram's stain.The changes of mycoproteins expression of H.pylori were examined by Coomassie blue stain.The effects of H.pylori on cell apoptosis of gastric epithelial cell line GES-1 was compared between groups with and without Hydrotalcite.Subcellular structure and attachment ability of H.pylori on GES-1 cells were observed with transmission electron microscopy and scanning electron microscopy.T test was performed for statistical analysis.Results Hydrotalcite could inhibit the growth of H.pylori.However there were no significant morphological changes of H.pylori.Many mycoproteins were regulated by Hydrotalcite.Without Hydrotalcite,a large amount of H.pylori attached on the cell surface of GES-1 promoted the apoptosis of GES-1 cell.Compared with blank control group,the apoptosis rate of GES-1 cells increased after treated by H.pylori ((5.52 ± 1.31)％ vs (28.96 ±3.14)％),and the difference was statistically significant (t=-11.94,P＜0.05).Hydrotalcite could prevent the attachment of H.pylori on cells,which reduced the apoptosis caused by H.pylori ((28.96 ±3.14) ％ vs (19.38 ± 1.91) ％),and the difference was stattstically significant (t =4.52,P ＜ 0.05).Conclusion Hydrotalcite has inhibitory effects on H.pylori in vitro and play a role in regulation of many mycoproteins.Hydrotalcite can reduce the attachment of H.pylori on gastric epithelial cells,and protect cells from H.pylori injury.

Clinical effect of hydrotalcite in treating bile reflux gastritis in 33 cases / 中国生化药物杂志

Objective To evaluate the clinical effect of hydrotalcite in treatment of bile reflux gastritis.Methods66 patients with bile reflux gastritis were chosen in our hospital from May 2013 to May 2014 as the research object, according to the order of admission they were divided into two groups, 33 cases of control group were treated with sucralfate treatment, observation group patients were treated with hydrotalcite comparative analysis, clinical curative effect in the observation group and the control group of patients were compared.ResultsAfter treatment for a period of time after the 33 patients in the control group,the total effective treatment for 28 cases, the total effective rate was 84.85%, the observation group of 33 cases of patients treated with total effective number of 32 cases, the total effective rate was 96.97%.The effective rate of the observation group was significantly higher than that of the control group(P<0.05).After the corresponding treatment, the incidence of complication in the control group was 15.15%, the observation group was 9.09%.There was no significant difference in the incidence of complications between the two groups.ConclusionThe use of hydrotalcite in treatment of bile reflux gastritis clinical curative effect significantly, can improve the treatment efficiency to a certain extent, high safety.

Mucosal healing quality of hydrotalcite combined with esomeprazole in gastric ulcer / 中华消化杂志

Objective To explore the mucosal healing quality of hydrotalcite combined with esomeprazole in gastric ulcer.Methods Forty-two patients visiting from June 2014 to December 2015 and diagnosed with gastric ulcer were selected and divided into combination therapy group and single therapy group with 21 patients in each group.The patients of combination therapy group received esomeprazole combined with hydrotalcite,and the patients of single therapy group received esomeprazole alone.The total therapeutic course was eight weeks.At the same period,21 health check-up participants were enrolled as normal control group.The healing of gastric ulcer was observed under white light endoscopy.The morphological changes of gastric pits and microvessel of mucosal at peripheral mucosa around ulcer and normal gastric mucosal were observed under narrow band imaging magnifying endoscopy.The gastric mucosa tissues of the two groups before and after treatment,and normal gastric mucosa of healthy control group were taken.The amount of deposition and composition of collagen fibers,the expression level of factor Ⅷ,the level of transforming growth factor (TGF)-beta1 and the content of hydroxyproline were analyzed by Masson,immunofluorescent and immunohistochemistry staining as well as enzyme linked immunosorbent assay.Chi square test,one-way analysis of variance (ANOVA),least significant difference (LSD) method,Dunnett's T3 and Kruskal-Wallis test and other method were used for comparison.Results After treatment,18 patients of combination therapy group (21 patients) had regular microvessel nets (85.7％),which was significantly more than those of single therapy group (12 cases,57.1％) and healthy control group (10 cases,47.6 ％),and the differences were statistically significant (x2 =4.200,P=0.040).In the comparison of maturity of regenerative mucosa between combination therapy group and single therapy group after treatment,the ration between collagen type Ⅰ and Ⅱ,deposition of collagen fibers,the number of factor Ⅷ positive cells,the level of TGF-beta1 and the content of hydroxyproline were 36.05 and 23.14;269 375.63.± 171 608.63 and 137 693.14±98 330.93;34.91±8.40 and 28.24±6.93;104 498.71±40 487.96 and 70 757.11±19 323.95;(1 897.80±879.35) and (1 230.57±536.05) μg/L,respectively;while in healthy control group,the above parameters were 36.81,245 696.90 ± 224 687.00,23.10 ± 8.40,94 048.04 ±41 306.55 and 1 681.20 ± 423.61 μg/L,and the differences were statitically significant among these three groups (H=7.375,F=3.465,11.680,5.190,5.160;all P＜0.05).Those parameters of combination therapy group were significantly higher than those of single therapy group (H=2.416,LSD method;all P＜0.05).Conclusion Hydrotalcite combined with esomeprazole in the treatment of gastric ulcer could significantly improve microvessel morphology,maturity degree of regenerative mucosal structure and function,and the mucosal healing quality was also superior to single esomeprazole group.

Determination of Contents, Extraction and Migration of Mg and Al in Polypropylene Infusion Bottles by ICP-MS / 中国药师

Objective:To establish an ICP-MS method to determine the contents, extraction and migration of Mg and Al in poly-propylene infusion bottles. Methods:An ignition pretreatment method was adopted to determine the contents of Mg and Al in the mate-rials. Five different extraction media with extreme extraction were used to extract and test Mg and Al in polypropylene infusion bottles. Three injections commonly used in clinics were put into polypropylene infusion bottles to carry out accelerated experiment, and the con-tents of Mg and Al were determined by ICP-MS. Results:Mg and Al both had a good linear relationship within the range of 0. 025-1. 0μg·ml-1 (r =0.999 8 and 0.999 0). The recoveries for polypropylene infusion bottles and extraction and migration test were 93. 77%-105. 0% and 96. 53%-103. 89% with RSD of 0. 4%-6. 9% and 1. 0%-7. 1%(n=9), respectively. Conclusion:The meth-od is accurate, sensitive and simple, which can provide reference for the safety data of polypropylene infusion bottles.

Psychological intervention combined with hydrotalcite in treatment of gastroesophageal reflux disease clinical research / 中国生化药物杂志

Objective To study the psychological intervention combined with hydrotalcite in treatment of gastroesophageal reflux disease clinical effect.Methods 100 patients with gastroesophageal reflux in our hospital from February 2015 to October 2016 were selected as the research object in this study.They were randomly divided into the control group and the experimental group, each group was divided into two groups.The control group of hydrotalcite in treatment of chewing, oral.The patients in the experimental group received psychological intervention on the basis of hydrotalcite treatment, strengthen the communication with patients, patients understand the inner confusion, eliminate the patient anxiety and discomfort, improve the treatment compliance of patients.Comparative analysis of the experimental group and control group of patients with treatment effect.Results After treatment, 50 patients in the experimental group, the total effective number of cases of clinical symptoms was improved in all cases, the effective rate of treatment was 92%, and the number of effective cases of electronic gastroscope mucosal repair was 47 cases, the effective rate was.In the control group of 50 cases, the total effective number of cases of clinical symptoms was improved in 40 cases, the effective rate of treatment was 80%, and the number of effective cases of electronic gastroscope mucosal repair was 41 cases, the effective rate was about 82%.The effective rate of the experimental group was significantly higher than that of the control group(P<0.05).Conclusion Psychological intervention combined with hydrotalcite in treatment of gastroesophageal reflux disease has good clinical effect, can improve the therapeutic effect in a certain extent, with further clinical promotion and application significance.

Síntesis y caracterización estructural de hidrotalcitas de Cu-Zn-Al / Synthesis and structural characterization of Zn-Al-Cu hydrotalcites / Síntese e caracterização estrutural de hidrotalcitas de Cu-Zn-Al

Las hidrotalcitas pueden ser usadas en áreas como catálisis, medicina, química ambiental, entre otras. Dependiendo de los metales presentes, los sólidos derivados de la calcinación de hidrotalcitas también son usados debido a su carácter básico, efecto de memoria y alta área superficial especifica. En este estudio se describen algunas características de hidrotalcitas a base de Cu-Zn-Al. Los análisis se realizaron usando AAS, DRX, FTIR, TGA y DSC. En el espectro FTIR se observó que, en los sólidos con mayor cantidad de cobre, la banda del estiramiento O••H (M••OH, H••OH) se desplazó a valores más bajos de número de onda, debido a que la densidad electrónica de los grupos OH se orienta hacia el centro metálico de cobre. En todos los sólidos se observó la formación de la fase hidrotalcita, y de la fase Cu(OH)) en los sólidos con mayor contenido de cobre, lo que puede ser atribuido al efecto Jahn-Teller. Los resultados mostraron que los sólidos con mayor contenidode cobre colapsan en temperaturas menores. En todas las muestras se observaron eventos como:descomposición de la estructura HTLc, formación de óxidos metálicos y descomposición decarbonatos que quedaron ocluidos en los poros de los sólidos debido al colapso de la estructuralaminar.

Hydrotalcite-like compounds have been used in catalysis, medicine, environmental chemistry, and other applications. Depending on the metals present, the solids obtained by calcination can be used due to their basicity, memory effect, and high specific surface area. This study describes some characteristics of hydrotalcites based on Cu-Zn-Al. The solids were characterized by AAS, XRD, FTIR, DSC and TGA. In the FTIR spectra it was observed that in the solids with higher copper contents the band signed to O••H stretching (M••OH, H••OH) was moved to lower wave number values, because electron density of hydroxide groups orients toward the metallic copper center. In all materials hydrotalcite phase formation was observed and the Cu(OH)) phase in solids with higher copper content was detected, fact attributed to the Jahn-Teller effect. Results indicate that the collapse of the structure occurs at lower temperatures in the case of solids with higher copper content. In all the tested materials the decomposition of the HTLc structure and the formation ofmetal oxides was observed, as well as decomposition of carbonate ions occluded in the solid dueto the collapse of the lamellar structure.

Os compostos do tipo hidrotalcita podem ser usados nas áreas de catalise, medicina, química ambiental, entre outras. Dependendo dos metais presentes, os sólidos obtidos pela calcinação de hidrotalcitas também podem ser usados devido a propriedades tais como: caráter básico, efeito de memória e elevada área superficial especifica. Neste estudo descrevem-se algumas características das hidrotalcitas baseadas em Cu-Zn-Al. Na caracterização dos sólidos usaram-se astécnicas AAS, DRX, FTIR, TGA e DSC. Observou-se nos sólidos com maior conteúdo de cobre que o estiramento O••H (M••OH, H••OH) se desloca a valores menores de numero de onda, devido a que a densidade eletrônica dos grupos hidróxido se orienta em direção ao centro metálico de cobre. Em todos os materiais observou-se a fase hidrotalcita e nos sólidos com maior conteúdo de cobre foi detectada a fase Cu(OH)), fato atribuído ao efeito Jahn-Teller. Os resultados indicam que o colapso da estrutura acontece em temperaturas menores no caso dos sólidos com maior conteúdo de cobre. Em todos os materiais observaram-se decomposição da estrutura HTLc, formação de óxidosúmetálicos, e a decomposição dos íons carbonato que ficaram ocluídos nos sólidos devido ao colapsoda estrutura lamelar.

Therapeutic Effect and Mechanism of Hydrotalcite on Experimental Gastric Ulcer / 胃肠病学

Background:Hydrotalcite has been used in the treatment of gastric ulcer,but its mechanism is not clear. Aims:To investigate the efficacy and mechanism of hydrotalcite on experimental gastric ulcer in rats. Methods:Experimental acetic acid-induced gastric ulcer model was established in rats. Model rats were randomly assigned into control group,low and high dose hydrotalcite groups,and 0. 9% NaCl solution,880 mg·kg - 1 ·d - 1 ,1 230 mg·kg - 1 ·d - 1 hydrotalcite were intragastrically administrated,respectively. After 14 days,macroscopic examination was performed;and HE staining, CD31 staining and VG staining were used to evaluate the histological maturity,AB-PAS staining,level of hexosamine, immunohistochemical staining,serum levels of epidermal growth factor( EGF),prostaglandin E2( PGE2 )were used to evaluate the functional maturity. Results:Compared with control group,ulcer index(UI)was significantly decreased in high dose hydrotalcite group(P < 0. 05). Thickness of restored mucosa was significantly increased(P < 0. 05),number of cystically dilated gland was significantly decreased(P < 0. 01),microvessel density(MVD),collagen fiber,secretion of mucus,level of hexosamine,expressions of EGF,EGR receptor(EGFR)and PGE2 ,serum levels of EGF and PGE2 were significantly increased in low and high hydrotalcite groups( P < 0. 05,P < 0. 01). Conclusions:Hydrotalcite could obviously improve the histological and functional maturity of regenerative mucosa,as well as the quality of ulcer healing. The mechanism might be related to the neutralization of gastric acid,enhancement of mucus-HCO3 - barrier and up-regulation of expressions of EGF and PGE2 .

Effects of hydrotalcite on healing quality of active gastric ulcer with Helicobacter pylori infection / 中华消化杂志

Objective To observe the effects of hydrotalcite on histological ulcer healing quality in patients with Helicobacter pylori (Hp) positive active gastric ulcer .Methods A total of 145 patients with H p positive active gastric ulcer were divided into two groups .The control group was treated with esomeprazole ,amoxicillin and furazolidone triple therapy .The treatment group was treated with above triple therapy and hydrotalcite .After four-week treatment ,gastroendoscopy was repeated .The sections of gastric biopsy specimens were stained with hematoxylin-eosin (HE) staining ,Van Gieson staining , Alcian blue-periodic acid stiff (AB-PAS ) staining , streptavidin-perosidase (SP ) immunohistochemistry staining and computer imaging analysis technology were applied to observe maturity type of mucosal structure at the margin of ulcer ,the content of collagen and neutral mucus ,and the changes of expression of epithelial growth factor receptor (EGFR) and basic fibrobast growth factor (bFGF) before and after treatment .Paired samples t test was performed for comparison before and after treatment .F test and Chi-square test were used for comparison between two groups .Results The percentage of maturity type of regenerated mucosal structure of treatment group was 62 .9% (39/62) ,however that of control group was 40 .6% (26/64) ,and the difference was statistically significant (χ2 =13 .09 , P=0 .03) .Compared with those before treatment , the content of collagen in granulation tissue and neutral mucus in regenerated mucosa increased in both groups after treatment , and the increase was more significant in treatment group ((55 .1 ± 10 .4)% and (45 .8 ± 7 .1)% ,respectively);and the differences were statistically significant (F= 12 .85 and 18 .17 ,both P<0 .01) .Compared with those before treatment ,the percentage of EGFR and bFGF positive cells of both two groups increased , and the increase was more significant in treatment group ((49 .5 ± 8 .4)% and (48 .8 ± 9 .4)% ,respectively) ,and the differences were statistically significant (F=12 .17 and 18 .73 ,both P<0 .01) .Conclusion Hydrotalcite combined with anti-H p triple therapy can improve the maturity degree of structure and function of regenerated mucosa at the margin of ulcer in patients with H p positive active gastric ulcer and then improve the healing quality of ulcer .

Curative Effect Analysis of Hydrotalcite Combined with Omeprazole in the Treatment of Gastric Ulcer with Gastrorrhagia / 中国药师

Objective:To study the curative effect of hydrotalcite combined with omeprazole in the treatment of gastric ulcer with gastric bleeding. Methods:Seventy-six patients with gastric ulcer and bleeding in the stomach were selected and randomly divided into two groups. Thirty-two patients in the control group were treated with omeprazole alone while 44 patients in the observation group were treated with hydrotalcite combined with omeprazole. The therapeutic effects were compared between the two groups. Results:The total effective rate in the observation group was 100% while that was 87. 5% in the control group,and the difference between the two groups was statistically significant(P0. 05). Conclusion:Hydro-talcite combined with omeprazole in the treatment of gastric ulcer with gastric bleeding is effective and safe.

Cardiac Arrest Following Inadvertent Intravenous Administration of an Oral Antiacid: Hydrotalcite.

Emergency department overcrowding combined with shortage of experienced and knowledgeable healthcare staff may lead to fatal, albeit rare, malpractice cases in developing countries. We report herein a patient with cardiac arrest as a result of inadvertent intravenous injection of hydrotalcite, an orally administered anti-acid medication. Our literature search revealed no previous cases of cardiac arrest as a result of intravenous (IV) administration of hydrotalcite.

Efficacy of Domperidone Combined with Pantoprazole and Hydrotalcite Tablets in the Treatment of Bile Reflux Gastritis / 中国药师

Objective:To observe the curative effects of the combined application of domperidone, pantoprazole and hydrotalcite tablets in the treatment of bile reflux gastritis ( BRG) and explore the underlying mechanism. Methods:Totally 80 patients with BRG were randomly divided into the treatment group and the control group with 40 cases in each. The treatment group was received panto-prazole, hydrotalcite tablets and domperidone, and the control group was treated by hydrotalcite tablets and domperidone. The efficacy was observed in both groups after 4 weeks. Results:The effective rate of symptom relief in the treatment group and the control group was respectively 92. 5% and 62. 5% (P<0. 05). After the 4 week treatment, the gastritis healing rate in the treatment group was higher than that in the control group (P<0. 05). The improvement of gastric mucosal hyperemia, edema and erosion in the treatment group was better than that in the control group with significant difference (P<0. 05). Cholic acid in gastric juice and gastric acid se-cretion were significantly reduced in both groups after the treatment, while the reduction of gastric acid secretion in the treatment group was more notable than that in the control (P<0. 05). Conclusion:Pantoprazole can be used to control BRG, and the combination of the three drugs shows better efficacy in the treatment of BRG.

Hydrotalcite combined with proton pump inhibitor in treatment of post endoscopic submucosal dissection ulcer: a randomized, controlled clinical trial / 中华消化内镜杂志

Objective To evaluate the therapeutic efficacy of a combination of proton pump inhibitor(PPI) and hydrotalcite for endoscopic submucosal dissection (ESD) induced ulcer.Methods Eightyone consecutive patients who underwent ESD were randomly assigned to either the group of PPI and hydrotalcite therapy ( drug combination group,n =41 ) or the PPI group ( n =40).Delayed bleeding rates were monitored and compared.The main upper abdomen symptoms 1-wk later and ulcer healing rates and ulcer diameter 4-wk later were compared between the two groups.Results There was no significant difference in delayed bleeding rate (P ＞ 0.05 ).At the end of first week after ESD,the combination therapy was significantly more effective than the PPI alone in reducing frequencies and severity of upper abdominal pain and upper abdominal distention,while there was no significant difference between the two groups in relieving belch and nausea.A better ulcer healing rates and a smaller ulcer diameter were observed in the combination group at the end of 4 weeks ( P ＜ 0.05 ).Conclusion The combination therapy of hydrotalcite and PPI can relieve upper abdominal symptoms and improve the healing rate of ESD induced ulcer.

Efecto del vanaiio en catalizadores derivados d materiales tipo hidrotalcita een deshidrogenación oxidativa de propnoo / Effect ofvanadiuum in catalysts derived fom hydrotalcite-like materials in oxidative dehidrogenation of propnee / Efeito dovanádioo em catalisadores derivaos de materiais tipo hidrotalciita na desidrogenação oxidativa de propano

Dos nuevos materiales tipo hidrotalcita, basados en NiCoCr y NiCoFe, se obtuvieron por el método hidrotérmico. Estos materiales se modificaron con especies de vanadio por intercambio iónico. Los sólidos se caracterizaron usando difracción de rayos X (DRX), análisis elemental (absorción atómica), y análisis termogravimétrico (ATG). Los sólidos con y sin intercambio se trataron térmicamente para obtener los respectivos óxidos mixtos, que posteriormente se evaluaron en la reacción de deshidrogenaciónoxidativa de propano (Dhop) a una velocidad espacial de 50 mL/min g y en un rango de temperatura comprendido entre 250 y 500 °C. Los estudios catalíticos mostraron un efecto positivo al incorporar el vanadio para el material NiCoCr, mientras que para el sistema NiCoFe modificado se observó una disminución en su actividad catalítica.

Two novel hydrotalcite-like materials have been synthesized by hydrothermal treatment. Using ionic exchange method, the materials have been modified with vanadium species. Characterization of the materials was carried out by X-Ray diffraction (XRD), chemical analyses (atomic absorption), and Thermogravimetric analyses (TGA). Modified and non-modified materials have been calcined in order to obtain respective mixed oxides, which were tested in oxidative dehydrogenation of propane (ODHP) at a space velocity of 50 mL/min g with a temperature range between 250-500 °C. The catalytic studies showed a positive effect by incorporating vanadium for NiCoCr system, while for the NiCoFe modified system a decrease in catalytic activity was shown.

Dois novos materiais tipo hidrotalcita baseados em NiCoCr e NiCoFe obtiveram-se pelo método hidrotérmico. Esses materiais foram modificados com espécies de vanádio por troca iô nica. Os materiais caracterizaram-se usando difração de raios X (DRX), análise elementar (absorçãoatômica) e análisetermogravimétrica (ATG). Os sólidos com e sem troca foram tratados termicamente para obter os respectivos óxidos mistos, que posteriormente se avaliaram na reação de desidrogenaçãooxidativa de propano (DHOP) a uma velocidade espacial de 50 mL/min g e em uma faixa de temperatura entre 250 a 500 °C. Os estudos catalíticos mostraram um efeito positivo ao incorporar o vanádio para o material NiCoCr, enquanto para o sistema NiCoFe modificado foi observada uma diminuiçãona sua atividade catalítica.

Comparative study on rabeprazole and hydrotalcite in treatment of patients with bile-reflux gastritis after cholecystectomy / 中华消化杂志

Objective To compare the efficacy of rabeprazole and hydrotalcite in treatment of patients with bile-reflux gastritis after cholecystectomy.MethodsPatients,who underwent cholecystectomy and were confirmed with bile reflux gastritis by 24 h gastric bilirubin monitoring,were enrolled in the study.Patients were randomly assigned into control group (n=30),rabeprazole group (n= 30,20 mg daily),hydrotalcite group (n= 29,1.0 g three times daily) and rabeprazole combined with hydrotalcite group (combination group,n= 31) and treated for 8 weeks.Dyspeptic symptoms of abdominal pain,bloating,heartburn and bitter taste were observed.The endoscopic and histological examination were performed 2 weeks after treatment to evaluate the improvement of inflammation and histological activity.The 24 h bilirubin monitoring was used to assess the total per cent of bilirubin absorption (value of 0.14 units or greater) time,the number of reflux episodes and the number of reflux episodes lasting longer than 5 min.Results The dyspeptic symptoms were relieved in three groups after treatment.However,the endoscopic oedema (2.11 ±0.77 vs 1.50 ±0.67,P<0.05) and the histological activity (2.87±0.72 vs 1.97±0.78,P<0.05) as well as the number of reflux episodes> 5 min (18.26+ 1.80 vs 9.70± 1.20) were improved most significantly in combination group after treatment.There was no statistical difference in rabeprazole and hydrotalcite groups before and after treatment.Whereas the total percent time of bilirubin absorption value >0.14 decreased in three treatment groups after treatment (P<0.05).Conclusion Rabeprazole combined with hydrotalcite is effective in the treatment of patients with bile reflux gastritis after cholecystectomy.

Evaluation of hydrotalcite in treatment of functional dyspepsia epigastric pain syndrome: a multicenter randomized open positive controlled clinical trial / 中华消化杂志

Objective To evaluate the clinical efficacy and safety of hydrotalcite chewable tablets in treatment of patients with functional dyspepsia epigastric pain syndrome(EPS), and to investigate the onset time of hydrotalcite after the first dosage and whether use of hydrotalcite in EPS is a costeffective strategy. Methods A multicenter, randomized, open, positive controlled clinical trial was carried out in 240 patients with EPS. The subjects randomly received eigher hydrotalcite or omeprazole for 2 weeks. The improvemcnt and the disappear time of symptoms were evaluated before and after treatment and cost-effective was analyzed between two groups. Results It was demonstrated that both hydrotalcite and omeprazole could relief symptoms after treatment. After treatment for 2 weeks, the total effective rate was 85. 71% in hydrotalcite group and 90. 43% in omeprazole group with no significant difference (P＞0.05). The median onset time of hydrotalcite after first dosage was 0.417 h. The overall direct cost per patient was RMB ￥122. 29 for hydrotalcite treatment and RMB ￥242.95 for omeprazole treatment. The main adverse events included diarrhea, thirst, bloating,headache and belching. No severe adverse event was found in two groups. Conclusions Hydrotalcite has fast effect on relief of EPS symptoms. Use of hydrotalcite is a cost-effective strategy in the management of EPS. It is a safe and effective medicine in treatment of EPS.

Study of Dimethyl Carbonate Adsorption and Activation on Solid Bases by Fourier Transform Infrared Spectroscopy / 分析化学

The adsorption and activation of dimethyl carbonate on the surface of solid base were investigated by in situ FTIR, and the solid bases included magnesia, magnesium fluoride, Mg-Al mixed oxide and fluorine-modified Mg-Al mixed oxide. The FTIR results showed that dimethyl carbonate adsorbed on the surface of solid based by two modes of bidentate and unidentate complex. The bidentate was more active than the unidentate. Methoxyl group was formed from the adsorbed dimethyl carbonate on the surface of magnesia and Mg-Al mixed oxide. And fluomethyl group was formed from the adsorbed dimethyl carbonate on the surface of sodium fluoride. However, dimethyl carbonate on the surface of fluorine-modified Mg-Al mixed oxide showed preference for generating fluomethyl group. With the increasing of the treating temperature of samples, the methoxyl group was gradually formed on the surface. Accordingly, the fluorine-modified Mg-Al mixed oxide was found to be an excellent catalyst for methylation.

Effect of Weidongfang and hydrotalcite on bile reflux gastritis / 中国基层医药

Objective To observe the effect of Weidongfang and hydrotalcite in treatment of bile reflux gastrifis.Methods Bile reflux gastritis were randomly assigned to 2 groups.30 eases in the Weidongfang group were treated with Weidongfang and hydrotalcite;30 cases in the mosapride group were treated with mosapride and hydrotalcite;and the course of treatment was 4 weeks for all.The clinical symptoms of bile reflux gastritis,the classify of extent of bile reflux and the accumulated points of pathological change of the gastric mucosa below gastroscope were evalumed before and after treatment.Results The significant and total effective rate in the Weidongfang group were 33.3% and 86.7%.Mosapride group 43.3% and 83.3%.Butthe classify of extent of bile reflux and the accumulated points of pathological change of the gastric mucosa of Weidongfang group were Similar to Mosapfide group below gastroscope.Conclusion Weidongfang and hydrotalcite were effective medicine in treatment of bile reflux gastritis.

Effects of mucosal protective agents against experimental gastric mucosal lesions and ultra-structure changes in gastric mucosal in rats / 中华消化杂志

Objective To evaluate the protective effects of hydrotalcite,Marzulene-s,selbex,gefarnate,sucralfate and rebamipide against the gastric mucosa lesions induced by ethanol,aspirin,hydrochloric acid or prednisolone in rats.The changes in intercellular space width of gastric epithelial in rats was observed. Methods Four kinds of models were used to observe the protective effects of six agents against the gastric mucosal lesions.① Ethanol model:a total of 84 male Wistar rats were divided into 7 groups with 12 each. The rats in group 1 to 7 were orally received hydrotalcite,Marzulene-S,gefarnate,sucralfate,rebamipide or normal saline for 3 days,respectively.On day 4,the rats were given 1 ml of absolute ethanol.The length of gastric lesion were measured by ulcer index.② Aspirin model:the rats were received 300 mg/kg of aspirin and 0.1 mol/L hydrochloric acid (0.5 ml/100 g).The following procedures were as ①.③ Hydrochloric acid model:the rats were received 1 ml of 0.7 mol/L hydrochloric acid. The following procedures were as ①. ④ Prednisolone model: all groups were administrated with above 6 agents or normal saline for 5 days.During the 2nd-5th day,the rats were subcu aneously injected with prednisolone (250 mg/kg) daily. Rats were killed on 5th day,and the lesions were mcasured by ulcer index.Gastric mucosal tissue of No.1,5 and ]0 rat in the control group and the hydrotalcite group were picked up to measure the intercellular space width using transmission electron microscopy. Results In four kind of models,the ulcer index were significantly lower in rats treated with mucosal protective agents than that in the controls (P＜0.05),expecially in hydrotalcite group (P＜0.01).The width of intercellular space in the hydrotalcite group was significantly narrower than that in controls (P＜0.05).Conclusions All of the mucosal protective agents can be against the gastric mucosal lesion induced by ethanol,hydrochloric acid,aspirin or prednisolone.Among them,the hydrotalcite is even better.The effect of hydrotalcite is further confirmed by observation of intercellular space width.

Induced Mutagenesis of High Lipase Productivity Strain and Immobilization of Produced Lipase / 中国生物工程杂志

A mutant strain RZ13 with high lipase productivity was obtained through treating the Rhizopus sp. RXF12 by UV and microwave,and its activity was 2.62-fold of the original one. The high lipase productivity of the mutant strain could be inherited after repetitious subcultures.The optimal culture conditions of the RZ13 for producing lipase were studied.The lipase with highest activity (67.32U/ml) was obtained on the conditions of 25℃,pH 8.0,5 %(v/v) single spore suspension (1?107spore/ml) and 120 r/min for 84h,and stable under 40℃ and pH 8.5. In addition,the lipase was immobilized by adsorption onto Mg-Al hydrotalcite at 25℃ for 4 h by screening carriers and optimizing the immobilization. The results showed that the optimal reaction temperature and pH were 35~55℃ and 7.5~9.0,respectively,much wider than the free lipase.