The heme oxygenase-1 gene polymorphisms modulate on neonatal hyperbilirubinemia / 中国医师杂志

The role of genetic factors in the modulation of serum bilirubin levels and the pathophysiology of neonatal hyperbilirubinemia is being increasingly recognized.Heme oxygenase-1 (HO-1) is the rate-limiting enzyme by which heme is catabolized to biliverdin and thence to bilirubin,with the simultaneous release of equimolar quantities of ferrous iron (Fe3 +) and carbon monoxide.Polymorphisms of the HO-1 gene promoter may modulate transcriptional activity,thereby augmenting or attenuating HO-1 expression with resultant modulation of the production of bilirubin.At present,some articles have elucidated the role of these polymorphisms in neonatal bilirubin production,but in different races,the results are different.