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1.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1513618

ABSTRACT

Introducción: Las infecciones del tejido óseo por gérmenes patógenos por la vía hematógena son frecuentes en el niño en las zonas metafisarias y columna vertebral en el adulto. Objetivo: Presentar el caso de una paciente adulta con osteomielitis del fémur por vía hematógena. Caso clínico: Paciente de 38 años de edad, blanca, femenina sin comorbilidad conocida, la cual acude a la consulta de Ortopedia y Traumatología por referir dolor intenso a nivel del muslo derecho que no remite al tratamiento ambulatorio con analgésicos. Mediante la exploración física se observó ligero aumento de volumen a nivel del muslo distal. A la palpación se detectó hiperestesia cutánea en especial hacia la cara lateral. La tomografía axial computarizada detectó a nivel de la diáfisis distal del fémur derecho, lesión osteolítica con presencia de una hiperdensidad en su interior con densidad ósea. Al tener en cuenta todos los elementos anteriores, se decide llevar la paciente al quirófano, para tratamiento de tipo quirúrgico, donde se realizó incisión quirúrgica lateral en la zona distal del muslo derecho, se avanzó por planos quirúrgicos y se realizó punción ósea con trocar de ocho milímetros donde se observó salida de pus espeso. Conclusiones: La osteomielitis hematógena es una enfermedad típica del paciente con epífisis abiertas y en la columna vertebral del adulto. La invasión al tejido óseo por la vía hematógena en el adulto que no sea en la columna es muy infrecuente.


Introduction: Infections of the bone tissue by pathogenic germs by hematogenous route are frequent in the child in the metaphyseal zones and in the spine in the adult. Objective: To present an adult patient with osteomyelitis of the femur by hematogenous route. Clinical case: A 38-year-old white female patient with no known morbidity, clinical record 253853, named MRA, who went to the Orthopedics and Traumatology clinic for reporting severe pain at the level of the right thigh that did not respond to treatment with ambulatory pain relievers. Physical examination revealed a slight increase in volume at the level of the distal thigh. On palpation, skin hyperesthesia was detected, especially towards the lateral aspect of the knee. A computed tomography scan detected an osteolytic lesion at the distal diaphysis of the right femur with the presence of hyperdensity with bone density. Taking all the above elements into account, it was decided to take the patient to the operating room for surgical treatment, where a lateral surgical incision was made in the distal area of the right thigh, surgical plans were performed, and an eight millimeters trocar bone puncture was used to open the bone where thick pus was observed. Conclusions: Hematogenous osteomyelitis is a typical entity of the patient with open epiphyses and in the adult spine. Invasion of bone tissue by the hematogenous route in adults other than in the spine is very rare.

2.
Article | IMSEAR | ID: sea-218486

ABSTRACT

Background: Loss of hard tissues is diverse in its localization and can manifest itself in the area of one, several or all of the patient's teeth, one of the most serious consequences of this pathology is a decrease in the height of the lower third of the face. Materials and Methods: The paper presents the results of a comprehensive dental examination and survey data of 98 patients. During the study, patients were divided by age groups, gender characteristics, pathological disorders and depending on the plane of erasure (horizontal, vertical, mixed) teeth. The prevalence and factors of the development of increased abrasion of hard tissues of teeth were determined. Conclusion: Local exogenous and general endogenous factors turned out to be a more frequent cause of increased tooth abrasion for residents of the city of Kaspiysk.

3.
Rev. otorrinolaringol. cir. cabeza cuello ; 82(1): 101-113, mar. 2022. ilus, tab
Article in Spanish | LILACS | ID: biblio-1389819

ABSTRACT

Resumen La hiperacusia corresponde a la excesiva sensibilidad auditiva o intolerancia a ciertos sonidos cotidianos que para la mayoría de las personas parecerían habituales. Considerando los mecanismos fisiológicos involucrados en el origen de la hiperacusia, es lógico pensar que su presencia podría afectar algunas habilidades del procesamiento auditivo central, sin embargo, la evidencia en torno al tema es escasa y no existe actualmente una revisión de la literatura que agrupe las investigaciones sobre esta temática. Por ello, el presente estudio pretende identificar y analizar la evidencia científica disponible sobre la relación entre hiperacusia y desorden del procesamiento auditivo central. Se realizó una revisión de la literatura guiada por protocolo PRISMA en las bases de datos Proquest, Ebsco, Pubmed, ScienceDirect, Cochrane Library y Scielo de acuerdo con términos claves. Fueron incluidos artículos originales de investigación, revisiones sistemáticas y metaanálisis, publicados desde el año 2010, realizados en animales y humanos, escritos en idiomas inglés, español y portugués. Se encontraron 323 estudios relacionados con los términos claves utilizados, de los cuales 13 cumplieron con los criterios de inclusión y fueron analizados. Se puede concluir que la evidencia científica en torno al tema es escasa e incipiente. Estructuras de la vía auditiva central como núcleos cocleares, lemnisco lateral, colículos inferiores, cuerpo geniculado medial y corteza auditiva primaria estarían relacionadas con la hiperacusia, así como también habilidades de procesamiento auditivo de figura/fondo, ordenación temporal y transferencia interhemisférica se verían afectadas.


Abstract Hyperacusis has been defined as the excessive auditory sensitivity or intolerance to certain everyday sounds that seem common for most people. Considering the underlying physiological mechanisms of hyperacusis, it is reasonable to think that it could affect some abilities involved in the central auditory processing. However, there is lack of evidence about this topic, and there is no literature review that gathers all the existing research. Therefore, the current study intends to identify and analyze the available scientific evidence regarding the relationship between hyperacusis and central auditory processing disorder. The review of the literature followed the PRISMA protocol, using key words in Proquest, Ebsco, Pubmed, ScienceDirect, Cochrane Library and Scielo databases. Original research articles, systematic reviews and meta-analyses of studies made with human and animals that have been published since 2010 in English, Spanish and Portuguese were included. Among them, 323 studies were related to the key terms, out of which 13 met the inclusion criteria and were analyzed. It is possible to conclude that there is little and incipient scientific evidence on the topic. Structures of the central auditory pathway such as cochlear nuclei, lateral lemniscus, inferior colliculi, medial geniculate body and primary auditory cortex seem to be related to hyperacusis; auditory processing skills such as figure/ground discrimination, temporal ordering and interhemispheric transfer appear to be affected as well.


Subject(s)
Humans , Animals , Hyperacusis/etiology , Hyperacusis/epidemiology , Auditory Perceptual Disorders/etiology , Auditory Perceptual Disorders/epidemiology , Prevalence
4.
Chinese Acupuncture & Moxibustion ; (12): 943-950, 2021.
Article in Chinese | WPRIM | ID: wpr-920990

ABSTRACT

Although acupuncture has spanned thousands of years in the history of traditional medicine, still some basic questions are not clarified. Acupuncture is the theory based on long time medical practice of the ancient sage, combined with objectivesymptom and medical expertise from diseases, and being applied for the instruction in clinic. In this way, acupoint is discovered by doctors in the practice of disease treatment other than a natural occurrence in the healthy population. And acupoint specificity is attached to the target organ involved in pathological condition. In our opinion, acupoint originates from somatic referred area reactive to visceral disorders. And accordingly, referred hyperesthesia of the somatic area is phenomenon of acupoint sensitization. Acupoint is the situ having health code formed in the biological evolution. Corresponding acupoint of a given organ is the alarmer for the state of health, and also is the trigger for self-healing where acupuncture can work as a gating-button. Therefore, acupoint must be accompanied with diseases in that it is reinforced by, relayed on, responsive to and neutralize by the pathological course. In conclusion, acupoint cannot exist without the disease. In another word, acupoint will be unshown, or be functionally hidden, under physiological condition.


Subject(s)
Humans , Acupuncture , Acupuncture Points , Acupuncture Therapy , Medicine, Traditional , Physicians
5.
Medisan ; 24(6) tab
Article in Spanish | LILACS, CUMED | ID: biblio-1143259

ABSTRACT

Introducción: La hiperestesia dentinaria es una sensación dolorosa de intensidad variable, que va de leve a moderada y, al encontrarse la dentina expuesta, puede convertirse en una molestia constante. Objetivo: Determinar la alternativa menos costosa en el tratamiento de pacientes con hiperestesia dentinaria. Método: Se realizó una evaluación económica completa del tipo minimización de costo, en la Clínica Estomatológica Provincial Docente Mártires del Moncada de Santiago de Cuba, desde enero hasta mayo de 2019. Se revisaron 40 historias clínicas, escogidas a conveniencia, ya que contaban con los datos necesarios para la investigación. Se crearon 2 grupos de estudios, cuyos integrantes fueron tratados con laca flúor y láser, respectivamente. Se analizaron las variables de edad, sexo, efectividad de los tratamientos, costo directo e indirecto y costo unitario. Resultados: En la serie predominaron el grupo etario de 15-24 años (30,0 %), seguido por el de 25- 34 (25,0 %), así como el sexo femenino (70,0 %). El costo unitario del tratamiento con laca flúor fue de $7,77 y con láser de $5,74, para una diferencia de $2,03. Conclusión: La alternativa menos costosa en el tratamiento de pacientes con hiperestesia dentinaria resultó ser la aplicación de láser; mientras que la evaluación económica realizada demostró ser apropiada en materia de eficiencia económica.


Introduction: Dentin hyperesthesia is a painful sensation of variable intensity that goes from light to moderate and, as dentin is exposed, it can become a constant discomfort. Objective: To determine the less expensive alternative in the treatment of patients with dentin hyperesthesia. Method: A complete economic evaluation of the cost minimization type was carried out in Martires del Moncada Teaching Provincial Stomatological Clinic in Santiago de Cuba, from January to May, 2019. Forty medical records were reviewed, chosen of convenience, since they had the necessary data for the investigation. Two groups of studies were created whose members were treated with lacquer fluorine and laser, respectively. The age, sex, effectiveness of the treatments, direct and indirect cost and unitary cost variables were analyzed. Results: In the series there was a prevalence of the 15-24 age group (30.0 %), followed by that of 25-34 (25.0 %), as well as the female sex (70.0 %). The unitary cost of the treatment with lacquer fluorine was of $7.77 and with laser of $5.74, for a difference of $2.03. Conclusion: The less expensive alternative in the treatment of patients with dentin hyperesthesia was the laser application; while the economic evaluation carried out demonstrated to be appropriate as regards economic efficiency.


Subject(s)
Hyperesthesia/therapy , Costs and Cost Analysis , Laser Therapy , Fluorine
6.
Rev. bras. oftalmol ; 78(3): 192-194, May-June 2019. graf
Article in English | LILACS | ID: biblio-1013665

ABSTRACT

ABSTRACT This study aims to describe a challenging clinical case of a patient with a neurotrophic and exposure corneal ulcer. A 75-year-old male patient, with history of right eye (RE) limbic stem-cell insuficiency due to complications of recurrent herpetic keratitis, underwent successful limbic stem-cell transplantation in 2008. In 2010, an uneventful penetrating keratoplasty was performed. After a cataract phacoemulsification surgery with intraocular lens implantation done in 2011, best corrected visual acuity was 20/20, and remained stable until 2015. In July 2015, the patient developed right facial nerve palsy and two months later, presented with an extensive central corneal ulcer, with a significant thinning of central stroma, without infection signs, but with an imminent risk of perforation. Treatment with topical ofloxacin and intensive ocular lubrification was started in association with permanent ocular oclusion. Due to lack of any clinical improvement, treatment with RGTA [Poli (carboximetilglucose) sulfate, dextrano T40] (Cacicol®, Thea) was started. After two weeks of treatment, a complete reepithelization and partial stromal filling was observed. Continued monitoring and treatment with artificial tears was maintained, with no recurrence observed. There is an unmet need for a medical therapy that could help corneal neurotrophic ulcers to heal. The presented clinical case shows that the approach of targeting extracellular matrix can be effective in the reepithelialization of neurotrophic and exposure corneal ulcer that do not respond to conventional treatments.


RESUMO Este trabalho relata um caso clínico desafiante de doente com uma úlcera de córnea neurotrófica e de exposição. Doente do sexo masculino, de 75 anos, com antecedentes de queratites herpéticas de repetição no olho direito (OD), complicadas com o desenvolvimento de uma insuficiência límbica, foi submetido com sucesso a transplante de células límbicas em 2008. Em 2010 foi submetido a queratoplastia penetrante e em 2011, após realização de cirurgia de catarata, apresentava uma melhor acuidade visual corrigida (MAVC) de 20/20. A MAVC manteve-se estável até Julho de 2015, altura em que desenvolveu paresia facial periférica à direita. Dois meses depois, o doente desenvolveu uma úlcera de córnea central extensa, com adelgaçamento significativo do estroma central, sem sinais de infeção, mas com risco iminente de perfuração. Foi iniciado tratamento tópico com ofloxacina, lubrificação intensiva e oclusão ocular contínua. Por ausência de melhoria clínica, foi iniciado tratamento tópico com um RGTA [Poli (carboximetilglucose) sulfato, dextrano T40] (Cacicol®, Thea). Após duas semanas de tratamento, observou-se uma reepitelização completa e regeneração parcial do estroma. Foi mantida monitorização regular e tratamento com lágrimas artificiais, sem recidiva do quadro clínico. Há uma grande necessidade de tratamentos médicos que possam ajudar na regeneração de úlceras de córnea neurotróficas e de exposição. O caso clínico apresentado sugere que os fármacos que têm por alvo a matrix extracelular poderão ser eficazes na reepitelização de úlceras de córnea neurotróficas e de exposição que não respondem ao tratamento convencional.


Subject(s)
Humans , Male , Aged , Regeneration/drug effects , Corneal Ulcer/drug therapy , Glycosaminoglycans/administration & dosage , Ophthalmic Solutions/administration & dosage , Stimulation, Chemical , Wound Healing , Administration, Topical , Dextrans/administration & dosage , Hypesthesia , Anti-Infective Agents/administration & dosage
7.
Rev. odontol. Univ. Cid. São Paulo (Online) ; 31(2): 155-167, abr/jun 2019. il.
Article in Portuguese | LILACS, BBO | ID: biblio-1021796

ABSTRACT

A hiperestesia dentinária cervical se caracteriza como uma manifestação com sintomatologia dolorosa aguda, repentina, localizada e de curta duração, provocada por um estímulo tátil, químico, térmico ou osmótico. Cessa após a remoção e não é provocada em dentes saudáveis por estímulos considerados fisiológicos. Acomete geralmente o terço cervical dos elementos dentários como pré-molares e molares, com exposição da dentina e abertura dos túbulos dentinários após recessão gengival, perda de estrutura cementária ou adamantina, lesões não cariosas, hábitos deletérios, entre outros. Devido à alta prevalência dessa condição na população mundial e queixas frequentes no consultório odontológico, a hiperestesia tem sido exaustivamente estudada. O objetivo deste trabalho, por meio de revisão de literatura, é elucidar a etiologia, diagnóstico diferencial, terapias e efetividade no controle desse problema de saúde pública


The cervical dentinal hyperesthesia is characterized as a manifestation with sharp, sudden, located painful symptomatology and of short duration, provoked by a stimulus tactile, chemical, thermal or osmotic. It ceases after the removal and it isn´t provoked in healthy teeth by stimulus considered physiologic. It usually attacks the cervical third of the dental elements as premolar and molars, with exhibition of the dentine and opening of the dentinal tubules after gingival recession, loss of cementery or adamantine structures, non-carious lesions, harmful habits, among others. Due to the high prevalence of that condition in the world population and frequent complaints in the dentistry clinic, the hyperesthesia has been exhaustively studied. The aim of this paper, through review of literature, was to elucidate the aetiology, differential diagnosis,therapies and effectiveness in the control of that problem of public health


Subject(s)
Hyperesthesia , Therapeutics , Dentin Desensitizing Agents
8.
CCH, Correo cient. Holguín ; 22(4): 571-582, oct.-dic. 2018. tab
Article in Spanish | LILACS | ID: biblio-974512

ABSTRACT

Introducción: la hipersensibilidad dentinaria es un problema de salud bucal en la población adulta, como una respuesta exagerada frente a los estímulos sensitivos, táctiles, térmicos, químicos u osmóticos, que afectan a la dentina expuesta con túbulos abiertos y permeables. Se presenta como una sensación dolorosa desde leve a moderada, que puede llegar a convertirse en una molestia constante. Objetivo: caracterizar el comportamiento de la hiperestesia dentinaria en un área de salud, en adultos de 15 a 58 años. Métodos: se realizó una investigación transversal en adultos de 15 a 58 años, del área de salud de la Clínica Estomatológica de Mayarí, que acudieron a la consulta de urgencia desde septiembre del 2014 a mayo del 2016. El universo estuvo constituido por el total de pacientes atendidos por urgencia en dicho período (n=418), y la muestra por 180 pacientes que presentaron la enfermedad. Resultados: el sexo más afectado fue el femenino con el 65,6%; principalmente en el grupo de 37 a 47 años con predominio de la hiperestesia localizada hasta el 92,2%. La cara vestibular fue la más afectada con el 78,9%. Los factores desencadenantes más frecuentes fueron: la recesión periodontal hasta 72,2% y los alimentos ácidos en un 63,3%. Conclusiones: el dolor moderado fue el más frecuente, y la recesión periodontal el factor desencadenante más representativo.


Introduction: dentin hypersensitivity is an oral health problem in the adult population. It has been defined as an exaggerated response to sensitive, tactile, thermal, chemical or osmotic stimuli. It affects exposed dentine with open and permeable tubules with a painful sensation from mild to moderate, which can become a constant discomfort. Objective: to characterize the behavior of dentine hyperesthesia in adults from 15 to 58 years old, form a health area. Methods: a cross-sectional investigation was carried out in adults from 15 to 58 years old, attended at the emergency Mayarí Stomatological Clinic health area, from September 2014 to May 2016. Universe was constituted by the total of patients in that period (n=418), and the sample was made up by 180 patients who presented the disease. Results: female were the most affected with 65.6%; mainly in the group from 37 to 47 years old, with localized hyperesthesia up to 92.2% and vestibular face was reached 78.9%. Periodontal recession raised to 72.2% and acidic foods with 63.3%, were the two most frequent triggers. Conclusions: moderate intensity pain was the most frequent. The most representative precipitating factor was periodontal recession.

9.
Rev. cuba. estomatol ; 54(2): 1-12, apr.-jun. 2017. ilus
Article in Spanish | LILACS | ID: biblio-901032

ABSTRACT

Introducción: la hiperestesia dentinaria se caracteriza por un dolor intenso y breve asociado a la exposición de estímulos térmicos, táctiles, osmóticos o químicos. De prevalencia creciente, reduce la calidad de vida del paciente. Objetivo: evaluar la eficacia, aceptabilidad y tolerancia de un dentífrico con dióxido de silicio obliterante, nitrato potásico y monofluorofosfato sódico en pacientes con hiperestesia dentinaria. Métodos: estudio observacional y longitudinal (n= 22) en el que se aplicó el dentífrico 3 veces/día durante 28 días. Se realizó una evaluación clínica, antes y después de la aplicación, a las 48 horas, a las 96 horas y los días 7, 14, 21 y 28 del estudio. Se evaluó su eficacia en términos de reducción de la hipersensibilidad dental determinada mediante técnica táctil (escala de calificación verbal) y de chorro de aire (escala de Schiff). En cada visita se valoró la tolerancia del producto. Los pacientes valoraron el grado de hipersensibilidad y su percepción del producto mediante un cuestionario de evaluación subjetiva. El estudio se realizó bajo los principios de Buena Práctica Clínica. Resultados: la hipersensibilidad dental se redujo en todos los puntos temporales del estudio y fue significativa (p< 0,05) a partir del día 5. Esta mejoría fue sostenida y aumentó a medida que avanzó el tratamiento. El día 29 la hipersensibilidad media se redujo en un 85 por ciento respecto al valor basal en todos los pacientes. El 91 por ciento de los participantes opinó que el dentífrico había cumplido sus expectativas. No se observó ninguna reacción adversa derivada del uso del producto. Conclusiones: el dentífrico, administrado 3 veces/día, consiguió una reducción de la hipersensibilidad dental, significativa a partir del día 5, que fue aumentando con el tiempo. El producto presentó muy buena aceptabilidad y tolerancia(AU)


Introduction: dentin hypersensitivity is characterized by sharp pain of short duration associated with exposure to thermal, tactile, osmotic or chemical stimuli. Dentin hypersensitivity is a disorder of growing prevalence which reduces the quality of life of patients. Objective: evaluate the efficacy, acceptability and tolerance of a toothpaste with precipitated silica, potassium nitrate and sodium monofluorophosphate in patients with dentin hypersensitivity. Methods: an observational longitudinal study was conducted (n= 22) in which the toothpaste was applied 3 times a day for 28 days. Clinical assessment was performed before and after the application, at 48 hours, at 96 hours and on days 7, 14, 21 and 28 of the study. Efficacy was evaluated in terms of dental hypersensitivity reduction as determined by tactile (Verbal Rating Scale) and air jet (Schiff scale) techniques. Tolerance to the product was assessed in every visit. Patients ranked the degree of hypersensitivity and their perception of the product by means of a subjective assessment questionnaire. The study complied with Good Clinical Practice principles. Results: areduction was observed in dental hypersensitivity at all time points throughout the study, and it was significant (p< 0,05) as of day 5. This improvement was sustained and increased as treatment progressed. On day 29 mean hypersensitivity had reduced 85 percent with respect to baseline value in all patients. 91 percent of the patients stated that the toothpaste had met their expectations. No adverse reaction attributable to the product was observed. Conclusions: applied 3 times/day, the toothpaste obtained a reduction in dental hypersensitivity, which was significant as of day 5. This improvement increased over time. The product had very good acceptability and tolerance(AU)


Subject(s)
Humans , Silicon Dioxide/administration & dosage , Dentifrices/administration & dosage , Dentin Sensitivity/etiology , Hyperesthesia/etiology , Longitudinal Studies , Observational Study
10.
Anesthesia and Pain Medicine ; : 286-289, 2017.
Article in English | WPRIM | ID: wpr-145716

ABSTRACT

Greater auricular nerve neuropathy is a reported as complication in some cases of shoulder arthroscopy in the beach chair position using a horse-shoe headrest. Due to this risk, intubation pad-type headrest is recommended for the beach chair position, to effectively prevent greater auricular nerve palsy. In this case report, we described a patient who experienced greater auricular nerve neuropraxia after open reduction and internal fixation with plate of clavicular fracture in beach chair position using an intubation pad-type headrest. A 49-year-old man was diagnosed with left clavicular fracture without accompanying injury or complication. He underwent an operation for open reduction and internal fixation with a plate. After surgery, the patient reported numbness, and a tingling sensation without pain or skin lesion in the auricular area and the lower margin of the left mandible. Based on the clinical symptoms, greater auricular nerve neuropraxia was diagnosed. The symptoms disappeared completely after four weeks of outpatient follow-up.


Subject(s)
Humans , Middle Aged , Arthroscopy , Follow-Up Studies , Hyperesthesia , Hypesthesia , Intubation , Mandible , Nerve Compression Syndromes , Outpatients , Paralysis , Patient Positioning , Postoperative Complications , Sensation , Shoulder , Skin
11.
Chinese Journal of Digestion ; (12): 337-342, 2016.
Article in Chinese | WPRIM | ID: wpr-493499

ABSTRACT

Objective To investigate the role of mucosal mast cells infiltration and degranulation with nerve growth factor (NGF)in development of visceral hypersensitivity in Sprague-Dawley (SD)rats. Methods The model of visceral hypersensitivity of irritable bowel syndrome (IBS)was established in 19 neonate SD rats with intestinal stimulation (rectalballon distention)on 8th,10th and 12th postnatal days. The other 19 neonate SD rats without colonic distention were assigned to the control group.After rats grew up (six to eight weeks old),the visceral sensitivity was tested by abdominal withdrawal reflex (AWR)in 10 rats of each group.Mast cell infiltration and degranulation were observed with toluidine blue staining in colon tissue slides.The NGF level of intestinal tissues was detected by enzyme-linked immunosorbent assay (ELISA)methods in the left nine rats of each group.The culture system of dorsal root ganglias (DRG)from the neonatal rats was set up.The changes of electrophysilogical characters of DRG stimulated with NGF (100 ng/mL)for four days were recorded with patch-clamp.Paired t test was performed for comparison between groups.Results The results of AWR indicated that neonatal colonic stimulation could significantly increase visceral sensitivity after growing up.Under 20,40 and 60 mmHg (1 mmHg=0.133 kPa)distention pressure,visceral sensitivity scores of visceral hypersensitivity rats and rats of control group were 1 .00±0.50 vs 1 .67 ±0.50,1 .89 ±0.31 vs 2.89 ±0.34 and 2.89 ±0.33 vs 3.89±0.33,the differences were statistically significant (t=-2.83,-6.00 and -6.00,all P <0.05 ). The results of master cells staining in tissue slides showed colonic master cells infiltration was obvious in rats with visceral hypersensitivity,and part of mast cells were degranulation.The result of ELISA demonstrated that NGF level of visceral hypersensitivity rats was significantly higher than that of control group ((11.07±3.06)pg/mg vs (2.38 ±1.88)pg/mg,t =-6.93,P <0.05).The results of electrophysilogical tests of primary cultured DRG indicated that compared with blank control growp,the action potential threshold of neuron in NGF 100 ng/mL group significantly decreased ((-18.0±2.1 )mV vs (-29.0 ± 2.5 )mV,t = 12.26,P <0.05)and discharge frequency increased ((5 .0± 1 .4 )/800 ms vs (12.0 ± 3.2)/800 ms,t=-8.40,P <0.05 ).Meanwhile,neuron voltage-gated K+ current density remarkably decreased,most were sustained delayed rectifier K+ current (I K )decreasing ((279.0 ±48.0)pA/pF vs (203.0±39.0)pA/pF,t=6.18,P <0.05).Conclusion Colonic stimulation in neonatal rats could cause intestinal master cells infiltration and degranulation,which induced changes of neuron electrophysilogical characters and resulted in visceral hypersensitivity after growing up.

12.
Rev. dor ; 13(3): 287-290, jul.-set. 2012.
Article in Portuguese | LILACS | ID: lil-650714

ABSTRACT

JUSTIFICATIVA E OBJETIVOS: As dores neuropáticas podem apresentar sinais inequívocos, mas, podem ser de difícil diagnóstico e o tratamento é difícil. O objetivo deste estudo foi relatar o caso de um paciente com dor crônica pós-traumática, com baixa adesão ao tratamento farmacológico e que foi tratado com bloqueios periféricos e adjuvantes. RELATO DO CASO: Paciente do gênero masculino, 42 anos, sofreu acidente automobilístico com trauma no quadril e na região lombar direita. Foi submetido à laparotomia exploradora com nefrectomia direita, osteossíntese de fêmur direito e de semilunar direito. Evoluiu com dor na região lombar direita que não melhorava com as medicações prescritas e com baixa adesão ao esquema terapêutico proposto, devido a sua difícil situação socioeconômica. Optou-se pelos bloqueios de nervos periféricos, em cinco sessões, realizados em regime ambulatorial. CONCLUSÃO: O tratamento com os bloqueios de nervos periféricos na região lombar foi eficaz e reduziu as sintomatologias da dor neuropática em até 60%, permanecendo com intensidade entre 3 e 4 pela escala analógica visual e ausência de dor ao toque da cicatriz.


BACKGROUND AND OBJECTIVES: Neuropathic pain may have earmarks, but may be difficult to diagnose and treat. This study aimed at reporting a case of post-traumatic chronic pain, with poor adherence to pharmacological treatment, which was treated with peripheral blocks and adjuvants. CASE REPORT: Male patient, 42 years old, who suffered a car accident with hip and right lumbar region trauma. Patient was submitted to laparotomy with right nephrectomy, right femur and right lunate osteosynthesis. Patient evolved with right lumbar region pain not improving with prescribed drugs and with poor adherence to proposed therapeutic approach due to his difficult socio-economic status. We decided for peripheral nerve blocks in five sessions, in outpatient regimen. CONCLUSION: Treatment with peripheral nerve blocks in the lumbar region was effective and has decreased neuropathic pain symptoms in up to 60%, remaining with intensity between 3 and 4 by the visual analog scale and with no pain when the scar was touched.


Subject(s)
Hyperesthesia , Lidocaine
13.
Rev. habanera cienc. méd ; 10(4): 540-544, oct.-dic. 2011.
Article in Spanish | LILACS | ID: lil-615842

ABSTRACT

Introducción: La Hiperestesia Dentinaria se define como «el dolor que surge de la dentina expuesta de forma característica, por reacción ante estímulos químicos, térmicos, táctiles u osmóticos, que no es posible explicar como surgido de otra forma o trastorno dental¼. Esta sensación dolorosa siempre es provocada y nunca espontánea. Existen diferentes métodos terapéuticos para su tratamiento; entre las tendencias actuales, podemos encontrar como parte de las terapias luminosas el Fototer 101-M, basado en el uso de radiación monocromática infrarroja para actuar como bioestimulante, antinflamatorio, analgésico y trófico. Objetivo: Para describir nuevas terapias alternativas efectivas que sean capaces de disminuir o eliminar esta sensación dolorosa, presentamos un caso clínico. Presentación del caso. Se trata de una paciente femenina de 27 años de edad, quien acude a consulta por presentar dolor en zona de los dientes 13 y 14, la cual fue diagnosticada con Hiperestesia Dentinaria y tratada bajo consentimiento informado con la terapia Fototer en sesiones continuas por un primer ciclo de 10 días, incidiendo el Led perpendicular al área afectada de forma puntual. Se descansó por un mes; se repiten solo seis sesiones nuevamente en el segundo ciclo, remitiendo el síntoma dolor desde la quinta sesión del primer ciclo. Conclusiones: No se observaron reacciones adversas durante el tratamiento y se recomienda la terapia Fototer-101 como otra alternativa posible de tratamiento para la Hiperestesia Dentinaria.


Introductio: Dentine hyperesthesia is defined as a pain that arises from the exposed dentine by a peculiar way of reaction to chemical, thermal, tactile or osmotic stimulus. This type of pain is always caused and it is never spontaneous. There exists different therapeutic methods for its treatment. As part of the luminous therapies we can find Fototer 101-M which is based on infrared monochromatic radiation that acts as analgesic and anti-inflammatory agent. Objective: We are presenting a case report with the objective of finding new alternative effective therapies that might be able to eliminate or diminish this painful sensation. Case presentation She is a 27 years old patient who comes for consultation complaining of pain in zone 13 and 14 and she was diagnosed of Dentine hyperesthesia. She was applied with the mentioned therapy in repeated sessions for a 10 days cycle impacting the affected area with perpendicular light emitting diode (LED). After resting for 1 month 8 more sessions were repeated in a 2nd cycle remitting pain after the fifth session of the first cycle. Conclusion: There were not adverse reactions during the treatment.

14.
Braz. dent. j ; 22(2): 157-161, 2011. tab
Article in English | LILACS | ID: lil-583806

ABSTRACT

The aim of this study was to evaluate the efficacy of two desensitizing agents in the reduction of dentin hypersensitivity in a randomized, double-blind, split-mouth clinical trial. Seventy-seven teeth from 13 patients that presented some degree of sensitivity to probing and/or air stimulation were treated with one of the following desensitizing agents: Oxa-Gel (G1), Sensi Kill (G2) and placebo gel (G3 - control). According to paired t-test, all treatments, even the placebo gel, were capable of reducing sensitivity scores for both stimuli. Analysis of data by ANOVA and Tukey's test (?=0.05) showed that the sensitivity scores were significantly lower only for Sensi Kill in comparison to the other products (Oxa-Gel and placebo), when air stimulus was applied. It may be concluded that treatment with Sensi Kill presented a slightly better performance in reducing dentin hypersensitivity when compared to the other desensitizing agent.


O objetivo desse estudo foi avaliar a eficiência de dois agentes dessensibilizantes na redução da hipersensibilidade dentinária, em um estudo clínico aleatório do tipo boca-dividida e duplo-cego. Setenta e sete dentes de 13 pacientes que apresentavam algum grau de sensibilidade à sondagem e/ou estímulo ao ar foram tratados com um dos seguintes agentes dessensibilizantes: Oxa-Gel (G1), Sensi Kill (G2) e gel placebo (G3-controle). De acordo com o teste t pareado, todos os tratamentos, inclusive o placebo, foram capazes de reduzir os escores para ambos os estímulos. A análise dos dados pelos testes de ANOVA e de Tukey (?=0,05) demonstrou que os escores de sensibilidade foram significantemente menores somente para o Sensi-Kill em comparação aos outros produtos (Oxa-Gel e placebo) quando o estímulo ar foi aplicado. Pode-se concluir que o tratamento com Sensi-Kill apresentou um desempenho ligeiramente melhor na redução da hipersensibilidade dentinária quando comparados aos outros agentes dessensibilizantes.


Subject(s)
Adult , Female , Humans , Male , Dentin Desensitizing Agents/therapeutic use , Dentin Sensitivity/drug therapy , Analysis of Variance , Double-Blind Method , Pain Measurement , Placebo Effect , Statistics, Nonparametric , Treatment Outcome
15.
Rev. méd. Minas Gerais ; 19(4,supl.3): S103-S106, out.-dez. 2009. ilus
Article in Portuguese | LILACS | ID: lil-568883

ABSTRACT

Causalgia é um tipo de doença neurológica crônica pertencente à Síndrome Dolorosa Regional Complexa, normalmente associada ao trauma. A sintomatologia é caracterizada por dor espontânea em queimação, hiperalgesia, edema, instabilidade vasomotora, alteração da função motora e anormalidades autonômicas. É rara, pouco conhecida e envolve várias teorias acerca de sua fisiopatologia. São descritas neste trabalho as manifestações de paciente masculino, de 20 anos, atendido no Pronto Socorro do Hospital Risoleta Tolentino Neves, vítima de múltiplas lesões por projéteis de arma de fogo, que evoluiu com manifestações compatíveis com causalgia.


Causalgia is a kind of chronic neurological disorder which is part of the Complex Regional Pain Syndrome, usually associated to trauma. Its symptoms are severe burning pain, hyperalgesia, edema, abnormal vasomotor activity, impairment of motor function and autonomic dysfunction. It is a rare, poorly known disease, which involves various theories in regard to its physiopathology. We report, in this article, a clinical case of a 20-year-old male patient, who was treated in the Emergency Room of Risoleta Tolentino Neves Hospital, victim of multiple lesions by firearm projectiles and evolved with symptoms compatible to the clinical features of Causalgia.


Subject(s)
Humans , Male , Adult , Causalgia , Wounds, Gunshot/diagnosis , Hyperesthesia , Tomography, Emission-Computed
16.
Journal of the Korean Society of Plastic and Reconstructive Surgeons ; : 46-50, 2009.
Article in Korean | WPRIM | ID: wpr-29241

ABSTRACT

PURPOSE: Finger injury by green onion cutting machine is one of the common hand injuries in the kitchen. It has a unique feature: there are multiple parellel laceration 3 -5mm wide. There are two directions of injuries(vertical, oblique). It may involve bone, tendon, nerve, and vessel injuries. We discuss its management and the long -term progress. METHODS: We have treated six patients from 2003 to 2007. We carried out low tension approximation with thin suture materials to avoid ischemia and performed the additional operation as nail bed repair, tenorrhaphy, open reduction, vessel anastomosis, and composite graft. We reviewed the record of initial injury and collected the follow-up record. RESULTS: They were all middle aged - women who had worked in the kitchen. Right hand was dominent over left hand. The ratio of the directions was 3:3 (vertical:oblique). They were all competely healed although there were three atrophy, four hyperesthesia, and one nail deformity. CONCLUSION: Finger injury by green onion cutting machine is a unique pattern of laceration with various accompanied injuries. It may look like a severe form of injury, but in most cases have relatively favorable progress. We have to perform careful examination of accompanied injuries and carry out the proper management. First and foremost, the user especially in the middle aged women should be warned to be careful in handling this risky machine.


Subject(s)
Female , Humans , Middle Aged , Atrophy , Finger Injuries , Fingers , Follow-Up Studies , Glycosaminoglycans , Hand , Hand Injuries , Handling, Psychological , Hyperesthesia , Ischemia , Lacerations , Nails , Onions , Sutures , Tendons , Transplants
17.
Arch. méd. Camaguey ; 11(5): 0-0, sep.-oct. 2007.
Article in Spanish | LILACS | ID: lil-731922

ABSTRACT

Se realizó un ensayo clínico fase II temprana y abierto en la Clínica Estomatológica de Adultos de Florida desde octubre de 2004 hasta agosto de 2005 con una muestra de 60 pacientes para evaluar la eficacia de la tintura de propóleo al 20 % en el tratamiento de la hiperestesia dentinaria, clasificar la hiperestesia según los síntomas, precisar la remisión de los síntomas a las 24, 48 y 72 horas de iniciado el tratamiento y determinar las posibles reacciones adversas. El tratamiento fue ambulatorio, se aplicó propóleo al 20 % de forma tópica en los dientes afectados, tres aplicaciones con una frecuencia diaria y se evaluó la eficacia a los 72 h. En este estudio fue más frecuente la hiperestesia leve seguida de la moderada. El propóleo al 20 % fue una terapia eficaz cuando se presentaron hiperestesias leves y moderadas. Se observó remisión de los síntomas de forma significativa a partir de las 48h, sin embargo, en la hiperestesia severa la probabilidad de eliminar el dolor a las 72h fue del 50 %. No se reportaron reacciones adversas en este estudio.


An early and open clinical trial phase II at the Adult Odontology Clinic of Florida from October 2004 to August 2005 was conducted, with a sample of 60 patients to assess the effectiveness of the tincture of propoleo at 20% in the treatment of dentinal hyperesthesia, to classify the hyperesthesia according to the symptoms, to specify the remission of the symptoms at 24, 48 and 72 hours after initiated the treatment and to determine the possible adverse reactions. The treatment was ambulatory, it was applied propoleo at 20% of topical form in the affected teeth, three applications with a daily frequency and the effectiveness was assessed at the 72 h. In this study was more frequent mild hyperesthesia followed by moderate. The propoleo at 20 % was an efficient therapy when it were presented mild and moderate hyperesthesias. Remission of the symptoms in a significant way departing from the 48h it was observed; nevertheless, in severe hyperesthesia the probability to eliminate the pain at 72h was about the 50%. No adverse reactions in this investigation were reported.

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