ABSTRACT
Two new type B polycyclic polyprenylated acylphloroglucinols (PPAPs) (1 and 2) and a known biogenetic precursor hyperbeanol Q (3) were isolated from the root extract of Hypericum beanii, a medicinal plant widespread in southwest China. Their chemical structures were elucidated by 1D/2D NMR and HRESIMS data analysis, and absolute configurations were determined through detailed electric circular dichroism (ECD) analysis including ECD exciton chirality, Mo
ABSTRACT
Objective: To study the chemical constituents from the aerial parts of Hypericum beanii. Methods: Various chromatographic techniques were used to separate the constituents and their structures were elucidated on the basis of extensive spectroscopic interpretation. Results: Fifteen compounds were isolated from the aerial parts of H. beanii. Their structures were identified as hyperbeanol E (. 1), (E)-linalool-1-oic acid (. 2), (4S,5R)-5-(4'-methyl-3'-pentenyl)-4-hydroxy-5-methyl-dihydrofuran-2-one (. 3), benzoic acid (. 4), 4-(3-O-3')-3'-methylbutenyl-6-phenyl-pyran-2-one (. 5), 4-hydroxy-4a,7-dimethoxy-4,4a-dihydrodibenzo-p-dioxin-2(3H)-one (. 6), isoimperatorin (. 7), 2,3-dimethoxyxanthone (. 8), 3,4-dihydroxy-2-methoxyxanthone (. 9), osajaxanthone (. 10), nigrolineaxanthone F (. 11), hypercohone G (. 12), betulinic acid (. 13), oleanolic acid 3β-caffeate (. 14), and isoastilbin (. 15). Conclusion: Compound 1 is a new menthane monoterpene derivative which owns an extra lactone ring. Compounds 2-7 and 10-15 are isolated from genus Hypericum Linn. for the first time and the other compounds are first obtained from the plants in H. beanii.