Curative efficacy of different doses of atorvastatin combined with fenofibrate in treatment of mixed type and its effects on blood lipid and prognosis / 中国基层医药

Objective To study the curative efficacy of different doses of atorvastatin combined with fenofibrate in treatment of mixed type hyperlipidemia and its effects on blood lipid and prognosis.Methods 120 patients of mixed type hyperlipidemia who received therapy were selected as research subjects.According to random number table,the patients were divided into A group (n=60) and B group (n=60).The two groups were treated with atorvastatin and fenofibrate,the dose of atorvastatin in A group was 10mg,which in B group was 20mg,fenofibrate dose was 200mg.After 4 weeks of treatment,the therapeutic effect was compared.Results After treatment,the blood lipids of the two groups were improved(P0.05).The incidence rate of adverse reactions in A group was lower than that in B group[96.67%(58/60) vs.76.67%(46/60)](x2=6.171,P<0.05).Conclusion Low dose (10 mg) of atorvastatin combined with fenofibrate for mixed type hyperlipidemia has good lipid regulating effect,and adverse reaction is low,has little effect on the liver function of patients,which can effectively improve the prognosis,it is worthy of application and promotion.

Analysis of interal carotid artery hemodynamics of patients with hyperlipemia by transcranial doppler ultrasound(TCD) / 中国基层医药

Objective To explore the clinical application value of transcranial Doppler on patients with hyperlipidemia. Methods 80 patients with hyperlipemia and 70 healthy people were studied by transcranial Doppler ultrasound(TCD) of interal carotid artery hemodynamics. Results 57 (71.7%)of the 80 patients with hyperlipemia had arteriosclerosis, and terminal sclerosis happened on 12 patients ( 13.3% ). Compared with the control group, the difference was all statistically significant ( P ＜ 0.05 ). Conclusion Hemodynamics at the terminal of interal carotid artery patients with hyperlipemia was obvious abnormal studied by transcranial Doppler ultrasound (TCD) , and sclerosis of interal carotid artery is common complication of patients with hyperlipemia. Results showed that TCD could be used as a routine method for testing of patients with hyperlipemia and had some value in preventing cerebrovascular disease induced by hyperlipidemia.