Chemical constituents from Hypericum monogynum / 中草药

Objective: To study the chemical constituents of Hypericum monogynum. Methods: The chemical constituents were isolated and purified by solvent extraction method, the normal and reverse phase silica gel column chromatography and semi-preparative high performance liquid chromatography. Results: Six compounds were isolated from the chloroform extract of H. monogynum. Their structures were identified as hypermongone A (1), β-sitosterol (2), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (3), isocudraniaxanthone B (4), betulinic acid (5), and 2-hydroxydiplopterol (6) by the physicochemical properties and modern spectroscopic methods. Conclusion: Compound 1 is a new compound, and compounds 3, 4, and 6 are isolated from H. monogynum for the first time.