The role of Kisspeptin in sexual development / 国际儿科学杂志

Activation of gonadotrophic hormone neuronstion and downstream reproductive hormones (luteinizing hormone and follicle stimulating hormone) secretion is the key event representing the onset of puberty.Hypothalamic pituitary gonad axis varies among gender,season and the stage of development.A number of hormones are involved in the control of hypothalamic pituitary gonad axis.Kisspeptins are potent secretagogues for gonadotrophic hormone,and the KISS1 gene is a target for regulation by gonadal steroids,metabolic factors,photoperiod,and season.This review focuses on Kisspeptin in the regulation of sexual development.