Modelación espacial bayesiana de la estructura de los hogares y la fecundidad en municipios de México

El trabajo busca modelar el efecto de diferentes patrones de composición de hogares sobre los niveles observados de fecundidad en los municipios de México al año 2020, se trata de una investigación de tipo cuantitativo de cohorte transversal basada en la aplicación de métodos bayesianos espaciales. La hipótesis sostiene que la presencia de un mayor porcentaje de hogares familiares debería impactar en mayores tasas de fecundidad municipales. La metodología comprende la implementación de dos modelos gaussianos latentes. Un modelo nulo busca determinar si los patrones observados de fecundidad se asocian a algún mecanismo sociodemográfico o, al contrario, surgieron aleatoriamente, y otro modelo con covariables, cuyo objetivo es replicar el comportamiento de la fecundidad evaluando las consecuencias de la proporción de hogares nucleares, ampliados y compuestos presentes en los municipios. Los resultados obtenidos a partir de la estimación del modelo nulo confirmaron la existencia de una relación directa entre el aumento del índice de hogares nucleares y ampliados y el de la fecundidad municipal. Sin embargo, se puede concluir que el nivel alcanzado de fecundidad de reemplazo es producto de marcadas diferencias entre municipios, originadas por la presencia de una tipología heterogénea de hogares inmersos en contextos geográficos, sociales y culturales dispares.

This paper seeks to model the effect that different patterns of household composition have on the observed levels of fertility in the municipalities of Mexico in the year 2020; it is a quantitative cross-sectional cohort research based on the application of spatial Bayesian methods. The hypothesis is that the presence of a higher percentage of family households should have an impact on higher municipal fertility rates. The methodology involves the implementation of two latent Gaussian models. One null model, which seeks to determine whether the observed fertility patterns were generated by some socio-demographic mechanism or, on the contrary, arose randomly, and two, a model with covariates whose objective is to replicate the behavior of fertility by evaluating the effect of the proportion of nuclear, extended and compound households present in municipalities. The results obtained from estimation of null model confirm the existence of a direct relationship between increase in the proportion of nuclear and extended households and the increase of municipal fertility. However, it can be concluded that the level of replacement fertility reached by Mexico in the year 2020 is the product of marked differences between municipalities; differences originated by the presence of a heterogeneous typology of households immersed in disparate geographic, social and cultural contexts.

Total antibiotic use in a state-wide area and resistance patterns in Brazilian hospitals: an ecologic study

ABSTRACT Introduction: Use of antibiotic and bacterial resistance is the result of a complex interaction not completely understood. Objectives: To evaluate the impact of entire antimicrobial use (community plus hospitals) on the incidence of bloodstream infections in intensive care units adjusted by socioeconomic factors, quality of healthcare, and access to the healthcare system. Design: Ecologic study using a hierarchical spatial model. Setting: Data obtained from 309 hospitals located in the state of São Paulo, Brazil from 2008 to 2011. Participants: Intensive care units located at participant hospitals. Outcome: Hospital acquired bloodstream infection caused by MDRO in ICU patients was our primary outcome and data were retrieved from São Paulo Health State Department. Socioeconomic and healthcare indexes data were obtained from IBGE (Brazilian Foundation in charge of national decennial census) and SEADE (São Paulo Planning and Development Department). Information on antimicrobial sales were obtained from IMS Brazil. We divided antibiotics into four different groups (1-4). Results: We observed a direct association between the use of group 1 of antibiotics and the incidences of bloodstream infections caused by MRSA (1.12; 1.04-1.20), and CR-Acinetobacter sp. (1.19; 1.10-1.29). Groups 2 and 4 were directly associated to VRE (1.72; 1.13-2.39 and 2.22; 1.62-2.98, respectively). Group 2 was inversely associated to MRSA (0.87; 0.78-0.96) and CR-Acinetobacter sp. (0.79; 0.62-0.97). Group 3 was inversely associated to Pseudomonas aeruginosa (0.69; 0.45-0.98), MRSA (0.85; 0.72-0.97) and VRE (0.48; 0.21-0.84). No association was observed for third generation cephalosporin-resistant Klebsiella pneumoniae and Escherichia coli. Conclusions: The association between entire antibiotic use and resistance in ICU was poor and not consistent for all combinations of antimicrobial groups and pathogens even after adjusted by socioeconomic indexes. Selective pressure exerted at the community level seemed not to affect the incidences of MDRO infection observed in intensive care setting.

Modelación espacial bayesiana del riesgo de embarazo adolescente a través de la aproximación anidada integrada de Laplace en Chiapas, 2015 / Bayesian spatial modeling of adolescent pregnancy risk through integrated nested Laplace approximation in Chiapas, 2015

Resumen El objetivo del trabajo es analizar la distribución espacial de la fecundidad adolescente municipal en Chiapas durante 2015. Método: a partir de la utilización de modelos aditivos estructurales estimados mediante la aproximación anidada integrada de Laplace. Resultados: Un primer modelo identifica los patrones espaciales no aleatorios de la fecundidad, mientras un segundo modelo analiza el efecto que ejercen cofactores como: pobreza, marginación y analfabetismo, sobre la distribución espacial de la fecundidad adolescente. Discusión: Los resultados parecen confirmar que los espacios donde se registran mayores índices de marginación, analfabetismo y pobreza incrementan el riesgo de configurar un clúster donde las tasas de fecundidad adolescente observadas son en promedio mayores que las presentadas por los municipios vecinos.

Abstract The objective of the study is to analyze the spatial distribution of adolescent municipal fertility in Chiapas during 2015. Method: from the use of estimated structural additive models through the integrated nested approach of Laplace. Results: A first model identifies the non-random spatial patterns of fertility, while a second model analyzes the effect of cofactors such as poverty, marginalization and illiteracy on the spatial distribution of adolescent fertility. Discussion: The results seem to confirm that the spaces where higher rates of marginalization, illiteracy and poverty are registered increase the risk of setting up a cluster where the adolescent fertility rates observed are on average higher than those presented by neighboring municipalities.

Análise espacial dos determinantes sociais e o risco de mortes por tuberculose da aplicação da estatística de varredura à abordagem Bayesiana em uma metrópole do Centro Oeste brasileiro / Spatial analysis of social determinants and risk of death from tuberculosis: from the application of scanning statistics to the Bayesian approach in the brazilian Midwest

A tuberculose é uma das dez principais causas de morte dentre as doenças infecciosas no mundo, o que evidencia a doença como um problema de saúde pública. A redução da mortalidade por tuberculose em 95% até 2035, proposta pela Estratégia End TB, tem sido desafiadora para o Brasil devido sua extensão territorial, variações culturais e desigualdades na distribuição dos recursos de proteção social e de saúde. Assim, buscou-se analisar a relação espacial e espaço-temporal dos determinantes sociais e o risco de mortes por tuberculose em Cuiabá. Trata-se de um estudo ecológico, realizado na cidade de Cuiabá, capital do estado de Mato Grosso. As unidades de análise do estudo foram as Unidades de Desenvolvimento Humano (UDHs) e a população foi constituída por casos de óbitos que apresentaram como causa básica a TB registrados no Sistema de Informação sobre Mortalidade (SIM) entre 2006 a 2016, residentes na zona urbana do município. Para identificação das áreas de risco das mortes por tuberculose, utilizou-se a estatística de varredura. Em seguida, recorreu-se à técnica da Análise de Componentes Principais que permitiu a elaboração das dimensões dos determinantes sociais. A associação entre os determinantes sociais e as áreas de risco das mortes por tuberculose foi obtida, por meio da regressão logística binária. As modelagens Bayesianas foram empregadas, por meio da abordagem Integrated Nested Laplace Approximation (INLA), para verificar os riscos relativos temporais e espaciais e avaliar sua a relação com covariáveis representativas dos determinantes sociais. Nesse período foram registradas 225 mortes por tuberculose, identificou-se aglomerado de risco para a mortalidade por tuberculose, com RR = 2,09 (IC95% = 1,48-2,94; p = 0,04). No modelo logístico, os determinantes sociais relacionados ao déficit escolar e pobreza estiveram associados ao aglomerado de risco de mortes por tuberculose (OR=2,92; IC95% = 1,17-7,28), a renda apresentou uma associação negativa (OR=0,05; IC95% = 0,00 - 0,70). O valor da curva ROC do modelo foi de 92,1%. Em relação aos modelos Bayesianos observou-se redução do risco de morte por tuberculose entre 2006 (RR=1,03) e 2016 (RR=0,98) e ainda áreas de risco que persistem por mais de uma década. Dentre os determinantes sociais, a renda foi um importante fator associado ao risco de morte por tuberculose, sendo que o aumento de um desvio padrão na renda correspondeu à diminuição de 31% no risco de mortalidade por tuberculose. Os resultados do estudo apontam que existe associação entre os determinantes sociais e o risco de mortalidade por tuberculose no município investigado, sendo este um fenômeno que persiste no tempo. O investimento em políticas públicas de melhoria de distribuição de renda pode favorecer a mudança dessa realidade. Espera-se que os achados possam nortear gestores e trabalhadores no âmbito local e regional

Tuberculosis is one of the top 10 causes of death among infectious diseases in the world, which shows the disease as a public health problem. The reduction of tuberculosis mortality by 95% up to 2035, proposed by the End TB Strategy, has been challenging for Brazil due to its territorial extension, cultural variations and inequalities in the distribution of social protection and health resources. Thus, we sought to analyze the spatial and spatial-temporal relationship of social determinants and the risk of deaths from tuberculosis in Cuiabá.This is an ecological study conducted in the city of Cuiaba, capital of Mato Grosso. The units of analysis of the study were the Human Development Units (UDHs) and the population was constituted by cases of deaths that presented the basic cause of TB registered in the Mortality Information System (SIM) between 2006 and 2016, of the municipality.To identify the risk areas for tuberculosis deaths, the scan statistic was used. Next, we used the technique of Principal Component Analysis that allowed the elaboration of the dimensions of social determinants. The association between social determinants and risk areas for tuberculosis deaths was obtained through binary logistic regression. Bayesian modeling was used, through the Integrated Nested Laplace Approximation (INLA) approach, to verify temporal and spatial relative risks and to evaluate its relationship with covariables representative of social determinants. During this period, there were 225 deaths due to tuberculosis and a risk cluster was identified for tuberculosis mortality, with RR = 2.09 (IC95% = 1.48-2.94, p = 0.04). In the logistic model, the social determinants related to school deficit and poverty were associated with the risk cluster of deaths due to tuberculosis (OR = 2.92, IC95% = 1.17-7.28), income had a negative association (OR = 0.05, IC95% = 0.00 - 0.70). The value of the ROC curve of the model was 92.1%. In relation to Bayesian models, there was a reduction in the risk of death due to tuberculosis between 2006 (RR = 1.03) and 2016 (RR = 0.98), as well as risk areas that persisted for more than a decade. Among the social determinants, income was an important factor associated with the risk of death due to tuberculosis, and the increase of a standard deviation in the income corresponded to a 31% decrease in the risk of mortality due to tuberculosis. The results of the study indicate that there is an association between the social determinants and the risk of mortality due to tuberculosis in the municipality under investigation, which is a phenomenon that persists over time. Investment in public policies to improve income distribution may favor a change in this reality. It is hoped that the findings will guide managers and workers at local and regional levels