ABSTRACT
The function of hypothalamic-pituitary-ovarian axis and the size of uterus and ovary were determined in 57 girls with idiopathic true precocious puberty at various stages of pubertal development. The results showed: 1) The extent of precocious puberty correlated closely with the course of the disease, the degree of bone growth accelaration, the size of uterus and ovary, and the hyperfunctional state of the hypothalamic-pituitary-ovarian axis, however irrelevant to the age at onset of the disease; 2) The hypothalamic-pituitary-ovarian axis in girls with idiopathic precocious puberty started beforehand and was in a state of hyperfunction. There were characteristic changes in their reactive curve in response to LHRH-stimulating test; 3) In comparison with normal pubertal development, the development of internal genitalia in the girls with idiopathic precocious puberty was more immature and the size was relatively smaller.