ABSTRACT
Background: Japanese Encephalitis is one of the mostimportant causes of viral encephalitis worldwide, with anestimated 50,000 cases and 15,000 deaths annually. Thepresent study was undertaken to investigate theSeroprevalence and Seasonal Trend of Japanese Encephalitisin Jamshedpur.Methods: It was a hospital-based retrospective studyconducted from August 2011 to December 2017. A total of 571consecutive non-repetitive patients, satisfying the clinical casedefinition of JE as per the WHO guidelines, were included inthe study. Cerebrospinal fluid (CSF) and serum samples weretested for JEV-specific IgM antibodies by the NIV JE IgMCapture ELISA Kit.Results: Out of which 166/571 (29.07%) were JE positivediagnosed by IgM Mac ELISA antibody kit. We have observedthat in a period of six years, the JE positivity rate hassignificantly reduced from 39.84% in 2011 to 7.29% in 2017.Conclusions: A declining trend of JE was seen in this study,however further research work needs to be done to lookfor non-JE causes of JE. Surveillance & effective vaccinationshould be carried out regularly for early detection of animpending outbreak and to initiate timely preventive and controlmeasures.
ABSTRACT
Background: The present study was undertaken to investigate the trend of JE and the different parameters associated with it.Methods: It was a hospital-based retrospective study conducted from January 2014 to December 2017. A total of 3531 consecutive non-repetitive patients, satisfying the clinical case definition of AES as per the WHO guidelines, were included in the study. Cerebrospinal fluid (CSF) and serum samples were tested for JEV-specific IgM antibodies by the NIV JE IgM Capture ELISA Kit.Results: Of the 3531 patients admitted, 838(23.7%) cases were positive for JE IgM antibodies. There was a significant reduction in the JE positivity rate from 32.9% in 2014 to 13.3% in 2017. The male-to-female ratio was 1.6:1. JE positivity rate was significantly higher in adults as compared to children. The majority of cases occurred during the monsoon and post-monsoon season. Fever (100%), change in mental status (87.8%), headache (70.5%), neck rigidity (32.4%), unconsciousness (35.4%), seizure (43.9%) and paralysis (5%) were the major clinical symptoms. JE positivity was seen to be higher in the rural areas of Assam.Conclusions: A declining trend of JE was seen in this study, however further research work needs to be done to look for non-JE causes of AES.
ABSTRACT
Background: Dengue fever and Dengue Haemorrhagic feveris an acute viral disease caused by Dengue virus. The infectionis transmitted by female mosquito- Aedes aegypti. The presentstudy was undertaken to investigate the trend of Dengue andthe seasonal effect associated with it. During late August 2010,outbreak of dengue symptomatic patients was admitted toMGM Medical college hospital Jamshedpur. ELISA for antidengue antibodies confirmed the case as Dengue.Objective: This retrospective study was done to analyze thecirculating dengue virus seroprevalence and seasonal trendamong the patients of the disease who attended to MGMMedical College, Jamshedpur, A tertiary care hospital during2010 to 2015.Methods: It was a hospital-based retrospective studyconducted from September 2010 to December 2015. A total of342 consecutive non-repetitive patients, satisfying the clinicalcase definition of Dengue as per the WHO guidelines, wereincluded in the study. Serum samples were tested for Denguespecific IgM antibodies by NIV Dengue IgM Capture ELISA Kit.Results: Of the 342 patients attended, 110(32.16%) caseswere positive for Dengue IgM antibodies. There was asignificant reduction in the Dengue positivity rate from 31% in2010 to no cases in 2015. The majority of cases occurredduring the monsoon and post-monsoon season.Conclusions: A declining trend of Dengue was seen in thisstudy, however further research work needs to be done to lookfor non-Dengue causes of Dengue fever. Surveillance shouldbe carried out regularly for early detection of an impendingoutbreak and to initiate timely preventive and controlmeasures.