ABSTRACT
Objective To analys the clinicopathological features and pathological diagnosis and differential diagnosis of the nasal neuroendocrine carcinomas (NEC). Methods 12 cases of nasal neuroendo crine carcinomas were studied with clinical datas and light microscopic examination and electron microscopic and immunohistchemical staining. Results The majority of the patients were middleaged. The patient population was composed of 10 meles and 2 females(sex ratio,5:1) with average age 39 6 years. On pathological examination,8 of them were small cell type neuroendocrine carcinoma,3 large cell type neuroendocrine carcinoma and 1 atypical ueuroendocrine carcinoma. Electron microscopy of 8 cases showed abundant neuroendocrine granules in the tumors. Immunohistochemical analysis showed that cells expressed EMA,CK,CgA,NSE and Syn Conclusions The key point for clinicopathological features of the NEC were discussed. Its differentila diagnosis includes malignant lymphoma, undifferentiatel carcinoma, malignant melanoma and olfactory neuroblastoma. Histological type of the tumor is important for clinical treatment plan and prognostic evaluation