ABSTRACT
Objective To investigated the changes of plasma NT-proBNP levels in patients with acute myocardial infarction(AMI),unstable angina pectoris(UAP)and non-insulin-dependent diabetes(NIDD).Methods Plasma NT-proBNP levels were determined with RIA in 32 patients with AMI,27 patients with UAP,12 patients with NIDD and 20 controls.Moreover,16 of the 32 AMI patients underwent precutancous transluminal coronary angioplasty(PTCA)and plasma NT-proBNP levels were again determined 12h before and 12h after the procedure.Results The plasma NT-proBNP levels in controls were(360.8±57.3)pg/ml with no significant difference between the sexes.In patients with AMI,UAP and NIDD,NT-proBNP levels were(554.1±195 9)pg/ml,(525.7±199.1)pg/ml and(552.6±141.9)pg/ml respectively;all of them were significantly higher than those in controls.AMI patients increased from(563.1±190.1)pg/ml to(774.7±238.9)pg/ml(P＜0.05).12 hours after PTCA.However,NT-proBNP levels did not differ statistically among AMI,UAP and NIDD patients(P＞0.05).Conclusion The plasma NT-proBNP levels in patients with AMI,UAP and NIDD were increased significantly and the result suggested that NT-proBNP might beauseful risk marker for these diseases.