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Background: In hypertensive patients with impaired fasting glycaemia (IFG), the incidence of Type 2 diabetes mellitus is 20%, which further worsens the situation. Currently, no approved drug is available for the treatment of IFG. Telmisartan has partial agonistic activity at the PPAR? receptor, thereby reducing insulin resistance. Hence, this study was undertaken. Aim and Objectives: Primary objective: To evaluate the effect of telmisartan on glycosylated haemoglobin (HbA1c) and fasting plasma glucose (FPG) levels. Secondary objective: To evaluate the effect of telmisartan on Body Mass Index (BMI). Materials and Methods: In this prospective observational study, 100 newly diagnosed cases of hypertension with IFG were included. Before the treatment with telmisartan, baseline parameters such as Glycosylated haemoglobin (HbA1c), FPG, BMI, and blood pressure (BP) were recorded. Then, follow-up was done at 4, 8, and 12 weeks. BP and FPG were repeated at 4 and 8 weeks, whereas at 12 weeks all the four parameters were repeated. All the study endpoints were analyzed using paired t-test. Results: In this study, telmisartan reduced mean HbA1c from 5.87 ± 0.09 to 5.66 ± 0.17%, FPG levels from 111.49 ± 3.82 to 104.28 ± 4.60 mg/dl, BMI from 24.20 ± 1.84 to 23.80 ± 1.75 kg/m2 and SBP from 148.44 ± 3.64 to 133.43 ± 3.00, DBP from 91.90 ± 2.37 to 82.08 ± 2.45 mm of Hg at the end of 12 weeks of treatment (P < 0.001). There were no serious adverse effects observed during the study period. Conclusion: In this study, telmisartan reduced HbA1c, FPG, BMI, and BP values significantly. Hence, telmisartan is safe and has a significant effect on the reduction of both BP and insulin resistance.
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To examine the risk factors for developing diabetes on its 3-year outcome in an elderly population with impaired fasting glucose ( IFG) . We selected the 328 elderly with impaired fasting glucose in Binhai new area of Tianjin as the research object. All subjects participated in objective examinations such as physical activity ability tests, blood tests and anthropometric examinations, and completed the questionnaire survey. Between baseline and 3-year outcome, 56 of the subjects with IFG at baseline have developed diabetes. After multivariate adjustments, we found that higher incidence of diabetes was associated with higher fasting plasma glucose (OR=9.30, 95％CI 2.84-30.48, P<0.01) and reduced grip strength/weight ( OR=0.88, 95％CI 0.82-0.94, P<0.01) . Moreover, the combination of higher fasting plasma glucose and lower grip strength/weight would lead to higher incidence of diabetes compared with higher fasting plasma glucose or lower grip strength/weight alone ( P<0.05) . In this study, high fasting plasma glucose and low muscle strength were associated with blood glucose worsening in three years in IFG patients. In addition to blood glucose levels, physical activity is also a risk factor for diabetes in older adults.
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To examine the risk factors for developing diabetes on its 3-year outcome in an elderly population with impaired fasting glucose (IFG). We selected the 328 elderly with impaired fasting glucose in Binhai new area of Tianjin as the research object. All subjects participated in objective examinations such as physical activity ability tests, blood tests and anthropometric examinations, and completed the questionnaire survey. Between baseline and 3-year outcome, 56 of the subjects with IFG at baseline have developed diabetes. After multivariate adjustments, we found that higher incidence of diabetes was associated with higher fasting plasma glucose (OR=9.30, 95%CI 2.84-30.48, P<0.01) and reduced grip strength/weight (OR=0.88, 95%CI 0.82-0.94, P<0.01). Moreover, the combination of higher fasting plasma glucose and lower grip strength/weight would lead to higher incidence of diabetes compared with higher fasting plasma glucose or lower grip strength/weight alone (P<0.05). In this study, high fasting plasma glucose and low muscle strength were associated with blood glucose worsening in three years in IFG patients. In addition to blood glucose levels, physical activity is also a risk factor for diabetes in older adults.
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Objective To investigate the impact of age on patients with metabolic syndrome (MS) and normal persons. Methods Data was gathered from 8280 persons including 4873 males and 3407 females who were randomly selected. All subjects were devided into normal group and MS group. According to the interval of ten years, the subjects were devided into seven age groups, to calculate the difference of impaired fasting glycaemia (IFG) between patients with diabetes mellitus (DM) and normal people, as well as the related portions. Results (1) The risk of IFG and DM appeared to be different among age groups among the target subjects as well as in the normal and the MS groups (P<0.05). (2) Among the whole subjects, the overall prevalence of IFG was increasing with age. The prevalence of DM had an increasing trend with age augment in 20-79 years group, whereas a decreasing trend appeared in people over 80 years of age. (3) For normal persons, the prevalence of IFG and DM were all increasing with age augment in 20-79 years group, and then decreasing with age augment in the over-80-years group. (4)For MS patients, the prevalence of IFG had an increasing trend with age augment in 20-69 years group, whereas a decreasing trend appeared in people over 70 years of age. There was no tendency of variation with age augment in DM.Conclusions (1) For normal persons, high prevalence rates of IFG and DM were correlated to age augment, especially in senior persons. (2) For MS patients, high prevalence of IFG was also correlated to age augment, but no association between prevalence of DM and age augment was seen. (3)Age from 70 to 79 years appeared to be in high risk with MS.
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Objective To investigate the current status of impaired fasting glycaemia (IFG),diabetes mellitus(DM) and correlated factors, as well as on the awareness, treatment and control rate of diabetes mellitus in rural residents of Lanxi, Heilongjiang. Methods Cross-sectional and cluster sampling method was carried out on 3480 residents over 35 years of age, in rural residents of Lanxi Pingshan,Heilongjiang province. Results To male, female and all, the detecting rate of IFG were 5.06%,4.38% and 4.68% respectively, and the standardization rate of IFG became 4.71%, 4.24% and 4.47% respectively. The prevalence rates of DM were 7.85%, 6.57% and 7.15% but after standardization, they became 7.22%, 6.62% and 6.80% respectively. Results did not show statistical difference between sex and the level of fasting glycaemia (χ2 = 2. 725, P = 0. 256). The prevalence rates of IFG and DM increased with age and difference was seen between age and fasting glycaemia level (χ2 = 58.115, P = 0. 000). Data from multivariable stepwise analysis showed that age, smoking, BMI and high triglyceride were the significant factors in fasting glycaemia level, and the ORs (95% CI) were 1. 518 ( 1. 360-1. 694), 1. 277(1.134-1.439),1.187(1.014-1.391) and 1.754(1.385-2.220) respectively. The rates of awareness,treatment and control rate in DM were 12.74%, 9.43% and 4.72% respectively while the treatment rate among those who knew the disease was 74.07%. Conclusion Our result showed that the isolating rate of IFG and the prevlence rate DM were high in this region, but the awareness, treatment and control rate in DM were low. It is essential to strengthen health promotion program on diabetic knowledge and to elevate the primary and secondary prevention in the rural of Heilongjiang,so as to raise the rate of control.
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65 years and 55~65 years respectively,whereas the frequency of IFG in each age group was close,which was more than IGT in the age group of 25~34 years only.The differences of many clinical indexs among 3 groups were significant.The change tendecny of indexs in IFG/IGT group was more obvious.Conclusion The onset characteristics of age and sex are significantly different between IFG and IGT groups,and the latter is more strongly associated with cardiovascular risk factors than the former.Undoubtedly,IFG/IGT group has the highest cardiovascular risk factors.