ABSTRACT
Se ratifica la importancia primordial de las determinantes sociales para explicar la salud, tanto de las poblaciones como de los individuos, pero especialmente en el caso de estos últimos, los factores biológicos no se pueden dejar de tener en cuenta, dada la heterogeneidad y singularidad de las personas. La susceptibilidad individual a padecer las enfermedades es bien conocida por los médicos que atienden pacientes desde antaño. Se plantea la necesidad actual de revalorar el peso de los factores biogenéticos en las determinantes de la salud de las personas, a la luz de los nuevos logros en el campo de la Biología y, concretamente en la genética, así como por la biotecnología, en el diagnóstico molecular. Se alerta que las nuevas técnicas que se van disponiendo deben implementarse de manera apropiada, acorde con la ética requerida y no deben inducir a que se abandone el método clínico, incluida la habilidad de recoger una buena historia clínica y una evaluación integral en cada paciente, las que siempre serán importantes para identificar las personas susceptibles que concurren a cualquier escenario asistencial(AU)
It is ratified the paramount importance of the social determinants to explain the health of the populations and of the individuals. Especially in the case of individuals, the biological factors must be taken into account, given the heterogeneity and singularity of the persons. Individual sensitivity to suffering some diseases is well-known for the doctors that have attended patients from a long time. It appears the current need to revaluate the influence of biogenetic factors in the health´s determinants of the persons, in the light of new achievements in the field of the Biology and more specifically in Genetics; as well as for the Biotechnology, in the molecular diagnosis. There is alerted that the new technologies that has been emerging must be implemented in an appropriate way, according to the needed ethics and they must not induce to abandon the clinical method, including the skills of collecting good clinical records and performing a comprehensive evaluation in every patient, which will be always important to identify sensitive persons who attend to any healthcare service(AU)
Subject(s)
Humans , Male , Female , Genetic Predisposition to Disease/genetics , Disease Susceptibility , Ethics , Precision Medicine , Social Determinants of HealthABSTRACT
Cancer is a general term of a series of complex traits of the disease triggered by the body cells losing their normal regulation of excessive proliferation, which essentially is a genetic disease.Recombinant inbred strain (RI) mouse generated from one pair of founders has been widely used in traditional tumor model.However, RI has many limitations on the statistic efficiency because of the small scale and lacking of allele diversity.The Collaborative Cross (CC) was designed to generate hundreds of recombinant inbred lines by 8 divergent strains of mice.CC mice embody a tremendous amount of natural genetic variation in different sub-strains of mouse and the single nucleotide polymorphism is four times of the traditional experimental mice.The high-genetic diversity and large scale population enables CC mice simulates the differences of individual susceptibility to the pathogeny or the therapies,thus provides a better research tool and information platform for expediting discovery of genes and genes function in human complex traits diseases.This review summarizes our current knowledge of this field, including methodologic aspects, applications, challenges and limitations, and utilization for cancer research.