ABSTRACT
Objetivo: Mapear o conhecimento acerca dos desfechos de sintomas gastrointestinais associados a Covid-19 na população pediátrica. Método: Trata-se de um protocolo de scoping review seguindo as recomendações do Instituto Joanna Briggs e do PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. A busca será realizada nas bases de dados Embase, Google Acadêmico, PubMed, Scopus, LILACS, CINAHL, Scielo, Web of Science e Portal da Biblioteca Virtual em Saúde. Serão utilizados os descritores criança, recém-nascido, trato gastrointestinal e Covid-19 e termos alternativos. Os resultados serão apresentados em formato de tabelas e analisados de forma descritiva. Conclusão: Esse protocolo norteará o desenvolvimento da revisão de escopo acerca do conhecimento sobre os achados clínicos e desfechos gastrointestinais na população pediátrica com diagnóstico de Covid-19.
Objective: To map the knowledge about the outcomes of gastrointestinal symptoms associated with Covid-19 in the pediatric population. Method: This is a scoping review protocol following the recommendations of the Joanna Briggs Institute and the PRISMA Extension for Scoping Reviews (PRISMA-scr): Checklist and Explanation. The search will be performed in the databases Embase, Google Scholar, PubMed, Scopus, LILACS, CINAHL, Scielo, Web of Science and Portal of the Virtual Health Library. The descriptors child, newborn, gastrointestinal tract and Covid-19 and alternative terms will be used. The results will be presented in table format and analyzed descriptively. Conclusion: This protocol will guide the development of a scope review on knowledge about clinical findings and gastrointestinal outcomes in the pediatric population diagnosed with Covid-19.
Objetivo: Mapear el conocimiento sobre los resultados de los síntomas gastrointestinales asociados a Covid-19 en la población pediátrica. Método: Se trata de un protocolo de revisión de alcance siguiendo las recomendaciones del Instituto Joanna Briggs y la Extensión PRISMA para Revisiones de Alcance (PRISMA-scr): Checklist and Explanation. La búsqueda se realizará en las bases de datos Embase, Google Scholar, PubMed, Scopus, LILACS, CINAHL, Scielo, Web of Science y Portal de la Biblioteca Virtual de Salud. Se utilizarán los descriptores child, newborn, gastrointestinal tract y Covid-19 y términos alternativos. Los resultados se presentarán en formato de tabla y se analizarán de forma descriptiva. Conclusiones: Este protocolo guiará el desarrollo de una revisión de alcance sobre el conocimiento de los hallazgos clínicos y los resultados gastrointestinales en la población pediátrica diagnosticada de Covid-19.
ABSTRACT
PURPOSE: We wanted to evaluate the clinical efficacy of an increased computed tomography attenuation coefficient (CTAC) of urine after the oral administration of iohexol in neonates who are suspected of suffering with neonatal necrotizing enterocolitis (NEC). MATERIALS AND METHODS: During a recent 1 year-period, seventeen neonates were admitted for suspected NEC, and they were divided into the suspected and definite groups based on their clinical signs and radiographic findings; we also included ten normal neonates as the control group. Diluted iohexol was administered and the CTACs of collected urine samples at 8-12 hour intervals were measured. Comparative analysis of the three groups was done and statistical significance was determined by the Scheffe test. RESULTS: Among 17 neonates, there were 13 neonates in the suspect group and 4 neonates in the definite group. The mean CTACs of urine in each group were 2711 HU (control group), 3411 HU (suspected group), and 7625 HU (definite group), respectively. There was a significant difference between the mean CTAC of the definite group and that of the control or suspected groups (Scheffe t >2.65). However, no statistically significant difference was seen between the suspected and control groups (Scheffe t=1.14). CONCLUSION: Although measurements of the CTAC of urine showed no significant diagnostic efficacy in the suspected group, the CTAC of urine, which reflects the correlated degree of bowel mucosal injury, can be a useful aid for determining the severity and progression of NEC.