ABSTRACT
Proinflammatory cytokines induced by peripheral immune challenge can activate the inflammatory reflex, which results in negative-feedback control of inflammation .Some recent studies revealed that it is the splanchnic nerve , not the vagus nerve , to constitute the efferent arm of the inflammatory reflex .Further researches are needed to iden-tify the neural construction and regulatory mechanism of the inflammatory reflex , which might be harnessed for the treatment of inflammation and the development of anti-inflammatory drugs .
ABSTRACT
The cholinergic anti-infla mmatory pathway regulates the inflammation response to injury,pathogens,tissue ischemia et al,by stimulating the peripheral vagus or centrally acting muscarinic agonists. It can regulate the systemic inflammation rapidly and directly,and inhibit the lethal effect of biotoxins (e.g,lipopolysaccharide). Based on the recent advancements,the historical origins and constitution of the cholinergic anti-inflammatory pathway,the connection between vagus and spleen,and the relationship with the inflammatory reflex are summarized.
ABSTRACT
The cholinergic anti-inflammatory pathway regulates the inflammation response to injury, pathogens, tissue ischemia et al, by stimulating the peripheral vagus or centrally acting muscarinic agonists. It can regulate the systemic inflammation rapidly and directly, and inhibit the lethal effect of biotoxins (e.g, lipopolysaccharide). Based on the recent advancements, the historical origins and constitution of the cholinergic anti-inflammatory pathway, the connection between vagus and spleen, and the relationship with the inflammatory reflex are summarized.