ABSTRACT
Objective To evaluate the clinical efficacy of endoscopic variceal ligation (EVL) combined with injection of tissue adhesive for esophageal and gastric varices bleeding.Methods Data of 452 patients with esophageal and gastric varices bleeding who received EVL and injection of tissue adhesive were retrospectively studied.Results The instant hemostatic rate was 100.0％ (145/145).Early rebleeding rate was 1.8％ (8/452).Incidence of early adverse reactions was 50.0％ (226/452).The total incidence rate of complications was 12.4％ (56/452).Efficiency and effectiveness of EVL were 32.5％ (145/446)and 40.4％(180/446) respectively.Efficiency and effectiveness of injection of tissue adhesive were 32.5％ (136/419) and 27.4％ (115/419) respectively.With an average of 18 months' follow-up (ranging from 9 to 37 months),the rate of rebleeding was 10.1％ (43/426),six-month and one-year survival rate was 97.9％ (417/426) and 89.9％ (383/426) respectively.Conclusion EVL combined with injection of tissue adhesive for esophageal and gastric varices is effective,convenient,and less invasive.They can be used not only for emergency hemostasis but also for secondary prophylaxis.