Inspiratory Muscle Strength in Chagas Cardiomyopathy: A Systematic Scoping Review

ABSTRACT The increase in inflammatory markers associated with persistent chronic fibrosing myocarditis, a characteristic of chronic Chagas disease, can result in a reduction in inspiratory muscle strength (IMS) in Chagas cardiomyopathy (CC). However, literature in this field is still scarce. This review aimed to map and summarize the evidence regarding IMS in patients with CC. The inclusion criteria included reports with adult participants with a CC diagnosis, with or without heart failure (HF). The core concept examined was the maximum inspiratory pressure evaluated in the untrained and trained groups in the pre-training period. The context was open, including but not limited to hospitals and health centers. Two authors independently identified eligible studies and extracted the data. Descriptive synthesis was used as the primary strategy for analyzing the results. Nine studies (five clinical trials, three cross-sectional, and one cohort) were included. The CC classification differed among the studies, with no mention of HF in five and no CC staging specification in six. IMS was assessed using a manovacuometer, and only six studies analyzed and interpreted the data concerning the predicted values. The CC population with HF appeared to have impaired IMS. All studies involved only Brazilian volunteers. In conclusion, randomized clinical trials evaluating IMS and the effects of inspiratory muscle training need to be conducted to better understand the prevalence and risk of inspiratory muscle weakness in the CC population, as well as the effects of training. Such studies should be conducted at different stages of CC in different populations and countries.

Comparação da força e resistência dos músculos inspiratórios entre ativos e sedentários / Comparison of the strength and resistance of inspirational muscles between assets and sedentary

Introdução: A prática regular de atividade física está associada com melhora do estado de saúde, aumento da capacidade funcional, aumento da força muscular e redução da mortalidade por doenças cardíacas. Apesar dos benefícios de a prática regular de exercício físico estarem consolidados na literatura, as adaptações na força e resistência dos músculos inspiratórios são controversas. Objetivo: Testar a hipótese que não há diferença da força e resistência dos músculos inspiratórios entre indivíduos ativos e sedentários. Métodos:Estudo observacional de corte transversal. Avaliou-se indivíduos entre 18 e 30 anos, ambos os sexos e saudáveis. Os voluntários foram divididos em ativos e sedentários de acordo a classificação da American College of Sports Medicine (ACMS). Os indivíduos tiveram a força máxima dos músculos inspiratórios (FMI) determinada através do dispositivo POWERbreathe® K5 inspiratory muscle trainer, que intula esta variável como Sindex. A resistência dos músculos inspiratórios foi avaliada través de um teste incremental. Para comparação das médias foi aplicada o teste t de student para distribuição simétrica, p< 0,05. O estudo foi aprovado pelo comitê de ética em pesquisa com CAAE : 37781014.4.0000.5544. Resultados: Foram avaliados 92 indivíduos, destes 55 (60%) foram classificados como ativos e 57 (62%) do sexo masculino. Ao realizar a comparação do Sindex entre ativos e sedentários (128±26; 119±24 cmH2O; p=0,85) e da exaustão no teste incremental (6516% e 6016%;p=0,095), respctivamente. Conclusão: Os indivíduos ativos não apresentam músculos inspiratórios mais fortes e resistentes quando comparados com sedentários. [AU]

Introduction: The regular practice of physical activity is associated with improved health status, increased functional capacity, increased muscle strength and reduced mortality from heart disease. Although the benefits of regular exercise are well established in the literature, adaptations in inspiratory muscle strength and endurance are controversial. Objective: To test the hypothesis that there is no difference in the strength and resistance of the inspiratory muscles between active and sedentary individuals. Methods: Cross-sectional observational study. It was evaluated individuals between 18 and 30 years old, both sexes and healthy. The volunteers were divided into active and sedentary according to the classification of the American College of Sports Medicine (ACMS). Individuals had maximal inspiratory muscle strength (IMS) determined through the POWERbreathe® K5 inspiratory muscle trainer, which injects this variable as Sindex. The inspiratory muscle strength was evaluated through an incremental test. For the comparison of the means the student's t-test was applied for symmetrical distribution, p <0.05. The study was approved by the research ethics committee with CAAE: 37781014.4.0000.5544. Results: A total of 92 individuals were evaluated. Of these, 55 (60%) were classified as active and 57 (62%) were male. When comparing Sindex between active and sedentary (128 ± 26/119 ± 24 cmH2O, p = 0.85) and exhaustion in the incremental test (63.2 ± 16.1%. p = 0.095), respectively. Conclusion: Active individuals do not present stronger and stronger inspiratory muscles when compared to sedentary ones. [AU]

The Outcomes of Short Term Inspiratory Muscle Training (IMT) Combined with Chest Physiotherapy in Hospitalized COPD Patients.

Objective: The objective of this study was to identify the outcomes of short term inspiratory muscle training (IMT) combined with chest physiotherapy (CP) on lung function, inspiratory muscle strength, exercise tolerance and quality of life of COPD patients. Materials and Methods: This randomized-controlled trial was conducted at the Terendak Armed Forces Hospital, Melaka. Eighteen hospitalized COPD patients (FEV1 50% to = 80% predicted) were randomized into intervention (IG) and control group (CG). The IG received IMT and CP treatments whilst the CG received only CP for a period of 4 weeks. Assessments of lung function (FEV1/FVC), inspiratory muscle strength (PImax), exercise tolerance (6MWT) and quality of life (SGRQ score) were taken at baseline and after 4 weeks. Results: Analysis showed IG group increased in FEV1/FVC by 19.4%, PImax by 54.7%, 6MWT by 33.2% and quality of life by 52.6% (All, p<0.05). The control group increased in FEV1/FVC by 8.7% (p>0.05), PImax by 15% (p<0.05), 6MWT by 18.9% (p<0.05) and quality of life by 15.6% (p<0.05). Conclusion: The present study has established that by combining inspiratory muscle training (IMT) and chest physiotherapy, provides superior effects on lung function, inspiratory muscle strength, exercise tolerance and quality of life among COPD patients.

Entrenamiento muscular inspiratorio en el paciente con enfermedad pulmonar obstructiva crónica / Inspiratory muscle training in patients with chronic obstructive pulmonary disease

Respiratory muscle weakness is observed in chronic obstructive pulmonary disease (COPD) patients and contributes to hypoxemia, hypercapnia, dyspnoea, nocturnal oxygen desaturation and reduced exercise performance. During exercise it has been shown that diaphragm work is increased in COPD and COPD patients use a larger proportion of the maximal inspiratory pressure (PImax) than healthy subjects. This pattern of breathing is closely related to the dyspnoea sensation during exercise and might potentially induce respiratory muscle fatigue. However, diaphragmatic fatigue was not demonstrated after exhaustive exercise. Studies in patients with COPD have shown natural adaptations of the diaphragm to greater oxidative capacity and resistance to fatigue. The above mentioned considerations gave conflicting arguments to the rationale of inspiratory muscle training (IMT) in COPD. Both IMT alone and IMT as adjunct to general exercise reconditioning significantly increased inspiratory muscle strength and endurance. A significant effect was found for dyspnoea at rest and during exercise. Improvedfunctional exercise capacity tended to be an additional effect of IMT alone and as an adjunct to general exercise reconditioning, but this trend did not reach statistical significance. No significant correlations were found for training effects with patient characteristics. However, subgroup analysis in IMTplus exercise training revealed that patients with inspiratory muscle weakness improved significantly more compared to patients without inspiratory muscle weakness. From this review it is concluded that inspiratory muscle training is an important addition to a pulmonary rehabilitation programme directed at chronic obstructive pulmonary disease patients with inspiratory muscle weakness. The effect on exercise performance is still to be determined. In summary, IMT improves inspiratory muscle strength and endurance, functional exercise capacity, dyspnoea and quality of life. Inspirat...

Los pacientes con enfermedad pulmonar obstructiva crónica (EPOC) tienen debilidad de los músculos respiratorios, lo cual contribuye a la disnea, hipoxemia, hipercapnia, desaturación nocturna y limitación de la actividad física. Durante el ejercicio se ha demostrado que aumenta el trabajo del diafragma en pacientes con EPOC y utilizan una mayor proporción de la presión inspiratoria máxima (PImax) comparado con los sujetos sanos. Elpatrón respiratorio anormal de los pacientes con EPOC está relacionado con la sensación de disnea durante el ejercicio y, potencialmente, podría inducir a la fatiga muscular respiratoria. Sin embargo, la fatiga del diafragma no se ha demostrado después de un ejercicio intenso. Los estudios en pacientes con EPOC han demostrado cambios adaptativos en las fibras musculares del diafragma que tienen mayor capacidad oxidativa y resistencia a la fatiga. De este modo, existen argumentos contradictorios en relación al beneficio clínico obtenido con el entrenamiento de los músculos inspiratorios (EMI) en pacientes con EPOC. El EMI aislado o como complemento de ejercicios de reacondicionamiento general aumenta significativamente la fuerza muscular inspiratoria y la resistencia a la fatiga, disminuyendo significativamente la disnea en reposo y durante el ejercicio. Además, los estudios sugieren que el EMI tiende a mejorar la capacidad funcional para realizar ejercicio, efecto favorable que no alcanzó significación estadística. El análisis de subgrupos ha demostrado mayor beneficio clínico del EMI en los pacientes con debilidad muscular inspiratoria. De esta revisión se concluye que el entrenamiento muscular inspiratorio puede ser útil en pacientes seleccionados con enfermedad pulmonar obstructiva crónica, que tienen disfunción muscular inspiratoria comprobada, insertado en un programa de rehabilitación integral. El efecto sobre la capacidad de realizar ejercicio aún no ha sido determinado. En resumen, el EMI aumenta la fuerza muscular inspirator...

Estudo das variações de pressão inspiratória máxima em tetraplégicos, tratados por meio de incentivador respiratório, em regime ambulatorial / Study of maximal inspiratory pressure variations in tetraplegics, treated by means of incentive spirometry, in outpatients

Introdução: O crescente número de vitimas de lesão medular nos tempos atuais, suas incapacidades e consequências físico-funcionais motivaram-nos a abordar no presente estudo a intervenção fisioterapêutica respiratória ambulatorial nesta população. Objetivos: Escolhemos pesquisar sujeitos com lesão adquirida traumática oriundos de uma associação na cidade de Curitiba, PR. Considerando-seque o prognóstico relaciona-se ao nível sensitivo e motor, selecionamos sujeitos com lesões cervicais,por se tratarem de quadros que estão acompanhados de disfunções respiratórias, estas decorrentes do acometimento dos músculos acessórios da respiração. Portanto, essa população é merecedora de uma abordagem preventiva, uma vez que as referidas disfunções podem produzir complicações e piora de prognóstico geral. Tivemos a preocupação de demonstrar as possíveis alterações da capacidade de força respiratória, em função da intervenção fisioterapêutica. Metodologia: Utilizamos, para tanto, o instrumento de medida, comparação e controle da força muscular inspiratória denominado manovacuometria.No tratamento, utilizamos o Threshold IMT, que é um incentivador respiratório. Para os critérios metodológicos, optamos por amostra conveniente, de corte longitudinal, em que foi realizada uma avaliação de força inspiratória inicial, objetivando-se alcançar os valores de pressão inspiratória máxima (PImáx), para comparar com a posterior reavaliação, pós intervenção. Os sujeitos foram submetidos a 30 atendimentos de 15 minutos cada, três vezes por semana. Após este período foram reavaliados sob os mesmos critérios técnicos, para as devidas comparações. Resultados: Os resultados permitiram constatar significativa melhora no condicionamento muscular respiratório, o qual atingiu o nível relevante do desvio padrão (p < 0,05). Conclusão: Concluímos, portanto, que a proposta de tratamento é eficaz.

Introduction: The growing number of victims of spinal cord injury, in modern times, with their disabilities and physical-functional consequences, motivated us to discuss in this study the respiratory physiotherapeutic intervention in outpatients. Objective: We choose to search individuals with traumatic injury acquired, from an association in the city of Curitiba, Paraná State. Considering that the prognosis is linked to the motor and sensory level, we selected persons with cervical lesions, by targeting frames that are accompanied by respiratory dysfunctions, those resulting from the involvement of accessories muscles of respiration. Therefore, this population deserves a preventive approach, because these dysfunctions can produce complications and reduced overall prognosis. We demonstrate the possible changes in respiratory force capacity, depending on the physiotherapeutic intervention. Methodology: We use, for that, the instrument of measurement, comparison and control of inspiratory muscle strength named manovacuometry. In treatment, we use the Threshold IMT, which is a respiratory supporter. For methodological criteria, we chose convenience sample, slitting, with an assessment of initial inspiratory force, aiming to achieve the values of maximal inspiratory pressure (MIP), to compare with subsequent reassessment after intervention. The subjects underwent 30 calls of 15 minutes each, three times a week. After this, they were re-evaluated under the same technical criteria for the appropriate comparisons. Results: Results show significant improvement in respiratory muscle conditioning, which reached the level of the relevant standard deviation (p < 0.05). Conclusion: We conclude, therefore, that the proposed treatment is effective.