ABSTRACT
[Summary] Metformin is the first‐line oral antidiabetic drug.However ,its antidiabetic mechanism is not well understood.The glucose‐lowering effect of Metformin has been attributed to increase insulin sensitivity and glucose disposal ,suppress hepatic gluconeogenesis and inhibit glucagon action.Metformin can decrease the glucose level by activating AMPK dependent/independent pathway ,but its antidiabetic effect is not limited to this.Here we reviewed antidiabetic mechanism of Metformin.
ABSTRACT
[Summary] Sodium glucose cotransporter 2 (SGLT2) inhibitors have been developed as a new antidiabetic agent .The antihyperglycemic effect of SGLT 2 inhibitors is independent of insulin secretion and insulin action .SGLT2 inhibitors improve IS and islet βcell function with the possible mechanisms of reducing glucotoxicity ,weight loss and increasing GLP‐1 response .