The Origin, Principles of Intense Pulsed Light and Its Proper Application in Clinical Practice / 대한피부과학회지

Intense pulsed light (IPL) is a high-intensity polychromatic incoherent light of a determined wavelength spectrum, fluence, and pulse duration. Clinicians can combine these variable factors of IPL for the purpose of selective destruction of target chromophores. Due to these properties, IPL has been widely used for numerous indications including hair removal and treatment of vascular or pigmented lesions. For skilled and experienced clinicians, IPL is a great treatment modality; however it can be a source of serious adverse effects when performed by untrained clinicians. Thus, to promote the proper and safe use of IPL, we summarized the origin, history, basic principles, and clinical application of IPL and discussed qualification factors needed for clinicians who use IPL.

Effect of multiple IPL treatment on cell senescence markers in skin fibroblasts / 中华医学美学美容杂志

Objective To study the effect of multiple IPL treatment on cell senescence markers of skin fibroblasts using UVA as a control and to make clear whether the multiple IPL treatment may result in cell senescence.Methods Cells were divided into three groups: one group without irradiation as a control,one group receiving IPL treatment with 15 J per cm2,and the last group receiving UVA irradiation with 9 J per cm2.IPL and UVA irradiation were performed once a day during five days.On the sixth day,the cells were collected.Senescence-associated β-galactosidase (SA-β-Gal) staining,cell cycle,reactive oxygen species (ROS) and telomere length were determined.Results Our results showed that five consecutive days of IPL irradiation had no effect on the activity of SA-β-Gal and telomere length and decreased the G1 ％ of cell cycle and the level of ROS in comparison with the control group (P＜0.05).On the contrary,five consecutive days of UVA irradiation increased the activity of SA β Gal and the level of ROS,shortened the length of telomere and no obvious change in the G1 ％ of cell cycle in comparison with the control group.Conclusions Multiple UVA irradiations induce cell senescence.On the contrary,multiple IPL treatments could not induce cell senescence.

Protective effect of intense pulsed light on fibroblast injury induced by UVA Ⅰ / 中华医学美学美容杂志

Objective To study the protective effects of intense pulse light (IPL) on the injury of normal human skin fibroblasts (FB) induced by ultraviolet A (UVA Ⅰ ) in vitro and to explore its possible mechanism. Methods The human skin fibroblasts were isolated and cultured, and then irradiated by UVA Ⅰ (9 J/cm2) and IPL (15 J/cm2), respectively. The proliferative ability of the cells were detected by CCK-8. Cell cycle was detected by flow cytometry, and cylin D1 and CDK2 protein expression levels were detected by Western blot. Results Different doses of UVA Ⅰ irradiation caused certain damages of cultured fibroblasts. With the increasing of of UVA Ⅰ dose, cell proliferation was decreased. Cells went to death at the exposure to 11 J/cm2 UVA Ⅰ , while the proliferative activity did not change much at 7 J/cm2 UVA Ⅰ . Cells were treated with UVA Ⅰ for other 2 days, then with IPL irradiation for other 2days, showing clear stimulating to the cell proliferation as compared with the cells that received UVA Ⅰ treatment only. Flow cytometry results showed that an increase of cell proliferating index, and cell cycle protein cyclin D1 and CDK2 expression levels were also upregulated after IPL irradiation.Conclusion UVA Ⅰ irradiation may cause cell damage as showed by cell growth index, cyclin D1 and CDK2 expression, and this injury could be protected partly by IPL treatment. The intense pulsed light may regulate the expression of cyclin proteins that may promote normal fibroblast proliferation, which could be one of the mechanisms of IPL skin rejuvenation.

The Principles of Intense Pulsed Light and Its Clinical Application / 대한피부과학회지

Intense pulsed light (IPL) is a high-intensity pulsed light source emitting polychromatic, non-coherent, and defocused light with a broad wavelength spectrum. However, IPL can similarly work as a conventional laser with the help of variable cut-off filters. It enables selective destruction of target chromophores based upon the theory of selective photothermolysis. Clinicians can combine variable factors including wavelengths, pulse durations, and fluences in IPL systems, which allow great versatility in treating wide ranges of dermatologic diseases and flexibility in optimizing individual treatment parameters according to different skin types or indications. These properties are of great advantage for skilled and experienced clinicians but can be a source of unwanted serious adverse effects for untrained ones at the same time. Therefore, we summarized the basic principles and clinical application of IPL devices to provide the practical guidance. In addition, critical diagnostics, a great deal of experience, and a thorough knowledge of skin pathology and physiology are required for an effective and safe IPL treatment.

The Effect of Intense Pulsed Light Treatment on the Vascular lesions / 대한피부과학회지

BACKGROUND: The intense pulsed light (IPL) system is a high-intensity pulsed light source which emits noncoherent, defocused, polychromatic light is a broad wavelength spectrum of 400-1200 nm. The mechanism of action of the light system corresponds to selective photothermolysis. Nowaday, the IPL system is widely used in the dermatologic field for the removal of unwanted hairs, epidermal melanocytic lesions, vascular lesions, and for photorejuvenation. OBJECTIVE: The purpose of this study was to evaluate the clinical results of diverse vascular lesions after treatment with an IPL source. METHOD: Forty Asian patients with vascular lesions were enlisted. The IPL treatment was administered to patients in 4-week sessions. Irradiation wavelength was controlled using cutoff filters ranging from 555 to 950 nm, with a fluence of 15-16J/cm2 (except forehead and zygomatic arch area), with single pulse illumination and a pulse width of 7 msec. RESULTS: At the end of the study, three physicians assessed the results and concluded that 72.5 % of the patients showed excellent or good results from the treatment. However, no difference was observed in 62.5 % of the patients after treatments. Furthermore, no specific adverse effects, except two cases of purpura and crust, were observed after the treatment. CONCLUSION: The treatment of vascular lesions on Asian skin using IPL is an effective, safe, and rapid treatment, with relatively few side effects and high patient satisfaction.

Three Cases of Facial Photorejuvenation by Intense Pulsed Light Quantum SR(TM) / 대한피부과학회지

Intense pulsed light (IPL) Quantum SR(TM) systems are high-intensity light sources, which emit polychromatic light. Unlike laser systems, these flashlamps work with noncoherent light in a broad wavelength spectrum of 560-1200 nm. IPL Quantum SR(TM) has been effective for the treatment of photoaging skin as a nonablative method. Three patients with photoaged skin were treated with fifth full-face treatments at 3-4 week intervals using IPL Quantum SR(TM). The cut-off filters of 560 nm and integrated contact cooling system were utilized for treatments. After the last treatments, the patients showed the overall improvement in clinical appearance, reduction in pigmentation and telangiectasia and fine wrinkle with smoothening of skin textures. Histological evaluations showed new collagen production after treatment. Full-face photorejuvenation using IPL Quantum SR(TM) can be an effective treatment modality for photoaged skin. We report herein IPL photorejuvenation is safe and effective in skin rejuvenation.

The Effect of Intense Pulsed Light Treatment on the Epidermal Melanocytic Lesions / 대한피부과학회지

BACKGROUND: Intense pulsed light(IPL) systems are high intensity pulsed sources which emit noncoherent, defocused, polychromatic light in a broad wavelength spectrum of 400-1200nm. The mechanism of action of such light systems corresponds to the selective photothermolysis.Nowdays, IPL system widely used in dermatologic field such as unwanted hair removal, epidermal melanocytic lesions, vascular lesions, and photorejuvenation OBJECTIVE: The purpose of this study was to evaluate the clinical results of diverse epidermal melanocytic lesions after treatment with an IPL source. METHOD: Twenty patients with epidermal melanocytic lesions were enlisted. IPL treatment was administered to the patients in a 4-week sessions. Irradiation wavelength was controlled using cutoff filters ranging from 400 to 700nm, with a fluence of 10-13.5J/cm2 with double pulse illumination and a pulse width of 7msec. RESULTS: By the end of the study, three attending physicians assessed the results for 85% of the subjects as excellent or good, with 85% of the patients reporting that same results; however, deep lesion such as Becker's nevus showed an average clearance of fair. No specific adverse effects except two case of blisters were observed after treatment. CONCLUSION: Treatment of epidermal melanocytic lesions in Asian skin using IPL is an effective, safe, and rapid treatment, with relatively few side effects and high patient satisfaction.