ABSTRACT
Objective To observe the long?term efficacy of neoadjuvant chemotherapy followed by intensity?modulated radiation therapy. Methods A retrospective analysis was performed on the data of 183 patients with locally advanced NPC who were hospitalized in our hospital:96 cases in the observation group, 87 cases in the con?trol group. Results There were no significant differences between the observation group and the control group in terms of five?year OS (77.1%vs. 78.2%, P=0.861), DMFS(89.6%vs. 90.8%, P=0.782), RFS (78.1%vs. 77%, P=0.857) and PFS (72.9%vs. 71.3%, P=0.803). Compared with the control group, the observation group did not sig?nificantly improve 5?year OS, DMFS, RFS and PFS in T3?4N0?1 patients and also did not improve 5?year OS, DMFS, RFS and PFS in T1?4N2?3 patients. There were significantly larger numbers of individuals with adverse reactions in the observation group than in the control group. Conclusions Compared with the long?term efficacy in the patients with locally advanced NPC between neoadjuvant chemotherapy followed by intensity?modulated radiation therapy with concurrent chemotherapy and intensity?modulated radiation therapy with concurrent chemotherapy, the progno?sis has no significantly differences and neoadjuvant chemotherapy followed by intensity?modulated radiation therapy with concurrent chemotherapy leads to a larger number of adverse reactions. The action of neoadjuvant chemothera?py followed by intensity?modulated radiation therapy with concurrent chemotherapy in treatment of locally advanced NPC needs more research.