ABSTRACT
Objective To explore the role of transemetil combined with various chemotherapy agents under the circumstance of continuous arterial infusion.Method MTT assays in cultured HepG2 and 7702 in vitro were used to detect the effects different sequences among different chemotherapy agents combined with transemetil.Results When combined with docetaxel,epirubicin,5-fluorouracil,pemetrexed disodium,cisplatin,or gemcitabine,transemetil had a synergistic effect.When combined with other agents,there was no synergistic or antagonistic effect.The synergistic effects were observed when transemetil acted during or after the use of chemotherapy agents.However,when chemotherapy agents were mixed with transemetil in advance,their effects decreased.Conclusion Transemetil showed an obvious synergistic effect when combined with certain chemotherapy agents.Different sequences between transemetil and chemotherapy agents showed different effects,and the mechanisms need further research to fully understand.
ABSTRACT
Objective Under the circumstance of continuous arterial infusion,role of magnesium isoglycyrrhizinate combined with different kinds of chemotherapy agents respectively were detected on the HepG-2 and 7702cell lines.Method MTT assay in cultured HepG-2 and 7702 in vitro were used to detect different chemotherapy agents combined with transemetil with different sequence; interaction of MgSO4 with chemotherapy agents were observed in HepG-2 cell lines.Results When combined with docetaxel,gemcitabine,epirubicin,5 fluorouracil,pemetrexed disodium,magnesium isoglycyrrhizinate had synergistic effect; when combined with other agents,there were no antagonism effect; 4 kinds of chemotherapy agents had slight synergistic effect with magnesium sulfate.Conclusion Magnesium isoglycyrrhizinate showed obvious synergistic effect when combined with chemotherapy agents; different sequence between magnesium isoglycyrrhizinate and chemotherapy agents showed different effect; the mechanism need more study.