ABSTRACT
Resumen Introducción: Investigaciones sobre el trastorno por déficit de atención e hiperactividad (TDAH) han evidenciado alteraciones en los procesos inhibitorios, en especial en el control de la interferencia, lo que explicaría las dificultades de los niños con TDAH para inhibir estímulos distractores y controlar su comportamiento. Objetivo: Identificar la literatura científica disponible sobre el desempeño en tareas que evalúan el control de la interferencia en niños con TDAH. Método: Se realizó una búsqueda de artículos científicos en las bases de datos de Pubmed, Scopus, Web of Sciencie con los términos ADHD (Attention Deficit Hyperactivity Disorder), Interference Control, Stroop y Flanker, publicados entre los años 2010 y 2017. Se identificaron 520 artículos, después de aplicar los criterios de inclusión y exclusión se seleccionaron 33 para hacer el análisis descriptivo. Resultados: El control de la interferencia se ve afectado en niños con TDAH, evidenciado en mayores tiempos de reacción, de ejecución, variabilidad de respuesta y porcentaje de errores, principalmente en los ensayos incongruentes. Igualmente, se mostraron patrones de activación cortical alterados y variaciones en potenciales evocados cognitivos. Conclusiones: El control de la interferencia se encuentra alterado en niños con TDAH, y el uso de más de un método de evaluación de los niños con este Trastorno puede ser útil para brindar más información del funcionamiento en el control de la interferencia en términos de tiempo y precisión en las tareas.
Abstract Introduction: Research on attention deficit hyperactivity disorder (ADHD) has shown alterations in interference control, which would explain the difficulties of children with ADHD to inhibit distracting stimuli and regulate their behavior. Objective: identifying available scientific literature about performance on task that evaluate the interference control in children with ADHD. Method: a search on Pubmed, Scopus and Web of Science databases with the terms ADHD, interference control, Stroop and Flanker, published between 2010 and 2017 was performed. 520 articles were identified, after applying the inclusion and exclusion criteria 33 articles were selected for descriptive analysis. Results: interference control is affected in children with ADHD, evidenced in greater reaction and execution times, variability of response and a high errors rate, primarily in incongruent trials. Altered cortical activation patterns and variations in cognitive evoked potentials were also shown. Conclusions: Interference control is altered in children with ADHD, the use of more than one evaluation method may be useful to provide more information on the functioning of interference control in terms of time and accuracy on tasks.
ABSTRACT
La evidencia empírica muestra que la inhibición es un proceso fuertemente implicado en el dominio y la adquisición de competencias sociales, emocionales y comportamentales. Sin embargo, a pesar del acuerdo respecto a su importancia en distintos ámbitos, aún existen divergencias en cuanto a su definición conceptual y operativa. Principalmente, existe un profundo debate en torno a si la inhibición es un constructo unitario o debería fragmentarse en un conjunto de procesos. El objetivo de este trabajo es describir los hallazgos y las posturas más significativas en relación con el estudio de dicho constructo, para lo cual, en primer lugar se hace una propuesta explicativa del control de la interferencia, basada en un enfoque no inhibitorio; en segundo lugar, se describen los modelos más representativos, de 1, 2 y 3 factores para, finalmente, enumerar algunos de los aportes y hallazgos planteados como principal fuente de evidencia a favor del enfoque fragmentado.
Empirical evidence shows that inhibition is a process strongly implicated in the dominion and acquisition of social, emotional and behavioral skills. However, despite the agreement on its importance in various areas, there is still divergence in terms of its conceptual and operational definition. Mainly, a deep debate exists whether inhibition is a unitary construct or must be fragmented into a set of processes. The objective of this study is to describe the findings and the most significant positions in relation to the study of this construct by first, making an explanatory proposal for interference control, based on a non-inhibitory approach; and secondly, describing the most representative 1, 2 and 3 factor models, to finally list some of the contributions and findings proposed as the main source of evidence for the fragmented approach.
A evidência empírica mostra que a inibição é um processo fortemente vinculado ao domínio e à aquisição de competências sociais, emocionais e comportamentais. Contudo, apesar da concordância a respeito de sua importância em diferentes âmbitos, ainda existem divergências quanto a sua definição conceitual e operativa. Principalmente, existe um profundo debate sobre se a inibição é um construto unitário ou deveria fragmentar-se num conjunto de processos. O objetivo deste trabalho é descrever os achados e os posicionamentos mais significativos no que se refere ao estudo desse construto; para isso, em primeiro lugar, faz-se uma proposta explicativa do controle da interferência, baseada num enfoque inibitório; em segundo lugar, descrevem-se os modelos mais representativos, de 1, 2 e 3 fatores para, finalmente, enumerar algumas das contribuições e constatações apresentadas como principal fonte de evidência a favor do enfoque fragmentado.
ABSTRACT
Objective To explore the response inhibition ability of oppositional defiant disorder symptoms children. Methods Subjects were 27 oppositional defiant disorder symptoms children and 27 normal children. They were asked to complete the stop signal task,go/no go task and the Simon task. Results The delay time of stop reaction (SOA,(260.27 ±69.12)ms) and go reaction time( (554.31 ±55. 81 )ms)of the oppositional defiant disorder symptoms children were shorter than the control group, the difference was significant (P＜0. 05). However,the stop reaction and interference control ability were no significant difference between these two groups. Conclusion Oppositional Defiant Disorder symptoms children's poor prepotent response inhibition ability is cognitive mechanism of their impulsive behaviors.
ABSTRACT
The codeinone reductase gene (cor) and the berberine bridge enzyme gene (bbe) were cloned from young leaf of opium poppy(Papaver somniferum L) by RT-PCR and the coding sequences of these gene were analyzed. The result demonstrated that the cloned COR gene sequence was highly homologous to the other COR gene family members showing 98.96% identity to COR1.1. The cloned BBE gene sequence was 94.84% identified with the released BBE genes in GenBank previously. Based on the cDNA sequences of COR and BBE,two fragments about 400～500 bp from each gene with lower identity among them were cloned. The fusion gene BC(744 bp) is fused by the PCR technique. Then the promoter CaMV 35S driven,containing'forward BC fusion fragments-reverse pdk intron-reverse BC fusion fragments',plant siRNA expression vector were constructed based on the vectors pHANNIBAL and pART27. Inhibition efficiency of the expression vector to the morphine synthesis was studied by transforming papaver nudicarule.The work will lay the foundation for breeding a low morphine and high thebaine poppy.