ABSTRACT
Colorectal cancer screening and monitoring are effective Methods to reduce the incidence and mortality of colorectal cancer. Endoscopic screening is indeed the most effective method at present. However, endoscopy is not perfect, and it may miss some precancerous lesions and colorectal cancer, or incomplete resection of some malignant lesions. Thereafter these lesions were diagnosed before the next endoscopic examination of cancer, that is interval Colorectal cancer. This article focuses on the latest findings on the etiology ,classification ,clinical molecular biology characteristics of I-CRCs，and also sums up the correct identification and monitoring of high-risk populations.
ABSTRACT
BACKGROUND/AIMS: Colonoscopic polypectomy is highly efficient in preventing colorectal cancer, but polyps may not always be completely removed. Improved knowledge of the risk factors for incomplete polyp resection after polypectomy may decrease the cancer risk and additional costs. The aim of this study was to investigate the conditions that can cause incomplete polyp resection (IPR) after colonoscopic polypectomy. METHODS: A total of 12,970 polyps that were removed by colonoscopic polypectomy were investigated. Among them, we identified 228 cases with a positive resection margin and 228 controls with a clear resection margin that were matched for age, gender, and polyp size. We investigated the location, morphology, and histological type of the polyps and evaluated the skills of the endoscopist and assisting nurse. RESULTS: Multivariate analysis revealed that the polyps, which were located in the proximal part of the colon and rectum, were at significant risk of IPR. Histologically, an advanced polyp and an inexperienced assistant were also independent risk factors for IPR. CONCLUSIONS: Polypectomy should be performed more carefully for polyps suspected to be cancerous and polyps located in the proximal part of the colon or rectum. A systematic training program for inexperienced assistants may be needed to decrease the risk of IPR.