Research advances in gene expressions and related signal transduction in the tight junction of intestinal epithelium / 中华临床营养杂志

The tight junction of intestinal epithelium plays an important role in maintaining the function of intestinal barrier and regulating the cell differentiation. The intestinal epithelial cells interact with neighboring cells and the extracellular matrix and then affect the epithelial barrier as well as the proliferation, polarization, and apoptosis of cells. As an important cell junction, the tight junction of intestinal epithelium participates in a series of signal transduction pathways including the classic cyclic adenosine monophosphate-protein kinase A-cyclic adenosine monophosphate response element-binding, inositol trisphosphate, Ras-mitogen-activated protein kinase, phosphatidylinositol 3-kinase, and in some special pathways including zonula occludents protein 1-associated Y-box factor,cyclin related protein, phosphorylation, and methylation. Furthermore, regulations of gene and protein expression of the tight junction are also complex, while disorders of such regulations may lead to clinical diseases, such as disruption of the intestinal barrier, refractory infection, and even cancers. This article reviews the research advances in gene expressions, related signal transduction, and self-regulation in the tight junction of intestinal epithelium.

Research progress of lactobacillus surface layer protein / 肠外与肠内营养

Lactobacillus can maintain the stability of microbiological environment in intestine and its surface layer protein controls the biological function of intestinal epithelia cells. The mechanism of adhering had been studied. In this article, we review the progress of surface layer protein in the study of the isolation, identification and the biological reaction with the intestinal epithelia cells .

The intestinal tight junction and the related diseases / 肠外与肠内营养

Tight junctions(TJ) are the primary junctions between intestinal epithelia.TJ serves as the maintenance of epithelial cell polarity and the rate-limiting barrier to passive movement of hydrophilic solutes across intestinal epithelia.The disrupture of TJ may cause or promote some diseases.This review is about structure,biological functions,molecular regulating mechanisms of intestinal epithelial tight junctions and some related diseases.