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Objective:To discuss the effect of remnant cholesterol (RC) levels on carotid intima thickness (CIT) in patients with type 2 diabetes mellitus (T2DM) by ultra-high frequency ultrasound.Methods:A total of 60 patients with T2DM who received treatment in Henan Provincial People′s Hospital from May 2021 to July 2022 were prospectively recruited, and they were divided into a higher RC group (31 cases) and a lower RC group (29 cases) according to the RC levels. Thirty-one age, sex and body mass index(BMI)-matched healthy volunteers were selected as control group. Carotid CIT, carotid media thickness(CMT) and intima-media thickness(CIMT) were measured by 24 MHz ultra-high frequency ultrasound probe. The difference of general clinical data, laboratory indicators and CIMT, CIT, CMT among the three groups were compared, and the influencing factors of CIT in T2DM patients were explored by multivariate regression analysis.Results:①There were no statistical significances in gender, age, BMI, high-density lipoprotein cholesterol (HDL-C) and CMT among the three groups (all P>0.05). There were no statistical significances in duration of diabetes, fasting blood-glucose and glycated haemoglobin between the two subgroups of T2DM (all P>0.05). ②Compared with the control group, CIMT and CIT were thicker in the T2DM group (both P<0.05). ③CIT was thicker in the higher RC group than in the lower RC group ( P<0.05), while the difference of CIMT was not statistically significant the two groups ( P>0.05). ④Multivariate regression analysis showed that RC was the influence factor of CIT in patients with T2DM(β=0.610, P=0.005). Conclusions:CIT is significantly thicker in T2DM patients with higher RC than in those with lower RC, and RC is the influence factor of CIT, which suggests that more attention should be paid to the detection of RC in T2DM patients.
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Objectives: To investigate the relationship between helicobacter pylori (Hp) infection and carotid intima thickness. Methods: We searched the databases of Pubmed, Embase, CNKI, VIP and Wanfang for published studies on the relationship between Hp infection and carotid intima thickness in China and abroad. 2 reviewers independently identified and enrolled the articles, extracted specific data and assessed the quality of reference by Jadad scale. Meta-analysis was conducted by Stata 12.0 Software. Results: A total of 9 case-control studies were enrolled, all the reference quality scores≥4 which included 694 subjects with Hp positive and 676 with Hp negative. Meta-analysis indicated that carotid intima thickness was higher in Hp positive subjects than Hp negative subjects, standard mean difference (SMD)=0.803, 95% CI(0.686-0.919), P<0.05. Age related study presented that carotid intima thickness was higher in Hp positive subjects than Hp negative subjects at the age≥60 years'population, SMD=1.296, 95%CI (1.125-1.467), P<0.05; carotid intima thickness was also higher in Hp positive subjects than Hp negative subjects at the age<60 years'population, SMD=0.379, 95%CI (0.220-0.537), P<0.05. Conclusions: Hp infection has been related to the thickness of carotid intima and it could make carotid artery intima thickening.
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INTRODUCCIÓN: El score de calcio coronario y la cuantificación del grosor de íntima media son métodos en desarrollo que se utilizan en el diagnóstico de aterosclerosis. OBJETIVO: Evaluar la relación del puntaje de calcio coronario con los factores de riesgo cardiovasculares clásicos y el grosor de la íntima media carotídea. MÉTODOS: Se tomaron 70 pacientes con sospecha de cardiopatía isquémica. A todos se les cuantificó el calcio coronario por tomografía de 64 cortes y el grosor de íntima media en carótidas por ultrasonido. Usando la variable dependiente (score de calcio coronario) de forma continua, fue realizada una regresión lineal simple para obtener los coeficientes de regresión (a). El nivel de significación estadística (a) con que se trabajó fue del 95 por ciento (valor p < 0,05 como estadísticamente significativo). RESULTADOS: El puntaje de calcio fue superior en individuos del sexo masculino y se incrementó de manera lineal con el decursar de las décadas de edad, por cada año que se incrementa la edad, aumenta en 11,4 UA el score de calcio. El coeficiente de correlación entre el score de calcio y la edad fue de 0,36 estadísticamente significativo (p= 0,002). El 88,9 por ciento de los pacientes con grosor íntima media mayor de 1 mm tenían algún grado de calcificación coronaria, fue 2 veces mayor que los que presentaron un grosor de íntima media menor que 1 mm. El valor de la correlación (r) con el grosor de la íntima media carotídea fue de 0,24 (p= 0,04). CONCLUSIONES: La edad, el sexo masculino y el aumento del grosor íntima media carotídea se relacionan de manera significativa con la presencia y cuantía de la calcificación coronaria
INTRODUCTION: The coronary calcium's score and the quantification of media intima thickness are developing methods used in atherosclerosis diagnosis. OBJECTIVE: To assess the coronary calcium score relation to classic cardiovascular risk factors and the carotid media intima thickness. METHODS: Sample included 70 patients with suspicion of ischemic heart disease. In all of them the coronary calcium was quantified by 64 scans tomography and the media intima thickness by medias of ultrasound (US). Using continuously the dependent variable (coronary calcium score) we made a simple linear regression to obtain the regression coefficients (a). The statistic significance level (a) used was of 95 percent (value p < 0,05 as statistically significant). RESULTS: Calcium score was higher in male sex subjects increasing linearly and annually with age in 11.4 UA. The correlation coefficient between calcium score and age was of 0.36 statistically significant (p = 0,002). The 88,9 percent of patients with a media intima thickness greater than 1mm had some degree of coronary calcification, was twice greater than those with a media intima thickness less than 1mm. Correlation value (r) with carotid media intima thickness was of 0.24 (p = 0.04). CONCLUSIONS: Age, male sex and increase of carotid media intima thickness, is significantly related to presence and quantity of coronary calcification
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Early detection of risk factors related with atherosclerosis, is necessary to decrease the morbidity and mortality of cardiovasular disease(CVD). Carotid intima-media thickness (IMT) is regarded as a surrogate markers of cardiovascular risk, believed to detect high risk better than traditional risk factors alone have been proposed. There were numerous studies which were evaluated the correlation with carotid IMT and cardiovascular events. In addition, measure of carotid IMT is safe, noninvasive, and relatively inexpensive method to detect early changes of atherosclerosis. Recently, the method which could measure carotid intima and media thickness seperatly, was developed . In this issue, Won et al, reported that in hypertensive patients, media thickness was greater than that of normotensive patients. however, intima thickness was not different in between two groups. They concluded medial hypertrophy contribute to increase IMT in hypertensive patients. However, there are technical limitation related with the characteristics of ultrasound., individual measurement of intima and media is very promising method to evaluate the disease progression earlier than the other methods. Thus this method can be applied to identify and track the progression of atherosclerotic disease.
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Humans , Atherosclerosis , Biomarkers , Carotid Intima-Media Thickness , Disease Progression , Hypertension , Hypertrophy , Risk Factors , Track and FieldABSTRACT
The severity of carotid intima-media thickness (IMT) is an independent predictor of atherosclerosis which causes transient cerebral ischemia, stroke, and coronary events such as myocardial infarction. The IMT consists of intima thickness (IT) and media thickness (MT). However, the Individual clinical significance of IT and MT has not been well studied. We devised a method of measuring IT, MT, and IMT using B-mode ultrasound image processing technique for the diagnosis of atherosclerosis. To inspect the clinical significance of IT, MT, and IMT, one hundred forty-four consecutive patients (mean age; 57 years old, 72 males) were underwent common carotid artery scanning using high-resolution ultrasound. Results showed that, the IT (p<0.05), MT (p<0.05) as well as IMT (p<0.01) of patients with atherosclerotic disease were significantly thicker than that of the patients without atherosclerotic disease. Patients with hypertension showed significantly thicker IT (p<0.01), MT (p<0.001), and IMT (p<0.001). However, only IT was thicker in patients with smoking (p<0.01). The IT (r=0.374, p=0.001), MT (r=0.433, p=0.000), and IMT (r=0.479, p=0.000) showed positive correlation with age. The coefficients of determination (r(2)) were estimated to be 92.4% for IMT and MT, 49.1% for IMT and IT, and 27.4% for IT and MT. This result suggests that the intima layer of the carotid artery has a different physiology with the media layer.