ABSTRACT
We describe a case of metastatic alveolar soft part sarcoma of the brain in a 31 year old women. Alveolar soft part sarcoma is rare tumor that occurs mostly in the extremities and have a high incidence of blood born metastasis. Cerebral metastasis may be the first manifestation of the disease. The histogenesis of alveolar soft part sarcoma remains uncertain. The primary therapeutic option is aggressive surgical excision. Survival even with the development of metasrasis can be long.
Subject(s)
Adult , Female , Humans , Brain , Extremities , Incidence , Neoplasm Metastasis , Sarcoma, Alveolar Soft PartABSTRACT
We describe a case metastatic alveolar soft part sarcoma of the brain in a 20-year old man. Alveolar soft part sarcoma is slowly growing tumor which almost shows conspicuous vascular invasion and have a high incidence of blood-borne metastasis. The principal metastatic sites are the lungs, followed by the skeleton and brain. Cerebral metastases may be the first manifestation of the disease and are more common with alveolar soft part sarcoma than with any other type of soft tissue sarcoma. The light-and electron-microscopic and immunohistochemical findings are described. Periodic acid-Schiff-positive, diastase resistant, intracytoplasmic crystals, pathognomonic for alveolar soft part sarcoma, are present. The cells expressed immunoreactivity for vimentin, desmin, neuron-specific enolase, S-100 protein and renin. The results of our own immunohistochemical examinations is suggestive of myoendocrine origin.