ABSTRACT
ABSTRACT: This study described the pathological aspects of a mature intracranial teratoma with meningocele in a one-day-old lamb. The diagnosis of mature teratoma was based on microscopic features, where well-differentiated tissues representative of the three germ layers were observed. The tumor consisted of respiratory, gastrointestinal and urinary epithelium as components of the endoderm; muscle and bone tissues as components of the mesoderm; and keratinized stratified squamous epithelium and adnexa as components of the ectoderm. To the best of our knowledge, this is the first report of intracranial teratoma with meningocele in animals.
RESUMO: Descrevem-se os aspectos patológicos de um teratoma intracraniano benigno com meningocele em um cordeiro de um dia de idade. O diagnóstico de teratoma benigno foi baseado nos achados histopatológicos, com tecidos representativos das três camadas germinativas. O tumor consistia de epitélio respiratório, gastrintestinal e urinário como componentes do endoderma; tecido muscular e ósseo do mesoderma; e epitélio escamoso estratificado queratinizado e anexos como componentes do ectoderma. Com base no conhecimento dos autores, este é o primeiro relato de teratoma intracraniano com meningocele em animais.
ABSTRACT
Congenital intracranial teratoma is rare and it's prognosis is very poor with death usually occurring after birth. Moreover it is very rare for intracranial teratoma to be diagnosed in utero. Recently, we experienced a case of fetal intracranial teratoma at 26 weeks of gestation, which is placed in the middle area of cranial cavity. On the monitor of ultrasonogram, the mass was seen as a hyperechogenic mass and its size was 20~30 mm in diameter and it was located in the region of thalamus. The finding of microscopic examination was that neuroepithelial and neuroglial nests and primitive epithelial cells were aggregated and this finding was consistent with immature teratoma. We report a case with a brief review of the literature.
Subject(s)
Pregnancy , Epithelial Cells , Parturition , Prenatal Diagnosis , Prognosis , Teratoma , Thalamus , UltrasonographyABSTRACT
Congenital intracranial teratoma is a very rare tumor. We recently experienced a case of massive congenital intracranial teratoma that discovered in a male infant of 28 weeks of gestation. A 33-year old multigravida was observed at 28 weeks gestation for prenatal ultrasound examination and ultrasonography revealed the fetus was severely macrocephalic with marked hydrocephalus. For therapeutic termination, Hysterotomy and fetal cephalocentesis was performed to deliver a stillborn infant. Autopsy revealed a 2,420 g male infant with severe macrocephaly. A multilobulated intracerebral tumor was found a diameter 18 cm involving both cerebral hemisphere. The tumor was considered to have originated in the vicinity of pineal gland and suprasellar region. Microscopic examination showed the characteristic picture of a teratoma. The predominent component is immature neuroepithelium in the form of primitive neural tubules variably mature somatic tissure from other germ cell layers accompany the neuroepithelium. We report a case of congenital intracranial immature teratoma.
Subject(s)
Adult , Humans , Infant , Male , Pregnancy , Autopsy , Cerebrum , Fetus , Germ Cells , Hydrocephalus , Hysterotomy , Megalencephaly , Pineal Gland , Teratoma , UltrasonographyABSTRACT
Massive congenital intracranial teratoma (MCIT) is a very rare tumor and only one case has been reported in Korea. We report a case of MCIT discovered in a male infant of 25 weeks of gestational age. Prenatal ultrasound revealed a large heterogenous echoic mass which almost replaced the intracranial content. The infant was severely macrocephalic with a small but normal appearing body. The cranial vault was almost entirely occupied by an 18cm sized, multilobulated, partially cystic mass that displaced the severely distorted and attenuated cerebral cortex. Microscopically, the bulk of the tumor was composed of embryonal neuroepithelium with mature glial tissue and choroid plexus. Cartilage, liver, mature squamous epithelium and differentiated mesenchymal elements such as muscle and adipose tissue were found within the tumor.